A5050141231- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Vestibular and auditory disorders
- Neurological disorders and treatments
- Neural dynamics and brain function
- Carcinogens and Genotoxicity Assessment
- EEG and Brain-Computer Interfaces
- Neurology and Historical Studies
- Sleep and Wakefulness Research
- Glioma Diagnosis and Treatment
- Photoreceptor and optogenetics research
- Ophthalmology and Eye Disorders
- Cerebrovascular and Carotid Artery Diseases
- Cerebrospinal fluid and hydrocephalus
- Hearing, Cochlea, Tinnitus, Genetics
- Animal testing and alternatives
- Neuroscience and Neural Engineering
- Polyamine Metabolism and Applications
- Nonmelanoma Skin Cancer Studies
- Genomics, phytochemicals, and oxidative stress
- Botulinum Toxin and Related Neurological Disorders
- Neurobiology and Insect Physiology Research
- Advanced Neuroimaging Techniques and Applications
- Retinal Development and Disorders
- Ion channel regulation and function
Centre National de la Recherche Scientifique
1989-2024
University of California, San Francisco
2018-2024
Institut des Neurosciences Paris-Saclay
2023-2024
CEA Paris-Saclay
2023-2024
Université Paris-Saclay
2023-2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2023-2024
Inserm
1975-2022
Institut de Biologie de l'École Normale Supérieure
2013-2022
Pierre Fabre (France)
2021
École Normale Supérieure - PSL
2013-2021
Journal Article STRIATAL AMINES, EXPERIMENTAL TREMOR AND THE EFFECT OF HARMALINE IN MONKEY Get access L. J. POIRIER, POIRIER Laboratoire des Sciences Neurologiques, Faculté de Médecine, Université MontréalAllan Memorial Institute of Psychiatry, McGill University Search for other works by this author on: Oxford Academic PubMed Google Scholar T. SOURKES, SOURKES G. BOUVIER, BOUVIER R. BOUCHER, BOUCHER S. CARABIN Brain, Volume 89, Issue 1, March 1966, Pages 37–52,...
Children diagnosed with autism spectrum disorder (ASD) commonly present sensory hypersensitivity or abnormally strong reactions to stimuli. Such can be overwhelming, causing high levels of distress that contribute markedly the negative aspects disorder. Here, we identify a mechanism underlies in sensorimotor reflex found altered humans and mice loss function ASD risk-factor gene SCN2A. The cerebellum-dependent vestibulo-ocular (VOR), which helps maintain one's gaze during movement, was...
The Sox family of transcription factors have been widely studied in the context oligodendrocyte development. However, comparatively little is known about role Sox2, especially during CNS remyelination. Here we show that expression Sox2 occurs progenitor cells (OPCs) rodent models myelination and activated adult OPCs responding to demyelination, also detected multiple sclerosis lesions. In normal white matter both mice rats, it neither expressed by nor oligodendrocytes (although a...
Summary: The concordance between the epileptogenic area as determined by intracranially recorded spontaneous seizure onset and that electrically induced auras or seizures in 126 patients with medically intractable epilepsy was studied. Four to 11 multicontact depth electrodes were chronically implanted part of a preoperative investigation procedure. Local‐ ization epileptic obtained from record‐ ing three stimulation data including self‐reported auras, seizures, intracra‐ nial EEG...
In two cases, depth electrode studies and behavioral recordings indicated that headache was a clinical manifestation of ictal activity. The epileptogenic focus found in the right limbic system, temporal lobectomy relieved headaches.
IN previous studies in the monkey, it was observed that there is a direct relationship betwen interruption of ascending nervous fibers at level ventromedial area upper brain stem, retrograde cellular degeneration ipsilateral substantia nigra,<sup>1</sup>and depletion dopamine both parts homolateral striatum.<sup>2-4</sup>Similarly, serotonin striatum attributed to most dorsomedial cerebral peduncle on corresponding side.<sup>5,6</sup>These neuroanatomical and neurochemical changes are...
Abstract A morphological study of the red nucleus and its efferent nervous pathways based on retrograde cellular degeneration (cell loss) degenerated fibers impregnated with osmic acid gave folowing results. Interruption rubro‐tegmentospinal tract was associated a complete disappearance cells in contralateral magnocellular some cell loss adjoining tegmental gray. central bundle results parvicellular part ipsilateral nucleus. Such lesion is rubro‐olivary that terminate along dorsal lamella...
Significance T-type calcium channels are present in the spines of a number principal neurons. In absence specific antagonists, their function has been difficult to elucidate. At cerebellar synapse between parallel fiber (PF) and Purkinje cell (PC), postsynaptic Ca 2+ signaling is not result ionotropic glutamatergic receptor activation, while V 3.1 abundantly expressed PCs. We show that they required for long-term potentiation but depression at PF–PC synapses. Because plasticity this site...
Numerous studies have shown that cerebellar function is related to the plasticity at synapses between parallel fibers and Purkinje cells. How specific input patterns determine outcomes, as well biophysics underlying of these synapses, remain unclear. Here, we characterize activity lead postsynaptically expressed LTP using both in vivo vitro experiments. Similar requirements LTD, find high-frequency bursts are necessary trigger this burst-dependent depends on presynaptic NMDA receptors nitric...
The cerebellum aids the learning of fast, coordinated movements. According to current consensus, erroneously active parallel fibre synapses are depressed by complex spikes signalling movement errors. However, this theory cannot solve
We studied 24 patients who had adversion as the first clinical manifestation of seizures. Seizures were recorded with depth electrodes part evaluation for possible surgery epilepsy. Head rotation did not help to lateralize epileptic focus clinically, because deviations occurred ipsilaterally EEG in some patients, and head either direction despite a unifocal epileptogenic abnormality. Furthermore, no cortical localization was consistently linked or degree adversion. Adversion has consistent...
Long-term synaptic plasticity is believed to be the cellular substrate of learning and memory. Synaptic rules are defined by specific complement receptors at synapse associated downstream signaling mechanisms. In young rodents, cerebellar between granule cells (GC) Purkinje (PC), bidirectional shaped balance transcellular nitric oxide (NO) driven presynaptic N-methyl-D-aspartate receptor (NMDAR) activation postsynaptic calcium dynamics. However, role location NMDAR in these pathways still...
Essential oils (EOs) are increasingly consumed as food supplements. The few published recommended doses available generally lack details both on the methodology used and concentration limits for substances of concern, including genotoxic carcinogens. We propose a tiered approach based toxicological evaluation maximized concentrations each constituent present in EO investigated. potential is assessed using literature data or QSAR analyses. Genotoxic constituents evaluated according to...
Abstract Traditional life‐style, especially food habits, infection by Ep‐stein‐Barr virus (EBV) and genetic factors, have been associated with an increased risk of nasopharyngeal carcinoma (NPC). N ‐Nitroso compounds other carcinogens either present in or formed endogenously, as well constituents that activate EBV, suspected etiological factors NPC pathogenesis. For their characterization preserved items, frequently consumed endemic areas Tunisia, South China Greenland, were sampled screened...
N-methyl-D-aspartate receptors (NMDARs) in cerebellar molecular layer interneurones (MLIs) are expressed and activated unusual ways: at parallel fibre synapses they only recruited by repetitive stimuli, suggesting an extrasynaptic location, whereas their activation climbing is purely mediated spillover. NMDARs thought to play important role plasticity different levels of the circuitry. Evaluation functional properties physiological roles will be facilitated knowledge NMDAR isoforms...
In 131 patients treated exclusively by selective denervation during the past 10 years, all or almost abnormal movements of spasmodic torticollis were suppressed in 115 (88%) while preserving posture and mobility. This approach was also used certain forms adult-onset dystonia. An appreciable amount remained other patients, either due to residual innervation because limitation necessary preserve normal (laterocollis) neck stability (retrocollis). A medio-lateral posterior cervical region...