A5033674142- Carcinogens and Genotoxicity Assessment
- Neurogenesis and neuroplasticity mechanisms
- Laser Applications in Dentistry and Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Stress Responses and Cortisol
- Glycosylation and Glycoproteins Research
- Epilepsy research and treatment
- Multiple Sclerosis Research Studies
- Neuroendocrine regulation and behavior
- Spinal Cord Injury Research
- Molecular Biology Techniques and Applications
- TGF-β signaling in diseases
- Barrier Structure and Function Studies
- Cancer Cells and Metastasis
- Health, Environment, Cognitive Aging
- Effects of Radiation Exposure
- dental development and anomalies
- Redox biology and oxidative stress
- Delphi Technique in Research
- Nitric Oxide and Endothelin Effects
- Effects and risks of endocrine disrupting chemicals
- Spaceflight effects on biology
Universidade Federal de São Paulo
2011-2023
Brazilian Biosciences National Laboratory
2023
Wellcome/MRC Cambridge Stem Cell Institute
2012-2015
University of Cambridge
2012-2015
Universidade Estadual de Campinas (UNICAMP)
2001-2006
The Sox family of transcription factors have been widely studied in the context oligodendrocyte development. However, comparatively little is known about role Sox2, especially during CNS remyelination. Here we show that expression Sox2 occurs progenitor cells (OPCs) rodent models myelination and activated adult OPCs responding to demyelination, also detected multiple sclerosis lesions. In normal white matter both mice rats, it neither expressed by nor oligodendrocytes (although a...
The maintenance of blood-brain barrier (BBB) integrity is essential for providing a suitable environment nervous tissue function. BBB disruption involved in many central system diseases, including epilepsy. Evidence demonstrates that breakdown may induce epileptic seizures, and conversely, seizure-induced cause further episodes. This study was conducted based on the premise impairment brain during triggering event determine organization functioning epileptogenesis, have key role this...
Protein tyrosine phosphatase receptor type Z (Ptprz) is widely expressed in the mammalian central nervous system and has been suggested to regulate oligodendrocyte survival differentiation. We investigated role of Ptprz remyelination after acute, toxin-induced demyelination null mice. found neither obvious impairment recruitment precursor cells, astrocytes, or reactive microglia/macrophage lesions nor a failure for cells differentiate remyelinate axons at lesions. However, we observed an...
It is known that chronic high levels of corticosterone (CORT) enhance aversive responses such as avoidance and contextual freezing. In contrast, CORT does not alter defensive behavior induced by the exposure to a predator odor. Since different defense-related have been associated with specific anxiety disorders found in clinical settings, observation alters some behaviors but others might be relevant understanding neurobiology anxiety. present study, we investigated effects administration...
Insulin-dependent diabetes mellitus is caused by autoimmune destruction of pancreatic beta cells. Non-obese diabetic (NOD) mice spontaneously develop similar to the human disease. Cytokines produced islet-infiltrating mononuclear cells may be directly cytotoxic and can involved in islet coordinated CD4+ CD8+ We utilized a semiquantitative RT-PCR assay analyze vitro mRNA expression TNF-alpha IFN-gamma cytokine genes isolated islets (N = 100) spleen (5 x 10(5) cells) from female NOD during...
Immunity to mycobacterial antigens may contribute the maintenance of self-tolerance. Exposure immune system antigen might well stimulate exert control over unwanted self-reactive clones. We demonstrated that in vivo administration Mycobacterium tuberculosis, PPD, and PPD peptide (180–196) prior immunization with Myelin Basic Protein (MBP)led a moderate increase γδ T cells, suppression response, reduction severity Experimental Autoimmune Encephalomyelitis. The immunosuppression observed is...
The aim of this study was to evaluate the effectiveness 3 different fluences low-level laser therapy (LLLT) in intermediate period spinal cord repair using an experimental model rats. Thirty two rats were randomly divided into four groups: Control Group (CG); Laser treated group 500 J/cm² (L-500); 750 (L-750) and 1000 (L-1000). Spinal injury (SCI) performed by impactor equipment (between 9th 10th thoracic vertebrae), with a pressure 150 kdyn. Afterwards, injured region irradiated daily for...