A5050889907- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Research and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Spondyloarthritis Studies and Treatments
- Cell death mechanisms and regulation
- Sepsis Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Lung Cancer Treatments and Mutations
- Alcohol Consumption and Health Effects
- Intracranial Aneurysms: Treatment and Complications
- S100 Proteins and Annexins
- Cancer Immunotherapy and Biomarkers
Sichuan University
2024-2025
West China Hospital of Sichuan University
2024-2025
Boehringer Ingelheim (United States)
2023
Background. The association between atherogenic index of plasma (AIP) and hyperuricemia remains indistinct. This study was aimed to examine the relationship AIP among middle-aged elderly Chinese population. Methods. Datasets were retrieved from China Health Retirement Longitudinal Study (CHARLS) survey conducted in 2011 2015. 13,021 participants CHARLS 7,017 involved both 2015 included, respectively. measurement based on test fasting blood. Association assessed by logistic regression,...
Leukocytes play an important role in inflammatory response after a traumatic brain injury (TBI). We designed this study to identify TBI phenotypes by clustering blood levels of various leukocytes. patients from the Medical Information Mart for Intensive Care-III (MIMIC-III) database were included. Blood neutrophils, lymphocytes, monocytes, basophils, and eosinophils collected analyzing first sample within 24 h since admission. Overall, divided into clusters following K-means method using...
115 Background: BI 905711 is a tetravalent bispecific antibody that cross-links TRAILR2 with CDH17. This cross-linking drives CDH17-dependent oligomerization, leading to caspase activation and eventual apoptosis, inhibiting tumor growth in preclinical models of GI cancer. Methods: Phase Ia/b study patients (pts) advanced cancers (NCT04137289) aimed determine the maximum tolerated dose (MTD) based on proportion pts dose-limiting toxicities (DLT) explore preliminary antitumor activity. In Ia,...
TPS820 Background: Activation of the tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAILR2) induces apoptosis via extrinsic pathway. Targeting TRAILR2 presents an attractive therapeutic strategy, but some early agonists showed low efficacy or severe hepatotoxicity. BI 905711 (TRAILR2 agonist) is a novel, liver-sparing, tetravalent bispecific antibody that cross-links with membrane protein cadherin 17 (CDH17; highly expressed in GI cancers), inducing CDH17-dependent...
Background Coagulopathy is associated with poor prognosis of traumatic brain injury (TBI) patients. This study performed to explore the association between serum magnesium level and risk coagulopathy in TBI. Methods TBI patients from Medical Information Mart for Intensive Care-III database were included this study. Logistic regression analysis was factors develop a predictive model The restricted cubic spline (RCS) utilized analyze development coagulopathy. Receiver operating characteristic...