A5060804377- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Treatments and Studies
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Viral-associated cancers and disorders
- Urologic and reproductive health conditions
- Circular RNAs in diseases
- Plant Parasitism and Resistance
- Renal and related cancers
- Cervical Cancer and HPV Research
- HVDC Systems and Fault Protection
- Genetic factors in colorectal cancer
- Bioinformatics and Genomic Networks
- Urinary Tract Infections Management
- Viral Infectious Diseases and Gene Expression in Insects
- Gene expression and cancer classification
- Diabetes and associated disorders
- Ferroptosis and cancer prognosis
- Atherosclerosis and Cardiovascular Diseases
- interferon and immune responses
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Plant-Microbe Interactions and Immunity
Zhejiang Shuren University
2024-2025
City University of Hong Kong
2019-2024
Chinese University of Hong Kong
2022-2024
Daping Hospital
2023
Army Medical University
2023
Minzu University of China
2023
City University of Hong Kong, Shenzhen Research Institute
2021
Zhejiang University
2014
State Key Laboratory of Rice Biology
2014
China National Rice Research Institute
2014
Abstract Molecular subtyping of cancer is a critical step towards more individualized therapy and provides important biological insights into heterogeneity. Although gene expression signature-based classification has been widely demonstrated to be an effective approach in the last decade, widespread implementation long limited by platform differences, batch effects, difficulty classify individual patient samples. Here, we describe novel supervised framework, deep subtype (DeepCC), based on...
Abstract The discovery of STING-related innate immunity has recently provided a deep mechanistic understanding immunopathy. While the detrimental effects STING during sepsis had been well documented, exact mechanism by which causes lethal remains obscure. Through single-cell RNA sequence, genetic approaches, and mass spectrometry, we demonstrate that promotes sepsis-induced multiple organ injury inducing macrophage ferroptosis in cGAS- interferon-independent manner. Mechanistically, Q237,...
Pseudomonas syringae, a Gram-negative plant pathogen, expresses multitudinous transcriptional regulators to control the type III secretion system (T3SS) and response diverse environmental challenges. Although mechanisms of virulence-associated P. syringae have been studied for decades, overall crosstalk underlying these is still elusive. Here, we identify five T3SS (EnvZ-OmpR, CbrAB2, PhoPQ, PilRS, MgrA), find that two-component systems EnvZ-OmpR CbrAB2 negatively regulate T3SS. To elucidate...
The latent infection by herpes virus type 1 (HSV-1) may be lifelong in trigeminal ganglia and a suspected cause of Alzheimer's Disease (AD) Amyotrophic lateral sclerosis (ALS). Whether how N6-methyladenosine (m6A) modification viral RNAs affects are poorly understood. Here, we report that HSV-1 enhanced the expression m6A writers (METTL3, METTL14) readers (YTHDF1/2/3) at early stage decreased their later on, while suppressed erasers' (FTO, ALBKH5) immediately upon to facilitate replication....
Noninvasive detection of early-stage disease is a key strategy for reducing gastric cancer (GC)-associated patient mortality.To establish novel, noninvasive, microRNA (miRNA)-based signature the early GC using comprehensive biomarker discovery approach with retrospective and prospective validation.This diagnostic study was conducted in 4 phases publicly available genome sequences tissue samples from patients at an academic medical center Japan, validated multicenter cohorts GC. Three miRNA...
Insect resistance to Bacillus thuringiensis (Bt) crystal protein is a major threat the long-term use of transgenic Bt crops. Gene stacking readily deployable strategy delay development insect while it may also broaden insecticidal spectrum. Here, we report creation rice expressing discrete Cry1Ab and Cry2Ab simultaneously from single expression cassette using 2A self-cleaving peptides, which are autonomous elements virus guiding polycistronic viral gene in eukaryotes. The synthetic coding...
Consensus Molecular Subtype (CMS) classification of colorectal cancer (CRC) tissues is complicated by RNA degradation upon formalin-fixed paraffin-embedded (FFPE) preservation. Here, we present an FFPE-curated CMS classifier. The CMSFFPE classifier was developed using genes with a high transcript integrity in FFPE-derived RNA. We evaluated the accuracy two FFPE-RNA datasets matched fresh-frozen (FF) data, and FF-derived set. An application cohort metastatic CRC patients established, partly...
Abstract Active LINE-1 (L1), Alu , and SVA mobile elements in the human genome are capable of retrotransposition, resulting novel element insertions (MEIs) both germline somatic tissues. Detecting MEIs through DNA sequencing relies on supporting reads overlapping MEI junctions; however, artifacts from amplification, sequencing, alignment errors produce numerous false positives. Systematic detection MEIs, particularly those with low mosaicism, remains a significant challenge. Previous methods...
Cervical cancer is one of the most common gynecological malignancies and has a great impact on women's health. intraepithelial neoplasia (CIN) precancerous lesion cervical closely related to each other. Therefore, early detection treatment can effectively prevent occurrence development cancer. TCM CIN advantages less side effects high safety. In this study, through collating understanding in TCM, diagnosis CIN, we explore methods, at same time, effective prevention cancer, provide reference...
It is known that pulmonary vascular leakage, a key pathological feature of sepsis-induced lung injury, largely regulated by perivascular cells. However, the underlying mechanisms have not been fully uncovered. In present study, we aimed to evaluate role isthmin1, secretory protein originating from alveolar epithelium, in leakage during sepsis and investigate regulatory isthmin1 gene transcription. We observed an elevated expression tissue septic mice induced cecal ligation puncture (CLP), as...
Abstract Purpose Urine proteome is a valuable reservoir of biomarkers for disease diagnosis and monitoring. Following formation as the plasma filtrate in kidney, urine progressively modified by active reabsorption secretion urinary tract. However, little known about how changes it passes along Experimental design To investigate this, we compared composition renal pelvis (RPU) individually self‐voided bladder (BU) collected from seven unilateral tract obstruction male patients LC‐MS/MS...
Abstract Urine proteome is a valuable reservoir of biomarkers for disease diagnosis and monitoring. Following its formation as the plasma filtrate in kidney, urine progressively modified by active reabsorption secretion cells lining urinary tract. However, little known about how changes it passes along To investigate this, we compared composition renal pelvis (RPU) individually self-voided bladder (BU) collected from 7 one-side tract obstruction male patients. While no exclusive proteins...