A5103193691- Plant Molecular Biology Research
- Adipose Tissue and Metabolism
- Global Public Health Policies and Epidemiology
- Photosynthetic Processes and Mechanisms
- Nutritional Studies and Diet
- COVID-19 epidemiological studies
- Plant Pathogens and Fungal Diseases
- Cancer, Hypoxia, and Metabolism
- Plant Physiology and Cultivation Studies
- Flowering Plant Growth and Cultivation
- Radiomics and Machine Learning in Medical Imaging
- Polysaccharides and Plant Cell Walls
- Plant Stress Responses and Tolerance
- Animal Virus Infections Studies
- COVID-19 Pandemic Impacts
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Nutrition and Health in Aging
- Plant responses to water stress
- Light effects on plants
- Air Quality and Health Impacts
- AI in cancer detection
- Peroxisome Proliferator-Activated Receptors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Viral gastroenteritis research and epidemiology
First Affiliated Hospital of Wannan Medical College
2022-2025
Novogene Bioinformatics Institute
2025
South China Agricultural University
2021-2025
Northwest A&F University
2024
Zhejiang University
2023
Second Affiliated Hospital of Zhejiang University
2020-2023
Hangzhou Normal University
2020-2023
University of Toronto
2023
Wannan Medical College
2022
North China University of Science and Technology
2021-2022
Abstract Diabetes mellitus is a leading cause of mortality and reduced life expectancy. We aim to estimate the burden diabetes by type, year, regions, socioeconomic status in 195 countries territories over past 28 years, which provide information achieve goal World Health Organization Global Action Plan for Prevention Control Noncommunicable Diseases 2025. Data were obtained from Burden Disease Study 2017. Overall, global had increased significantly since 1990. Both trend magnitude related...
Background Low bone mineral density (LBMD), including osteoporosis and low mass, has becoming a serious public health concern. We aimed to estimate the disease burden of LBMD its related fractures in 204 countries territories over past 30 years. Methods collected detailed information performed secondary analysis for from Global Burden Disease Study 2019. Numbers age-standardized rates disability-adjusted life-years (DALYs) deaths were compared by age, gender, socio-demographic index (SDI),...
Abstract Background Dietary risks have raised attention worldwide during recent decades. The present burden‐of‐disease study aimed to evaluate the global dietary for non‐communicable diseases (NCDs) from 1990 2019 and quantify their impact on mortality disability‐adjusted life‐years (DALYs). Data Global Burden of Disease Study deaths DALYs NCDs attributable were obtained underwent deep analysis by year, age, gender, location, leading causes, associations examined. socio‐demographic index...
Objective To analyze the trends in disease burden of diabetes-related chronic kidney (CKD) by year, age, gender and types diabetes China from 1990 to 2019. Methods Data on prevalence, deaths disability-adjusted life years (DALYs) for CKD were extracted Global Burden Disease (GBD) 2019 study. Analyses performed diabetes. Results In China, numbers DALYs continuously increased but age-standardized rates (per 100,000 population) decreased over 30 years, which attributable type 1 mellitus...
Exosomal PD-L1 (exoPD-L1) has recently received significant attention as a biomarker predicting immunotherapeutic responses involving the PD1/PD-L1 pathway. However, current technologies for exosomal analysis rely primarily on bulk measurements that do not consider heterogeneity found within subpopulations. Here, we present nanoscale cytometry platform NanoEPIC, enabling phenotypic sorting and exoPD-L1 profiling from blood plasma. We highlight efficacy of NanoEPIC in monitoring anti-PD-1...
Floral transition, the change from vegetative growth to reproductive development, is dramatic in flowering plants. Here, we show that one subgroup III member of B-box (BBX) family, BBX17, a repressor floral transition under long-day conditions. BBX17 contains domain and CCT domain. Although phenotype loss-of-function plants was comparable wild-type plants, BBX17-overexpression displayed delayed-flowering The not result an altered CONSTANS (CO) expression level but rather repression FLOWERING...
Obesity and type 2 diabetes (T2D) are the leading causes of progressive decline in muscle regeneration fitness adults. The microenvironment is known to play a key role controlling stem cell regenerative capacity, yet underlying mechanism remains elusive. Here, we found that Baf60c expression skeletal significantly downregulated obese T2D mice humans. Myofiber-specific ablation impairs contraction, accompanied by robust upregulation Dkk3, muscle-enriched secreted protein. Dkk3 inhibits...
Abstract Purpose To assess the trend patterns and gender disparity in global burden of vision loss due to diabetic retinopathy (DR) by year, age, region socioeconomic status using prevalence years lived with disability (YLDs) from Global Burden Disease (GBD) study 2017. Methods Prevalence YLDs data attributable DR were extracted GBD Study 2017 195 countries territories. Socio‐demographic Index (SDI) was cited as indicators status. Kruskal–Wallis test, Dunn’s multiple comparisons Pearson...
Abstract In this study, the chloroplast genome sequencing of Achyranthes longifolia , bidentata and aspera were performed by Next-generation technology. The results revealed that there a length 151,520 bp ( A. ), 151,284 151,486 respectively . These have highly conserved structure with pair inverted repeat (IR) regions (25,150 bp; 25,145 25,150 bp), large single copy (LSC) (83,732 83,933 83,966 bp) small (SSC) (17,252 17,263 17,254 in bidentate, There 127 genes annotated, which including 8...
Thermogenic adipocytes have been extensively investigated because of their energy-dissipating property and therapeutic potential for obesity diabetes. Besides serving as fuel sources, accumulating evidence suggests that intermediate metabolites play critical roles in multiple biological processes. However, role adipocyte differentiation thermogenesis remains unexplored. Here, we report human mouse is associated with marked downregulation glutamine synthetase (Glul) expression activity...
Swine acute diarrhoea syndrome coronavirus (SADS-CoV) is an enveloped, single-stranded positive-sense RNA virus that causes and death in piglets, resulting significant economic losses to the pig farming industry. Studying interaction patterns between SADS-CoV host proteins can provide guidance for development of antiviral drugs. In previous work, we identified 289 interacting with M protein through glutathione S-transferase pull down combined LC-MS/MS. Here, focus on prohibitin (PHB), which...
<title>Abstract</title> Objective This study aimed to construct a nomogram based on body composition parameters and the prognostic nutritional index (PNI) using quantitative computed tomography (QCT) predict early postoperative complications in patients with colorectal cancer (CRC). Materials Methods We retrospectively analyzed data of 157 who underwent radical resection for CRC between January 2019 April 2024. All QCT 1 month prior surgery. Body was assessed at level third lumbar vertebra,...
This study investigates whether deep learning radiomics of conventional ultrasound images can predict preoperative axillary lymph node (ALN) status in patients with clinical stages T1-2 breast cancer (BC).This retrospectively analyzed the data 892 BC, who were classified into training (n=535), validation (n=178), and test (n=179) cohorts. Linear combinations selected features weighted by their coefficients to obtain predicted score. Then, radiomic extracted from evaluate ALN status....
Swine acute diarrhea syndrome coronavirus (SADS-CoV), first discovered in 2017, is a porcine enteric that can cause (SADS) piglets. Here, we studied the role of SADS-CoV nucleocapsid (N) protein innate immunity. Our results showed N could inhibit type I interferon (IFN) production mediated by Sendai virus (Sev) and block phosphorylation nuclear translocation regulatory factor 3 (IRF3). Simultaneously, IFN- β promoter activity TANK binding kinase 1 (TBK1) or its upstream molecules RLRs signal...
Objective: Recently, Nonalcoholic Steatohepatitis (NASH) has become a major contributor to cirrhosis and liver cancer.Therefore, the Global Burden of Disease (GBD) 2017 was used comprehensively analyze global, regional, national burden cancer due NASH between 1990 2017.Methods: Data for were extracted from GBD study 2017.Socio-demographic Index (SDI) in cited as indicators socioeconomic status.ARIMA model established forecast future health burden.Kruskal-Wallis test Pearson linear...
Abstract Background The TGACG-binding (TGA) family has 10 members that play vital roles in Arabidopsis thaliana defense responses and development. However, their involvement controlling flowering time remains largely unknown requires further investigation. Results To study the role of TGA7 during floral transition, we first investigated tga7 mutant, which displayed a delayed-flowering phenotype under both long-day short-day conditions. We then performed genetic pathway analysis found...
Histological grade is an important factor in the overall prognosis of patients with invasive breast cancer. Therefore, non-invasive assessment histological cancer increasing concern for clinicians. We aimed to establish MRI-based radiomics model preoperative prediction grade.We enrolled 901 and pre-operative MRI. Patients were randomly divided into training cohort (n=630) validation (n=271) a ratio 7:3. A signature was constructed by extracting features from MRI images developed according...
Success in plant reproduction is highly dependent on the correct timing of floral transition, which tightly regulated by flowering pathways. In model Arabidopsis thaliana, central repressor FLOWERING LOCUS C (FLC) precisely multiple time regulators vernalization pathway and autonomous pathway, including FPA. Here we report that MEDIATOR SUBUNIT 8 (MED8) promotes transition recruiting FPA to FLC locus repress expression. Loss MED8 function leads a significant late-flowering phenotype due...
Abstract Background Hyperglycemia is a major public health concern. An understanding of the latest trends global burden noncommunicable diseases (NCDs) by high fasting plasma glucose (HFPG) critical for determining research priorities and planning policy. Methods This comparative burden‐of‐disease study. We obtained global, regional, national data on deaths disability‐adjusted life years (DALYs) NCDs attributable to HFPG from Global Burden Disease Study 2017, performed secondary analysis...
In this study, we report a function of myo-inositol-O-methyltransferase (Imt1) in response to low temperature stress using transgenic Arabidopsis thaliana. Imt1 gene was constructed identical the from halophyte Mesembryanthemum crystallinum. After cold stress, plants exhibited stronger growth than wild type plants. The elevated tolerance over-expressing confirmed by lower electrolyte leakage and accumulation malondialdehyde, but higher proline soluble sugar contents
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an enterovirus that can cause and death in piglets serious economic losses to the pig industry. SADS-CoV membrane (M) protein mainly plays a key role biological processes, such as virus assembly, budding, host innate immune regulation. Understanding interaction between M proteins very important define molecular mechanism of cells at level understand specific cellular physiological pathways. In this study, 289 interacting with were...