A5101642481- Cerebral Palsy and Movement Disorders
- Coronary Interventions and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Neurogenetic and Muscular Disorders Research
- Cardiovascular Disease and Adiposity
- Anesthesia and Neurotoxicity Research
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Tissue Engineering and Regenerative Medicine
- Intensive Care Unit Cognitive Disorders
- Metabolism and Genetic Disorders
- Anesthesia and Sedative Agents
- Sirtuins and Resveratrol in Medicine
- Neonatal and fetal brain pathology
- Cardiac tumors and thrombi
- Air Quality and Health Impacts
- Genomics and Rare Diseases
- Ginseng Biological Effects and Applications
- Cardiac Imaging and Diagnostics
- Pluripotent Stem Cells Research
- Heparin-Induced Thrombocytopenia and Thrombosis
Jiangsu Province Hospital
2024
Zhengzhou Children's Hospital
2021-2024
Zhengzhou University
2021-2024
Air Force Medical University
2016-2023
Xijing Hospital
2016-2023
Radboud University Medical Center
2019-2022
Ollscoil na Gaillimhe – University of Galway
2020-2022
Radboud University Nijmegen
2019-2022
Third People's Hospital of Yunnan Province
2020
Beihang University
2020
Importance Prior trials of extracranial-intracranial (EC-IC) bypass surgery showed no benefit for stroke prevention in patients with atherosclerotic occlusion the internal carotid artery (ICA) or middle cerebral (MCA), but there have been subsequent improvements surgical techniques and patient selection. Objective To evaluate EC-IC symptomatic ICA MCA, using refined operator Design, Setting, Participants This was a randomized, open-label, outcome assessor–blinded trial conducted at 13...
The optimal antiplatelet strategy in the second year after percutaneous coronary intervention (PCI) remains unclear.We aimed to compare ticagrelor monotherapy with aspirin on clinical outcomes beyond 1 post-PCI.This post hoc subanalysis of open-label, all-comers, randomised GLOBAL LEADERS trial, which compared 23-month following 1-month dual therapy (DAPT) 12-month DAPT, only included patients who, at 12 months, were free from ischaemic and bleeding events adherent their assigned therapy....
Downregulation of adiponectin (APN) multimerization is significantly correlated with the aggravation myocardial ischemia/reperfusion (MI/R) injury in type 2 diabetes mellitus (T2DM). Resveratrol (RSV) upregulates APN adipocytes, but whether RSV improves endogenous and thus attenuates MI/R T2DM mice has never been investigated. were treated 10 mg/kg daily for 3 weeks, followed by 30 minutes ischemia hours or 24 reperfusion. administration alleviated diabetic mice, as evidenced reduced infarct...
Abstract Mechanical stimulation is an important factor regulating mesenchymal stem cell (MSC) functions such as proliferation. The Ca 2+ ‐activated K + channel, 3.1, critically engaged in MSC proliferation but its role mechanical regulation of remains unknown. Here, we examined the 3.1 channel expression and rat bone marrow‐derived (BMSC) response to stretch. Application stretch stimulated BMSC via promoting cycle progression. Such up‐regulated pharmacological or genetic inhibition strongly...
Time-to-first-event analysis considers only the first event irrespective of its severity. There are several methods to assess trial outcomes beyond time-to-first-event analysis, such as analyzing total events and ranking outcomes. In GLOBAL LEADERS study, did not show superiority ticagrelor monotherapy following one-month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention conventional 12-month DAPT followed by aspirin in reduction primary composite end point all-cause...
Ischemic post-conditioning (IPO) activates Akt signaling to confer cardioprotection. The responsiveness of diabetic hearts IPO is impaired. We hypothesized that decreased cardiac SIRT1, a positive regulator Akt, may be responsible for the impaired IPO-mediated High-fat diet and streptozotocin-induced mice were subjected myocardial ischemia/reperfusion (MI/R, 30 min ischemia 180 reperfusion) or (three cycles 10 s reperfusion at onset reperfusion). Adenoviral vectors encoding GFP SIRT1...
Abstract Ischemia/reperfusion (I/R) injury accounts to be a prime cause of neurological deficit following stroke. This study aimed explore the neuro‐protective effects Xanthoangelol (XAG) on I/R‐induced in both vivo and vitro models. Our data demonstrated that XAG can shrink infarct size brain edema middle cerebral artery occlusion (MCAO) model. In addition, was capable alleviating rats have undergone MCAO procedure. Meanwhile, antiapoptotic activities against neuronal were evidenced further...
The efficacy and safety of continued bivalirudin infusion after percutaneous coronary intervention (PCI) remains uncertain. We sought to investigate the association between post-PCI risk net adverse clinical events (NACE) at 30 days.In GLOBAL LEADERS study, all patients who received during PCI were categorized according use procedure. primary endpoint present analysis was NACE [a composite all-cause death, any stroke, myocardial infarction, revascularization, bleeding assessed Bleeding...
Abstract Background Exposure to secondhand smoke (SHS) during pregnancy can cause complications and adverse birth outcomes. About 40% of Chinese expectant fathers are smokers they rarely attempt quit smoking. There is a paucity effective smoking cessation services targeting this population. In study, we assessed the behavior examined its association with abstinence after their partner became pregnant, which an essential prerequisite for designing interventions. Methods We conducted...
Cerebral palsy (CP) is a disease with high disability rate and morbidity. The clinical symptoms of cerebral are motor dysfunction abnormal posture development, often accompanied by cognitive impairment. Massage, traditional Chinese Medicine therapy, can coordinate Zang Fu, regulate Qi blood, make the viscera work more smoothly, calm Yin Yang. Furthermore, it has been an effective method for CP in clinical. This paper summarizes set simple standardized manipulations massage young rats CP,...
Background & Objectives: Amnesia is the absence of recall. Benzodiazepines greatly impair ability to learn new information, a condition known as anterograde amnesia. An inappropriate dose midazolam will fail produce amnesia or may cause side effects such respiratory depression and delayed emergence from anesthesia. It clinical importance observe determine effective dose, maintenance time, factors that can influence intravenous midazolam-induced Materials Methods: Trial One: Forty-nine ASA...
Background: Cerebral palsy (CP) is the most common motor disability of children with substantial heritability, yet extent its genetic etiology not fully appreciated.Methods: Exome sequencing (ES) copy number variant (CNV) calling was performed on 1536 CP and genome (GS) 42 (mean age 24·5 months, range 5 to 216 months). Genetic interpretation 2293 known neurodevelopmental disorder (NDD) genes followed American College Medical Genetics Genomics/Association for Molecular Pathology (ACMG/AMP)...
Abstract Background and Aim Intramyocardial injection of alginate-hydrogel, an emerging promising strategy for patients with advanced heart failure (HF), is limited by the paucity commercially available intramyocardial delivery methods. This study investigates feasibility safety a novel X-DROP catheter system (Figure 1) alginate-hydrogel to pre-defined target areas in treatment HF reduced ejection fraction. Methods results Prior First-in-man, we demonstrated that transcatheter...