Rebecca Usadi
A5086164230- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Sperm and Testicular Function
- Gynecological conditions and treatments
- Uterine Myomas and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Reproductive Health and Contraception
- Ovarian cancer diagnosis and treatment
- Genetic and phenotypic traits in livestock
- Maternal and fetal healthcare
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- Connective tissue disorders research
- Estrogen and related hormone effects
- Pregnancy and Medication Impact
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Reproductive Physiology in Livestock
- Health and Medical Research Impacts
- Meta-analysis and systematic reviews
- Intraperitoneal and Appendiceal Malignancies
Carolinas Medical Center
2013-2024
Atrium Medical Cente
2020-2023
Prisma Health
2005-2022
University of South Carolina
2022
Northwestern University
2022
Augusta University
2014-2022
Wayne State University
2022
University of Oklahoma Health Sciences Center
2022
University of Illinois Chicago
2022
Colorado School of Public Health
2022
Clomiphene is the current first-line infertility treatment in women with polycystic ovary syndrome, but aromatase inhibitors, including letrozole, might result better pregnancy outcomes.
Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of unknown aetiology characterized by hyperandrogenism, chronic anovulation and defects in glucose homeostasis. Increased luteinizing hormone relative to follicle-stimulating secretion, insulin resistance developmental exposure androgens are hypothesized play causal role PCOS. Here we map common genetic susceptibility loci European ancestry women for the National Institutes Health PCOS phenotype, which confers...
The standard therapy for women with unexplained infertility is gonadotropin or clomiphene citrate. Ovarian stimulation letrozole has been proposed to reduce multiple gestations while maintaining live birth rates.We enrolled couples in a multicenter, randomized trial. Ovulatory 18 40 years of age at least one patent fallopian tube were randomly assigned ovarian (up four cycles) (301 women), (300), (299). primary outcome was the rate among clinical pregnancies.After treatment gonadotropin,...
Women with obesity and infertility are counseled to lose weight prior conception treatment improve pregnancy rates birth outcomes, although confirmatory evidence from randomized trials is lacking. We assessed whether a preconception intensive lifestyle intervention acute loss superior neutral at achieving healthy live birth.In this open-label, controlled study (FIT-PLESE), 379 women (BMI ≥ 30 kg/m2) unexplained were randomly assigned in 1:1 ratio 2 modification groups lasting 16 weeks,...
In overweight/obese women with polycystic ovary syndrome (PCOS), the relative benefit of delaying infertility treatment to lose weight vs seeking immediate is unknown.We compared results two, multicenter, concurrent clinical trials treating in PCOS.This was a secondary analysis two randomized conducted at academic health centers studying 18-40 years age who were and infertile PCOS.We clomiphene from Pregnancy Polycystic Ovary Syndrome II (PPCOS II) trial (N = 187) delayed after preconception...
To determine if maternal major depression (MD), antidepressant use, or paternal MD are associated with pregnancy outcomes after non-IVF fertility treatments.Cohort study.Clinics.Participants in two randomized trials: PPCOS II (clomiphene citrate versus letrozole for polycystic ovary syndrome), and AMIGOS (gonadotropins clomiphene unexplained infertility).Female male partners completed the Patient Health Questionnaire (PHQ-9). Female medication use was collected. PHQ-9 score ≥10 used to...
Context: It is generally assumed that delayed endometrial development observed in luteal phase deficiency (LPD) the result of abnormally low progesterone (P) levels. This hypothesis has never been tested by direct experiment.
In Brief OBJECTIVE: To determine how often women with Ehlers-Danlos syndrome experience obstetric and gynecologic issues both compared the general population within three most common subtypes of syndrome. METHODS: An anonymous, prospective, online questionnaire in English was posted to National Foundation web site (http://ednf.org). RESULTS: Of 1,769 those who completed survey, 1,225 reported a typed diagnosis Further stratification types reproductive-aged (n=775) allowed conclusions be made...
To identify baseline characteristics of women with unexplained infertility to determine whether treatment an aromatase inhibitor will result in a lower rate multiple gestations than current standard ovulation induction medications.Randomized, prospective clinical trial.Multicenter university-based practices.A total 900 couples infertility.Collection demographics, blood samples, and ultrasonographic assessments.Demographic, laboratory, imaging, survey characteristics.Demographic receiving...
Among infertile women undergoing ovarian stimulation, is allostatic load (AL), a measure of chronic physiological stress, associated with subsequent fertility and pregnancy outcomes? AL at baseline was not conception, spontaneous abortion or live birth, however, it significantly increased odds pre-eclampsia preterm birth among who had in the study. Several studies have linked during to adverse outcomes including pre-eclampsia, hypothesizing that may contribute well-documented disparities...
Objective. To determine if sexual intercourse reduces absorption of vaginal progesterone gel in women and to is absorbed by the male during intercourse. Study Design. Prospective, randomized, cross over, controlled study 20 reproductive-aged their partners randomized receive (Crinone 8% gel, Actavis Inc., USA) or placebo cream. Serum for both female were measured 10 hours after One week later, subjects crossed over opposite formulation. In third week, used at night abstained from Results....
The most common cause of female infertility is polycystic ovary syndrome (PCOS), which occurs in 5% to 10% reproductive-age women. Clomiphene citrate has been used as a fertility agent for decades and the current first-line treatment women with PCOS. However, this selective estrogen-receptor modulator number drawbacks. In addition its overall poor efficacy, clomiphene associated high multiple-pregnancy rate compared unassisted conception an undesirable adverse effect profile, including...
Women with polycystic ovary syndrome (PCOS) have increased risk for pregnancy complications, possibly related to pre-existing obesity and excessive gestational weight gain (GWG). To assess the contributions of diagnosis preconception on GWG perinatal outcomes. Prospective cohort study singleton pregnancies in PCOS (n = 164) ovulatory controls 176) from infertility treatment. GWG, birthweight, complications. From baseline, normal-weight women gained 2.3 pounds more during first trimester (95%...
<h3>Importance</h3> Women with an early nonviable pregnancy of unknown location are at high risk ectopic and its inherent morbidity mortality. Successful timely resolution the gestation, while minimizing unscheduled interventions, important priorities. <h3>Objective</h3> To determine if active management is more effective in achieving than expectant whether use empirical methotrexate noninferior to uterine evacuation followed by needed. <h3>Design, Setting, Participants</h3> This multicenter...