Long noncoding RNAs (lncRNAs), once considered to be nonfunctional relics of evolution, are emerging as essential genes in tumor progression. However, the function and underlying mechanisms lncRNAs glioma remain unclear. This study aimed investigate role LINC00998 Through screening using TCGA database, we found that was downregulated glioblastoma tissues low expression associated with poor prognosis. Overexpression inhibited cell proliferation vitro vivo blocked G1/S cycle transition, which...

The prognosis of human astrocytoma is poor, and the molecular alterations underlying its pathogenesis still needed to be elucidated. Nucleolar spindle associated protein 1 (NUSAP1) was observed in several types cancers, but role remained unknown. expression NUSAP1 cell lines tissues were measured with western blotting Real-Time PCR. Two hundred twenty-one tissue samples analyzed by immunochemistry demonstrate correlation between clinicopathological characteristics....

Background: The progression and metastasis of cancers are associated with systematic immune inflammation nutritional dysfunction. systemic immune-inflammation index prognostic (PNI) have shown a impact in several malignancies. Therefore, our study aimed to evaluate significance patients medulloblastoma (MB). Methods: We retrospectively analyzed 111 MB between 2001 2021 at institution. optimal cutoff values for (SII), neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte counts ration (MLR),...

Labeling and imaging of live cells with quantum dots (QDs) has attracted great attention in the biomedical field over past two decades. Maintenance fluorescence QDs a biological environment is crucial for performing long-term cell tracking to investigate proliferation functional evolution cells. The cell-penetrating peptide transactivator transcription (TAT) well-studied efficiently enhance transmembrane delivery. Here, we used TAT peptide-conjugated (TAT–QDs) as model system examine...

The purpose of this study was to explore the diagnostic significance abdominal sonography (AUS) in infants with Necrotizing enterocolitis (NEC) admitted a neonatal intensive care unit better evaluate ability AUS differentiate necrotizing from other intestinal diseases.All patients diagnosed NEC at Department General Surgery and Neonatal Surgery, Qilu Children's Hospital between 1st, Jun, 2010 30th, Dec, 2015. logistic regression analysis area under receiver operating characteristic (ROC)...

Wilms' tumor (WT) is the most common malignant renal in children. Previous studies suggested reversion-inducing, cysteine-rich protein with Kazal motifs (RECK) down-regulation might have a role numerous human cancers. The current study was done to investigate associations of RECK single-nucleotide polymorphisms (SNPs) WT susceptibility Chinese children.We analyzed 2 SNPs (rs10972727 and rs11788747) total 97 children 194 healthy matched controls (1:2 ratio) by real-time PCR PCR-RFLP...

This study aimed to compare the functional outcomes of Y-type locking plate with straight reconstruction for severe displaced scapular fractures.This was a retrospective cohort 37 patients body and neck fractures treated between July 2013 October 2016 at Hanzhong Central Hospital. Treatment selection based on surgeon's experience discussion patient. Sixteen received plates 21 plates. The primary indexes were Constant Shoulder Function (CSF) Disabilities arm, shoulder, hand (DASH) scores 3,...

Background: Medulloblastoma is the most common pediatric malignant tumor in central nervous system. Although its prognosis has been improved enormously by combination treatments with surgery, radiotherapy, and chemotherapy, it still could progress via invasion distant dissemination. We aimed to investigate molecular mechanisms of medulloblastoma current work. Methods: The gene expression profile were analyzed based on data deposited Gene Expression Omnibus (GEO) filtered according brain...

Kaposiform hemangioendothelioma (KHE) is a locally aggressive tumor of vascular origin. This study investigated the clinical and imaging features KHE to provide reference for its early diagnosis.The findings 27 clinically confirmed cases (including 21 with focal lesions 6 diffuse lesions) between January 2016 December 2021 were retrospectively analyzed.The mean age patients was 105 ± 80.27 days. Twenty-two (81.5%) these had Kasabach-Merritt phenomenon. Most KHEs located in trunk and/or...

Medulloblastoma (MB) is a type of malignant brain tumor in children. Although knowledge MB increasing and the survival rate patients with has improved previous years, long-term treatment-associated complications remain unfavorable. Early diagnosis treatment critical for MB, but effective molecular markers elusive. The Speckle-type POZ protein (SPOP) member MATH-BTB family joint molecule Cullin-3. SPOP inhibits growth. However, SPOP-like (SPOPL) gene, which paralog gene shares an overall 85%...

For complex and unstable scapular fractures requiring simultaneous fixation of the glenoid neck, lateral margin body, and/or diaphysis, reconstruction locking plate is difficult to achieve satisfactory fixation. In order optimize effect, newly designed claw-shaped bone was for fixing such fractures. We also evaluate clinical effects follow-up at an average 1 year after treatment in internal by using body neck fracture.A retrospective study conducted from 2018 2021, thirty-three patients (27...

Due to improvement of instrumentation and surgeons' skills, the correction congenital biliary tract anomalies has been performed by laparoscopic approach. Because high rate associated malignancy system in middle-aged adults, treatment for choledochal cyst is necessary, especially adult patients. We report on excision hepaticoduodenostomy type I cysts five To facilitate procedure, creation a Roux-en-Y reconstruction was with minimal abdominal incision. All patients had an uneventful recovery...

Objective:To investigate risk factors of death in newborns with congenital diaphragmatic hernia (CDH). Method:A total 126 CDH from June 2012 to September 2018 were enrolled. Concomitant malformations recorded by descriptive analysis. Newborns received surgical treatment (n=120) for divided into survival group and fatal group. The analyzed univariate multivariate logistic regression the ROC curve generated relevant variables. Result:There 55 concomitant (43.7%), including 20 cases (15.9%)...

Objective To evaluate a new type of adult scapular anatomical locking plate which was designed for fixation the major fracture fragment based on characteristics location and posterior surgical approach. Methods The Computed Tomography (CT) data scapula were collected this study 80 normal adults who had undergone CT scanning from January 2015 to 2018 at Department Orthopedics, Hanzhong Central Hospital. They 43 males 37 females. 3D models reconstructed using by computer. After neck...

Abstract BACKGROUND Glioblastoma (GBM) is the most malignant tumor in central nervous system. It has been confirmed that prognosis of GBM obvious gender predilection. As female patients have an advantage than males, it increasingly accepted to take into account while treating GBM. Therefore, important figure out molecular mechanisms related METHODS We first analyzed protein expression (Male=24, Female=16) based on dataset from Clinical Proteomic Tumor Analysis Consortium (CPTAC) National...

Objective To investigate the effect of FoxM1 inhibitor thiostrepton on proliferation and apoptosis Daoy cell line in medulloblastoma.Methods cells from medulloblastoma were routinely cultured vitro,and they treated with at various concentrations (0,1,1.5,2,3 5 μmol/L); mRNA protein levels detected by real-time PCR Western blotting 48 h after treatment; was investigated using CCK-8 assay 24,48 72 flow cytometry used to observe changes cycle effects apoptosis-relating proteins Bcl-2 Bax...

Objective To investigate the effects of FoxM 1 inhibition by thiostrepton on CDDP chemosensitivity in medulloblastoma Daoy cells.Methods Medulloblastoma cells were cultured vitro; inhibitory rates after treatments 1,1.25,1.5,1.75,2,3,5 μmol/L (thiostrepton treatment groups),or 1,2,3,4,5,10,20 and 40 (CDDP groups) or combined with cDDP (combination evaluated CCK8 assay,and interaction between was analyzed means Jin's formulatin.According to analysis results,Daoy treated (1 μmol/L) (3...

Abstract BACKGROUND: Previously, we reported a case of familial medulloblastoma without hereditary tumor syndrome. Through analysis the whole genome sequencing family members, found common germline WTX (c.1863C>T, p.Gly435Asp) mutation in this family: cytosine (C) at position 63411863 on X chromosome was replaced by thymine (T), and corresponding amino acid glycine Gly (G) 435, which converted to aspartic Asp (D). We conduct study explore biological significance cell lines. METHODS:...