A5101598160- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Genomics and Chromatin Dynamics
- Plant and Fungal Interactions Research
- Botanical Research and Chemistry
- Cancer, Stress, Anesthesia, and Immune Response
- Microtubule and mitosis dynamics
- Gastric Cancer Management and Outcomes
- Genetic diversity and population structure
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- Streptococcal Infections and Treatments
- TGF-β signaling in diseases
- Plant Taxonomy and Phylogenetics
Shanghai Zhangjiang Laboratory
2024
China Pharmaceutical University
2023-2024
Ningbo University
2024
State Key Laboratory of Natural Medicine
2023
Ningbo First Hospital
2019-2021
Huaqiao University
2021
Wuhu No 1 People's Hospital
2021
Huazhong University of Science and Technology
2006-2020
Union Hospital
2019-2020
Wuhan University
2020
Organoids are approved by the US FDA as an alternative to animal experiments guide drug development and for sensitivity screening. Stable organoids models of gastric cancer desirable personalized medicine Tumor tissues from a primary stomach metastatic lymph node were collected 3D culture. By long-term culture over 50 generations in vitro, we obtained stably growing organoid lines. We analyzed short tandem repeats (STRs) karyotypes cells, tumorigenesis nude mice, well multi-omics profiles...
In this work, we propose Reinforced Functional Token Tuning (RFTT), a novel reinforced fine-tuning framework that empowers Large Language Models (LLMs) with self-play learn-to-reason capabilities. Unlike prior prompt-driven reasoning efforts, RFTT embeds rich set of learnable functional tokens (e.g., <analyze>, <verify>, <refine>) directly into the model vocabulary, enabling chain-of-thought construction diverse human-like behaviors. Specifically, comprises two phases: (1) supervised...
Abstract Transcatheter arterial embolization (TAE) plays an important role in clinical liver tumor therapy. However, hypoxia after TAE limit the medium-long term efficacy of TAE. Thus, our study, we explored treatment effect and mechanism combining transcatheter with adopted iodized oil containing Apatinib on suppressing growth metastasis. We simulated changing microenvironment before both vitro vivo models. The anti-angiogenic was by bioassays human umbilical vein endothelial cells...
The tumor promoting roles of long noncoding RNA (lncRNA) MALAT1 have been revealed in various cancers; however, its esophageal squamous cell carcinoma (ESCC) not previously disclosed. In this study, we found that expression was remarkably increased ESCC cells compared to normal human epithelial cells. addition, knockdown attenuated the stemness cells, as evidenced by a decrease spheroid formation capacity, marker and aldehyde dehydrogenase 1 activity. Moreover, decreased migration ability...
Myocyte apoptosis and oxidative stress key critical roles in the process of doxorubicin (DOX)‑induced cardiotoxicity. However, how arise DOX‑induced heart injury remains largely unknown. Cathepsin B (CTSB) is a typical lysosomal cysteine protease that associated with apoptosis, inflammatory responses, autophagy. The present study aimed to investigate role CTSB its potential mechanism. H9C2 cells were infected adenovirus or transfected small interfering RNA overexpress knock down CTSB,...
The aim of the investigation was to evaluate variations in blood TNF-related apoptosis-inducing ligand (TRAIL) levels between patients with viral and bacterial infections diagnostic performance TRAIL for identifying infections.
Expression of the F‐box protein FBXO11 has been shown to be down‐regulated in various tumors, but its role hepatocellular carcinoma (HCC) progression remains unclear. Here, we examined HCC cell stemness. We report that expression is significantly decreased cells, and overexpression stemness markers, ALDH1 activity sphere‐forming ability. In addition, reduced migration ability epithelial‐mesenchymal transition cells. Mechanistically, level, not mRNA Snail by directly interacting with...
High-mobility group AT-hook2 (HMGA2), serving as an architectural transcription factor, participates in plenty of biological processes. Our study is aimed at illustrating the effect HMGA2 on hypoxia-induced HUVEC injury and underlying mechanism. To induce hypoxia-related cell injury, HUVECs were exposed to hypoxic condition for 12–24 h. Molecular expression was determined by Western blot analysis, real-time PCR immunofluorescence staining. Cell migration monitored wound healing assay...
Early cancer detection is the key to a positive clinical outcome. While number of early diagnostics methods exist in clinics today, they tend be invasive and limited few types. Thus, clear need exists for non-invasive that can used detect presence any type. Liquid biopsy based on analysis molecular components peripheral blood has shown significant promise such pan-cancer diagnostics; however, existing this approach require improvements, especially sensitivity early-stage detection. The...
Abstract The promoting roles of the transcriptional regulator SMAR1 have been revealed in several tumors, such as colorectal and breast cancer, however, its osteosarcoma (OS) progression are still confusing. Here, we find that expression is positively correlated with overall survival OS patients negatively stemness markers by analyzing online datasets. Through different Gene Expression Omnibus (GEO) datasets, found to be lowly expressed tissues relative adjacent tissues. Functional...
Hickory (Carya cathayensis Sarg.) is an important economic plant and native to Anhui Zhejiang Province, China. The complete chloroplast (cp) genome sequence of C. was determined by Next-generation sequencing technology. total length the cp 160,666 bp contains 86 protein-coding genes, 39 tRNA 8 rRNA genes. Phylogenetic analysis suggested that Carya sister group genus Annamocarya within walnut family. DNA data presented here will be useful study genetic diversity conservation genetics cathayensis.
Cancer stem cell (CSC) has been confirmed to trigger tumor occurrence and progression CSC can develop strategies maintain a lower reactive oxygen species (ROS) level compared cancer cells. However, the mechanisms contributing ROS homeostasis in are still lacking key elements. In current study, we found that reductive redox states levels were suppressed non-adherent spheres formed by non-small lung (NSCLC) cells, which hold CSC-like traits. mitochondria DNA content cellular consumption rate...
Ormosia hosiei is a critically Endangered and important economic plant which endemic in southern, eastern central China. The complete chloroplast (cp) genome sequence of O. was determined by Next-generation sequencing technology. Total length the cp 172,210 bp, contained large single-copy (LSC) small single copy (SSC), separated inverted repeats (IR) 40,377 bp. cpDNA structured with 144 genes, comprising 98 protein-coding 38 tRNA 8 rRNA genes. Phylogenetic analysis suggested that closely...