A5011775419- Thyroid Disorders and Treatments
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Thyroid Cancer Diagnosis and Treatment
- Air Quality and Health Impacts
- Gestational Diabetes Research and Management
- Global Health Care Issues
- Climate Change and Health Impacts
- Neonatal Health and Biochemistry
- Maternal and fetal healthcare
- Pregnancy and Medication Impact
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Breastfeeding Practices and Influences
- Cancer Risks and Factors
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Development and Preterm Care
- Bariatric Surgery and Outcomes
- Gestational Trophoblastic Disease Studies
- Vitamin D Research Studies
- Cardiovascular Issues in Pregnancy
- Child and Adolescent Psychosocial and Emotional Development
- Assisted Reproductive Technology and Twin Pregnancy
- Growth Hormone and Insulin-like Growth Factors
- SARS-CoV-2 detection and testing
NordLab
2015-2024
University of Oulu
2015-2024
Oulu University Hospital
2015-2024
Karolinska Institutet
2021-2022
Division of Cancer Epidemiology and Genetics
2022
National Cancer Institute
2022
National Institutes of Health
2012-2021
Finnish Institute for Health and Welfare
2010-2020
Erasmus MC
2020
Sir Charles Gairdner Hospital
2020
Preeclampsia, a new-onset hypertensive disorder of pregnancy, is associated with lifetime cardiovascular disease risk, but less known about risk after other pregnancy-related hypertension.The Northern Finland Birth Cohort 1966 included all expected births from 1 year (N=12 055 women). Blood pressure measurements and prospective data were determined prenatal care records questionnaires for 10 314 women. Subsequent diagnoses ascertained Finnish registries (average follow-up, 39.4 years)....
There are only a few large prospective studies involving evaluation of the effect maternal thyroid dysfunction on offspring and observations inconsistent.The objective study was to investigate effects or antibody positivity perinatal outcome.The included population-based Northern Finland Birth Cohort 1986 including 9247 singleton pregnancies. First-trimester serum samples were analyzed for hormones [TSH, free T(4) (fT4)] antibodies [thyroid-peroxidase (TPO-Ab) thyroglobulin (TG-Ab)]. Mothers...
Thyroid diseases are inconsistently reported to increase risk for pregnancy complications. The objective of this study was complications associated with common and uncommon thyroid diseases. We analyzed singleton pregnancies (N = 223 512) from a retrospective US cohort, the Consortium on Safe Labor (2002–2008). outcomes were derived electronic medical records. Multivariable logistic regression generalized estimating equations estimated adjusted odds ratios (ORs) 99% confidence intervals (99%...
Knowledge is scarce concerning the significance of thyroid dysfunction/antibodies during pregnancy in regard to complications/later maternal morbidity.The aim this study was evaluate association between and complications or later hypertension, diabetes, disease.We studied a prospective population-based cohort, Northern Finland Birth Cohort 1986 (NFBC 1986), with follow-up 20 yr. Medication hospital discharge records were used assess morbidity diseases.The consisted mothers NFBC early serum...
Thyroid dysfunction and antibodies are increasingly recognized as risk factors during pregnancy. function changes pregnancy there is a need for gestational age-specific reference intervals thyroid hormones. The aim of this study was to calculate thyrotropin (TSH), free thyroxine (fT4), triiodothyronine (fT3) in an iodine-sufficient antibody-negative population.The population consisted large, prospective population-based cohort, the Northern Finland Birth Cohort 1986 (singleton births, n =...
Context:Maternal hypothyroidism during pregnancy is associated with adverse neuropsychological development in the offspring.
Maternal hypothyroidism has previously been shown to increase risk for neonatal intensive care treatment, but otherwise the association between thyroid diseases and morbidity is understudied. The Consortium on Safe Labor, a retrospective cohort (2002–2008), included 223,512 singleton deliveries of which 0.2% had hyperthyroidism, 1.4% primary 0.1% iatrogenic hypothyroidism, 1.3% other/unspecified disease. Logistic regression with generalized estimating equations estimated adjusted odds ratios...
Copeptin, a surrogate biomarker of vasopressin, has been associated with renal function decline and may serve as useful early for preeclampsia. We measured serum copeptin using samples collected longitudinally during pregnancy among unaffected controls (n=136) cases preeclampsia (n=169), gestational diabetes mellitus (n=92), hypertension (n=101), preterm birth (n=86) in the Calcium Preeclampsia Prevention trial (1992-1995). were defined having diastolic blood pressure≥90 mm Hg on 2 occasions...
Background: Maternal hypothyroidism has been associated with adverse pregnancy outcomes. A large nationwide register-based cohort data on medication purchases was established to study the associations between maternal hypothyroidism, levothyroxine (LT4) use, and perinatal complications. Methods: The included all singleton births 2004 2013 (N = 571,785) in Finland. Hypothyroid mothers (n 16,364) were identified Finnish Medical Birth Register. Of these women, 95.8% used LT4 medication, 37.5%...
Preeclampsia is characterized by alterations in angiogenic factors that may increase neonatal morbidity independent of preterm birth.We estimated the controlled direct effect preeclampsia on outcomes birth among 200,103 normotensive and 10,507 preeclamptic singleton pregnancies Consortium Safe Labor (2002-2008). Marginal structural models with stabilized inverse probability weights accounted for potential confounders pathway from to outcomes, including mediator-outcome related status, such...
Maternal hypothyroidism and/or hypothyroxinemia have been associated with child's poor neuropsychological development, but the results inconsistent.The Northern Finland Birth Cohort 1986 included all expected births within a year (9362 women, 9479 children) from two northernmost provinces of Finland. serum samples (n = 5791) were obtained in early pregnancy (M ± SD 10.7 2.8 weeks' gestation), and their children at 16 years age 5829). All analyzed for thyrotropin, free thyroxine (fT4),...