A5037293264- Pancreatic function and diabetes
- Diabetes and associated disorders
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Signaling Pathways in Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Genetics and Neurodevelopmental Disorders
- Nausea and vomiting management
- Endoplasmic Reticulum Stress and Disease
- Selenium in Biological Systems
- Neonatal Health and Biochemistry
- Hemodynamic Monitoring and Therapy
- Intracranial Aneurysms: Treatment and Complications
- Studies on Chitinases and Chitosanases
- Trace Elements in Health
- Genomics and Chromatin Dynamics
- Diet, Metabolism, and Disease
- S100 Proteins and Annexins
- Autophagy in Disease and Therapy
- Galectins and Cancer Biology
- Pancreatitis Pathology and Treatment
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Chromatin Remodeling and Cancer
- Heavy Metal Exposure and Toxicity
Sichuan University
2024-2025
West China Hospital of Sichuan University
2024-2025
Zhejiang University
2017-2024
Second Affiliated Hospital of Zhejiang University
2022-2024
University of Chinese Academy of Sciences
2022-2024
National Center for Drug Screening
2022
Shanghai Institute of Materia Medica
2022
Shenzhen University
2012-2013
In diabetes, macrophages and inflammation are increased in the islets, along with β-cell dysfunction. Here, we demonstrate that galectin-3 (Gal3), mainly produced secreted by macrophages, is elevated islets from both high-fat diet (HFD)-fed diabetic db/db mice. Gal3 acutely reduces glucose-stimulated insulin secretion (GSIS) lines primary mice humans. Importantly, binds to calcium voltage-gated channel auxiliary subunit gamma 1 (CACNG1) inhibits influx via cytomembrane subsequent GSIS....
Pancreatic β cell plasticity is the primary determinant of disease progression and remission type 2 diabetes (T2D). However, dynamic nature adaptation remains elusive. Here, we establish a mouse model exhibiting compensation-to-decompensation function in response to increasing duration high-fat diet (HFD) feeding. Comprehensive islet functional transcriptome analyses reveal orchestration transcriptional networks featuring temporal alteration chromatin remodeling. Interestingly, prediabetic...
Impeded autophagy can impair pancreatic β cell function by causing apoptosis, of which DAP-related apoptosis-inducing kinase-2 (DRAK2) is a critical regulator. Here, we identified marked up-regulation DRAK2 in tissue across humans, macaques, and mice with type 2 diabetes (T2D). Further studies showed that conditional knockout (cKO) cells protected against high-fat diet feeding along sustained mitochondrial function. Phosphoproteome analysis isolated mouse primary islets revealed directly...
Leukocytes play an important role in inflammatory response after a traumatic brain injury (TBI). We designed this study to identify TBI phenotypes by clustering blood levels of various leukocytes. patients from the Medical Information Mart for Intensive Care-III (MIMIC-III) database were included. Blood neutrophils, lymphocytes, monocytes, basophils, and eosinophils collected analyzing first sample within 24 h since admission. Overall, divided into clusters following K-means method using...
Bilirubin plays a crucial role in the pathophysiological processes of strokes. However, relationship between serum bilirubin levels and prognosis aneurysmal subarachnoid hemorrhage (aSAH) remains unexplored. This study aims to investigate association mortality rate aSAH patients. 695 patients were included analyze direct (DBil), indirect (IDBil), total (TBil), mortality. The univariate multivariate logistic regression conducted discover risk factors for aSAH. restricted cubic spline (RCS)...
Selenoprotein M (SelM), one of the executants selenium in vivo, is highly expressed human brain and most probably involved antioxidation, neuroprotection, intracellular calcium regulation, which are key factors for preventing onset progression Alzheimer's disease (AD). In this paper, SelM was successfully overexpressed embryonic kidney cells HEK293T. Sodium selenite (Na(2)SeO(3) 0.5 μmol/L) increased expression full-length inhibited truncated SelM. The exhibited higher antioxidant activity...
Background: Traumatic brain injury (TBI) patients suffer high risks of mortality. Ondansetron has been verified to be effective in improving the prognosis some kinds critically ill patients. We design this study explore whether ondansetron use is associated with lower mortality among TBI Methods: from Medical Information Mart for Intensive Care-III were collected. The usage ondansetron, including intravenous injection and oral tablet, since admission Beth Israel Deaconess Center between 2001...
Background Coagulopathy is associated with poor prognosis of traumatic brain injury (TBI) patients. This study performed to explore the association between serum magnesium level and risk coagulopathy in TBI. Methods TBI patients from Medical Information Mart for Intensive Care-III database were included this study. Logistic regression analysis was factors develop a predictive model The restricted cubic spline (RCS) utilized analyze development coagulopathy. Receiver operating characteristic...
Abstract Valosin‐containing protein (VCP) is a type‐II adenosine triphosphatase (ATPase) wih extensive biological function in organisms. Silkworm the second insect model for genetic studies and bioreactor proteinaceous drugs biomaterials. In this paper, new VCP‐like gene was amplified from fat body of silkworm following genome prediction spliced expressed sequence tag sequences, using both reverse transcription polymerase chain reaction (RT‐PCR) 3′‐RACE (rapid amplification complementary DNA...