The precise identification of retinal disorders is utmost importance in the prevention both temporary and permanent visual impairment. Prior research has yielded encouraging results classification images pertaining to a specific condition. In clinical practice, it not uncommon for single patient present with multiple concurrently. Hence, task classifying into labels remains significant obstacle existing methodologies, but its successful accomplishment would yield valuable insights diverse...

Purpose To determine the distributions and relation of central corneal thickness (CCT) intraocular pressure (IOP) by NT-530P in Chinese juveniles, effect gender, age, height, weight refractive errors on CTT IOP. Methods CCT IOP 982 eyes 514 juveniles aged from 7 to 18 years were measured with NT-530P. Multi-linear regression ANOVA analysis used analyze IOP, weight, condition respectively. Results The mean 554.19±35.46 µm 15.31±2.57 mmHg. There significant correlations between values. Linear...

Diabetic retinopathy grading plays a vital role in the diagnosis and treatment of patients. In practice, this task mainly relies on manual inspection using human visual system. However, system-based screening process is labor-intensive, time-consuming, error-prone. Therefore, plenty automated technique have been developed to address task. Among these techniques, deep learning models demonstrated promising outcomes various types machine vision tasks. most medical image analysis-oriented...

To assess the accuracy of Plusoptix A09 photoscreener in detecting amblyopia risk factors children and determine referral criteria when using for a large-scale vision screening.Pediatric patients attending our eye clinic underwent comprehensive ophthalmic examination that included photorefraction, orthoptic examination, anterior segment assessment, fundus cycloplegic retinoscopy. The measurements were collected statistical analyses.One hundred seventy-eight (mean age ± SD: 6.2±2.4 years,...

Purpose: To evaluate the therapeutic efficacy of conbercept for treatment diabetic macular edema (DME) with different baseline visual acuity.Methods: This is a retrospective, comparative study. A total 107 eyes patients were included. According to levels best corrected acuity (BCVA) and regimen, DME divided into four groups: subgroup worse VA (less than 69 letters, Snellen equivalent, 20/50 or worse; n = 37), untreated VA(n 28); better (78 20/32 20/40; 25), (n 17). Patients received one...

Diabetic retinopathy (DR) occurs in almost all patients with diabetes and remains as one of the major causes vision loss worldwide. Nevertheless, molecular mechanisms underlying pathogenesis DR remain elusive. The present study aimed to investigate role association Notch signaling NADPH oxidase 4 (Nox4)‑mediated oxidative stress high glucose (HG)‑treated retinal cells. Human endothelial cells were cultured for various durations RPMI‑1640 medium containing 30 mM (HG) or mannitol (MN) an...

Abstract Vascular endothelial growth factor (VEGF) and placental (PlGF) plays a crucial role in breakdown of the blood-retinal barrier due to hyperpermeability diabetic retinopathy (DR). However, distinct signaling driven by VEGF PlGF pathogenesis DR remains unclear. In this study, we investigated VEGF- PlGF- related pathways their roles cultured human microvascular retinal cells (hRECs) under high glucose conditions (HG; 25 mM). Apoptotic cell death was evaluated, FITC conjugated bovine...

To investigate the prevalence and risk factors for pterygium in rural older adults Shandong Province, eastern China, a population-based, cross-sectional study was performed from April to July 2008. By means of cluster random sampling methods, total 19,583 people aged 50 years or above were randomly selected four counties. Out people, 1,767 residents excluded mainly because they migrant workers when this performed. Finally, 17,816 (90.98%) included as eligible subjects. They received...

Multi-spectral imaging (MSI) is a novel non-invasive tool for visualizing the entire span of eye, from internal limiting membrane to choroid. However, spatial misalignments can be frequently observed in sequential MSI images because eye saccade movement usually faster than image acquisition speed. Therefore, registering necessary computer-based analysis retinal degeneration via MSI. In this paper, we propose an early deep learning framework achieving accurate registration group-wise fashion....

Multispectral imaging (MSI) provides a sequence of en-face fundus spectral slices and allows for the examination structures signatures throughout thickness retina to characterize diabetic retinopathy (DR) lesions comprehensively. Manual interpretation MSI images is commonly conducted by qualitatively analyzing both spatial properties multiple slices. Meanwhile, there exist few computer-based algorithms that can effectively exploit information diagnosis DR. We propose new approach quantify...

Cholesterol-containing soft drusen and subretinal drusenoid deposits (SDDs) occur at the basolateral apical side of retinal pigment epithelium (RPE), respectively, in chorioretina are independent risk factors for late age-related macular degeneration (AMD). Cholesterol these could originate from RPE as nascent HDL or apoB-lipoprotein. We characterized cholesterol efflux apoB-lipoprotein secretion cells. Human cells, ARPE-19, formed that was similar physicochemical properties to by other cell...

Background/Aims: Nonalcoholic steatohepatitis includes steatosis along with liver inflammation, hepatocyte injury and fibrosis. In this study, we investigated the protective role potential mechanisms of a traditional Chinese medicine ShenFu (SF) preparation in an vitro hepatic model. Methods: palmitic acid (PA)-induced murine AML12 cell injury, effects SF on cellular apoptosis intracellular triglyceride (iTG) level were assessed using TUNEL TG Colorimetric Assay. Reactive oxygen species...

Skin Cancer, which leads to a large number of deaths annually, has been extensively considered as the most lethal tumor around world. Accurate detection skin cancer in its early stage can significantly raise survival rate patients and reduce burden on public health. Currently, diagnosis relies heavily human visual system for screening dermoscopy. However, manual inspection is laborious, time-consuming, error-prone. In consequence, development an automatic machine vision algorithm...

Multispectral Imaging (MSI) produces a sequence of discrete spectral slices that penetrate different light-absorbing species or chromophores and is noninvasive technology useful for the early detection various retinal, optic nerve choroidal diseases. However, eye movement during image acquisition process may introduce spatial misalignment between MSI images. This potentially causes trouble in manual/automatic interpretation MSI, but still remains an unresolved problem to this date. To deal...

Aims. To confirm the therapeutic efficacy of conbercept for treatment macular edema (ME) secondary to retinal vein occlusion (RVO) by using optical coherence tomography angiography (OCTA) and find out differences in between ischemic nonischemic (iRVO or non-iRVO) after treatment. Methods. In this prospective, randomized, comparative study, 60 unilateral eyes suffered from RVO combined with were included fellow eye as controls. After an initial intravitreal injection (IVIC), a pro re nata...

In this paper, we introduce a novel feature-point-matching based framework for achieving an optimized joint-alignment of sequential images from multispectral imaging (MSI). It solves low-rank and semidefinite matrix that stores all pairwise-image feature-mappings by minimizing the total amount point-to-point matching cost via convex optimization programming formulation. This unique strategy takes complete consideration information aggregated point-matching costs enables entire set to be...

Multicolor (MC) imaging is an modality that records confocal scanning laser ophthalmoscope (cSLO) fundus images, which can be used for the diabetic retinopathy (DR) detection. By utilizing this technique, multiple modal images obtained in a single case. Additional symptomatic features if these are considered during diagnosis of DR. However, few studies have been carried out to classify MC Images using deep learning methods, let alone multi analysis. In work, we propose novel model uses...

Abstract Background To compare vitreous angiomosaic images (VAMIs), obtained by widefield swept-source optical coherence tomographic angiography (wfSS-OCTA) and the image of fluorescein fundus (FFA) in identification retinal neovascularization (NV) patients with diabetic retinopathy (DR). Methods In this prospective observational study, severe non-proliferative (NPDR) or proliferative DR (PDR) were included. All underwent FFA wfSS-OCTA. The number NVs identified wfSS-OCTA VAMIs using five...