A5003863413- Liver Disease Diagnosis and Treatment
- FOXO transcription factor regulation
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Genetics and Neurodevelopmental Disorders
- Peroxisome Proliferator-Activated Receptors
- Diabetes and associated disorders
- MicroRNA in disease regulation
Second Affiliated Hospital of Zhejiang University
2022-2024
Zhejiang University
2024
Pancreatic β cell plasticity is the primary determinant of disease progression and remission type 2 diabetes (T2D). However, dynamic nature adaptation remains elusive. Here, we establish a mouse model exhibiting compensation-to-decompensation function in response to increasing duration high-fat diet (HFD) feeding. Comprehensive islet functional transcriptome analyses reveal orchestration transcriptional networks featuring temporal alteration chromatin remodeling. Interestingly, prediabetic...
Overnutrition has gradually become the primary causative factor in nonalcoholic fatty liver disease (NAFLD). However, how nutritional signals are integrated to orchestrate transcriptional programs important for NAFLD progression remains poorly understood. We identified hepatic BAF60b as a lipid-sensitive subunit of switch/sucrose nonfermentable chromatin-remodeling complex that is negatively associated with steatosis mice and humans. Hepatic deficiency promotes high-fat diet (HFD)–induced...
<p dir="ltr"><b>Abstract</b></p><p dir="ltr"><a href="" target="_blank">Overnutrition has gradually become the primary causative factor of nonalcoholic fatty liver disease (NAFLD)</a>. <a target="_blank">However, how nutritional signals are integrated to orchestrate transcriptional programs important for NAFLD progression remains poorly understood.</a> target="_blank">Here, we identified hepatic BAF60b as a lipid-sensitive subunit...
<p dir="ltr"><b>Abstract</b></p><p dir="ltr"><a href="" target="_blank">Overnutrition has gradually become the primary causative factor of nonalcoholic fatty liver disease (NAFLD)</a>. <a target="_blank">However, how nutritional signals are integrated to orchestrate transcriptional programs important for NAFLD progression remains poorly understood.</a> target="_blank">Here, we identified hepatic BAF60b as a lipid-sensitive subunit...
<p dir="ltr"><b>Abstract</b></p><p dir="ltr"><a href="" target="_blank">Overnutrition has gradually become the primary causative factor of nonalcoholic fatty liver disease (NAFLD)</a>. <a target="_blank">However, how nutritional signals are integrated to orchestrate transcriptional programs important for NAFLD progression remains poorly understood.</a> target="_blank">Here, we identified hepatic BAF60b as a lipid-sensitive subunit...