A5101552414- Spinal Cord Injury Research
- Nerve injury and regeneration
- Nanopore and Nanochannel Transport Studies
- Pancreatic function and diabetes
- Ultrasonics and Acoustic Wave Propagation
- Handwritten Text Recognition Techniques
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Mitochondrial Function and Pathology
- Anesthesia and Neurotoxicity Research
- Non-Destructive Testing Techniques
- Terahertz technology and applications
- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
- Natural Language Processing Techniques
- Peroxisome Proliferator-Activated Receptors
- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- Immune cells in cancer
- Ion-surface interactions and analysis
- Air Quality and Health Impacts
- Metamaterials and Metasurfaces Applications
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Vascular Malformations Diagnosis and Treatment
Huazhong University of Science and Technology
2022-2024
Tongji Hospital
2022-2024
National Clinical Research Center for Digestive Diseases
2024
Hubei Provincial Center for Disease Control and Prevention
2024
National Clinical Research
2024
China Meteorological Administration
2024
Huawei Technologies (United Kingdom)
2024
Zhejiang University
2022-2023
Wuxi People's Hospital
2016-2023
Nanjing Medical University
2023
Significance The role of STING in maintaining glucose homeostasis remains unknown. Herein, using global and β-cell–specific knockout mouse models, we revealed a distinct the regulation through β-cells peripheral tissues. Specially, while beneficially alleviated insulin resistance intolerance induced by high-fat diet, it surprisingly impaired islet glucose-stimulated secretion (GSIS). Further analyses that deficiency down-regulated expression β-cell key transcription factor Pax6, impairing...
Abstract Skeletal muscle and thermogenic adipose tissue are both critical for the maintenance of body temperature in mammals. However, whether these two tissues interconnected to modulate thermogenesis metabolic homeostasis response thermal stress remains inconclusive. Here, we report that human mouse obesity is associated with elevated Musclin levels circulation. Intriguingly, expression markedly increased or decreased when male mice housed thermoneutral chronic cool conditions,...
Isorhamnetin has distinct anti-inflammatory activity and inhibits cell proliferation migration. These effects are also involved in the pathogenesis of asthma. However, effect isorhamnetin on bronchial epithelial cells patients with asthma not been examined. Cells human line BEAS-2B were cultured tumor necrosis factor (TNF)-α. The viability assessed using CCK8 assay. EdU (5-ethynyl-2'-deoxyuridine) assay was performed to assess proliferation. migration measured Transwell wound healing assays....
Pancreatic β cell plasticity is the primary determinant of disease progression and remission type 2 diabetes (T2D). However, dynamic nature adaptation remains elusive. Here, we establish a mouse model exhibiting compensation-to-decompensation function in response to increasing duration high-fat diet (HFD) feeding. Comprehensive islet functional transcriptome analyses reveal orchestration transcriptional networks featuring temporal alteration chromatin remodeling. Interestingly, prediabetic...
Type 2 diabetes (T2D) is an independent risk factor for Alzheimer's disease (AD). Exendin-4 (Ex-4), a widely used glucagon-like peptide-1 receptor agonist drug in the treatment of T2D, has been demonstrated therapeutic effects on diabetic encephalopathy (DE). Especially, Ex-4 ameliorates tau hyperphosphorylation and cognitive impairment DE. And these crucial alterations are also important bridge between T2D AD. However, its unique mechanism unclear.The db/db mice, high-fat-diet (HFD) /...
Progressive tissue necrosis is a process unique to the injured mammalian spinal cord which often leads gradually increasing cavitation and enlargement of lesion. To evaluate role neuronal degeneration in initiating this response, histopathological changes were compared C57BL WldS (delayed Wallerian mutation) mice. The was crushed at T8, producing primary lesion site trauma secondary extending rostrocaudally dorsal columns (where long ascending descending fiber tracts undergo degeneration)....
Cell metabolism generates numerous intermediate metabolites that could serve as feedback and feed-forward regulation substances for posttranslational modification. Lactate, a metabolic product of glycolysis, has recently been conceptualized to play pleiotropic role in shaping cell identities through rewiring epigenetic modifications. Lactate-derived carbons, sourced from glucose, mediate the crosstalk among lactate, lactylation. Furthermore, multiple fates lactate make it an ideal substrate...
Reactive changes in macrophages/microglia and astrocytes were evaluated following spinal cord injury normal mice of the C57BL/6J strain carrying a mutation (Wlds) which delays onset Wallerian degeneration damaged axons. Crush injuries produced at T8 level by using an extradural approach; animals allowed to survive for 2 days 12 weeks, cords prepared immunocytochemistry antibodies against Mac1 glial fibrillary acidid protein (GFAP). In mice, Mac1-positive macrophages accumulated site 4...
Background: Brain-derived neurotrophic factor (BDNF) protects retinal ganglion cells against ischemia in ocular degenerative diseases. We aimed to determine the effect of BDNF-AS on ischemic injury cells. Methods: The levels BDNF and were measured subjected oxygen glucose deprivation. lentiviral vectors constructed either overexpress or knock out BDNF-AS. luciferase reporter gene assay was used whether could target its seed sequence mRNA. methyl thiazolyl tetrazolium cell viability, TUNEL...
Oxidative stress is the main cause of ischemia/reperfusion injury. Propofol a commonly used intravenous hypnotic anesthetic agent with antioxidant properties. In this study, we aimed to elucidate protective effects propofol on H2O2-induced cardiomyocyte injury and myocardial ischemic/reperfusion (MIRI) in rats. Cardiomyocyte was evaluated by determining cardiac troponin-1 (cTn-1) creatine kinase-MB (CK-MB) levels. Antioxidative assessed measuring lactate dehydrogenase (LDH), malondialdehyde...
Tissue destruction at the primary site of a spinal cord injury leads to persistent necrosis that progressively enlarges lesion. Steroids attenuate this necrotizing process and promote tissue repair even though such anti-inflammatory drugs interfere with wound healing in non-CNS organs. To address paradox, rats mice was crushed extradurally effects following agents studied by light microscopical image analysis: allopurinol, aminoguanidine, indomethacin, bacterial lipopolysaccharide, naproxen,...
Thermogenic adipocytes have been extensively investigated because of their energy-dissipating property and therapeutic potential for obesity diabetes. Besides serving as fuel sources, accumulating evidence suggests that intermediate metabolites play critical roles in multiple biological processes. However, role adipocyte differentiation thermogenesis remains unexplored. Here, we report human mouse is associated with marked downregulation glutamine synthetase (Glul) expression activity...
Disabled-2 (Dab2) is considered a tumor suppressor and downregulated in cancers. We examined the promoter methylation status expression levels of Dab2, investigated their roles development lung Methylation-specific PCR was employed to analyze Dab2 100 cancer tissues. The cytoplasmic nuclear protein determined using western blot analysis. Demethylation treatment 5-Aza-2-deoxycytidine (5-Aza-dC) performed three cell lines. upregulated by transfection or interrupted siRNA cells. Proliferative...
Adipose tissue macrophage (ATM) has been shown to play a key role in the pathogenesis of obesity-associated adipose inflammation and metabolic diseases. However, upstream factors that integrate environmental signals control ATM activation obesity remain elusive. Here, we identify BAF60a, subunit switch/sucrose-nonfermentable (SWI/SNF) chromatin remodeling complexes, as central checkpoint regulator obesity-induced activation, inflammation, systemic impairment. BAF60a expression was robustly...
Graphene-based nanopore devices have shown tantalizing potential in single molecule detection for their monoatomic membrane thickness which is roughly equal to the gap between nucleobases. However, high noise level hampers applications of graphene sensors, especially at low frequencies. In this article, we report on a study contribution suspended area full frequency band. Monolayer films are transferred onto SiNx substrates preset with holes varied diameters and formed self-supported films....