A5014159462- Intracerebral and Subarachnoid Hemorrhage Research
- Balance, Gait, and Falls Prevention
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Soil Carbon and Nitrogen Dynamics
- Atrial Fibrillation Management and Outcomes
- Wound Healing and Treatments
- Rangeland Management and Livestock Ecology
- Cardiovascular and exercise physiology
- Non-Invasive Vital Sign Monitoring
- Physical Activity and Health
- Intracranial Aneurysms: Treatment and Complications
- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Gait Recognition and Analysis
- Genomic variations and chromosomal abnormalities
- Neurological Complications and Syndromes
- Diabetic Foot Ulcer Assessment and Management
- Spinal Hematomas and Complications
- Cerebral Palsy and Movement Disorders
- Analog and Mixed-Signal Circuit Design
- Neuroscience and Neuropharmacology Research
- Moyamoya disease diagnosis and treatment
First Affiliated Hospital of Kunming Medical University
2017-2025
Kunming Medical University
2017-2025
Gansu Agricultural University
2022-2024
Pfizer (United States)
2019-2024
Tufts Medical Center
2017-2024
Pfizer (United Kingdom)
2024
Sichuan Tourism University
2024
Tufts University
2016-2021
Chongqing University of Posts and Telecommunications
2019
Columbia University
2017
Many clinical trials focus on restricting hematoma expansion following acute intracerebral hemorrhage (ICH), but selecting those patients at highest risk of is challenging.To develop a prediction score for in with primary ICH.Prospective cohort study 2 urban academic medical centers among having ICH available baseline and follow-up computed tomography volumetric analysis (817 the development 195 independent validation cohort).Hematoma was assessed using semiautomated software defined as more...
Technological advances in multimodal wearable and connected devices have enabled the measurement of human movement physiology naturalistic settings. The ability to collect continuous activity monitoring data with digital real-world environments has opened unprecedented opportunity establish clinical phenotypes across diseases. Many traditional assessments physical function utilized trials are limited because they episodic, therefore, cannot capture day-to-day temporal fluctuations...
Foxtail millet (Setaria italica) provides food and fodder in semi-arid regions infertile land. Resequencing of 184 foxtail recombinant inbred lines (RILs) was carried out to aid essential research on improvement. A total 483 414 single nucleotide polymorphisms were determined. Bin maps constructed based the RILs' recombination data. Based high-density bin map, we updated Zhanggu reference with 416 Mb after adding 16 unanchored scaffolds Yugu some assembly error correction 3158 gaps filled....
Abstract Globally, the infection rate of carbapenem-resistant Klebsiella pneumoniae (CRKP) producing OXA-48-like carbapenemase is increasing, posing a significant public health threat due to its high antibiotic resistance. Between December 2019 and April 2023, ten CRKP strains carrying were isolated from inpatients at First Affiliated Hospital Kunming Medical University. Wholegenome sequencing (WGS) revealed that all carried OXA-232 gene, variant OXA-48-like, located on non-conjugative...
Digital health technologies (DHTs) can collect gait and physical activity in adults, but limited studies have validated these children. This study compared metrics collected using DHTs to those by reference comparators during in-clinic sessions, a normative accelerometry dataset, evaluate participants' comfort their compliance wearing the at-home.
Land use change can significantly alter the proportion of soil aggregates, thereby influencing aggregate stability and distribution organic carbon (SOC). However, there is minimal research on variations in stability, SOC aggregates following land from farmland (FL) to forest grassland Loess Plateau region China. Select six patterns (farmland (FL), abandoned cropland (ACL), Medicago sativa (MS), natural (NG), Picea asperata Mast. (PA), Platycladus orientalis (L.) Franco (PO)) China collect...
The use of digital health products has gained considerable interest as a new way to improve therapeutic research and development. Although these are being adopted by various industries stakeholders, their incorporation in clinical trials been slow due disconnect between the promises potential risks using technologies absence regulatory support. Foundation for National Institutes Health (FNIH) Biomarkers Consortium hosted public workshop address challenges opportunities this field. Important...
The ability to perform sit-to-stand (STS) transfers has a significant impact on the functional mobility of an individual. Wearable technology potential enable objective, long-term monitoring STS during daily life. However, despite several recent efforts, most algorithms for detecting rely multiple sensing modalities or device locations and have predominantly been used assessment performance prescribed tasks in lab setting. A novel wavelet-based algorithm from data recorded using...
Lung cancer in Xuanwei (LCXW), China, is known throughout the world for its distinctive characteristics, but little about pathogenesis. The purpose of this study was to screen potential novel "driver genes" LCXW.Genome-wide DNA copy number alterations (CNAs) were detected by array-based comparative genomic hybridization and differentially expressed genes (DEGs) gene expression microarrays 8 paired LCXW non-cancerous lung tissues. Candidate driver screened integrated analysis CNAs DEGs....
Cerebrovascular anomalies such as aneurysms and arteriovenous malformations (AVMs) are rare but important causes of intracerebral hemorrhage (ICH) associated with a significantly higher risk rebleeding; early detection treatment crucial.
<h3>Objective:</h3> To compare comorbidities and use of surgery palliative care between men women with intracerebral hemorrhage (ICH). <h3>Methods:</h3> The Ethnic/Racial Variations Intracerebral Hemorrhage (ERICH) study is a prospective, multicenter, case-control ICH risk factors outcomes. We compared comorbidities, treatments, do-not-resuscitate (DNR) orders in vs women. Multivariate analysis was used to assess the likelihood after adjustment for variables that were <i>p</i> < 0.1...
Abstract Digital health technologies (DHTs) are increasingly being adopted in clinical trials, as they enable objective evaluations of parameters free-living environments. Although lumbar accelerometers notably provide reliable gait parameters, embedding chest devices, already used for vital signs monitoring, could capture a more comprehensive picture participants’ wellbeing, while reducing the burden multiple devices. Here we assess validity measured from accelerometer. Twenty healthy...
Traditional measurement systems utilized in clinical trials are limited because they episodic and thus cannot capture the day-to-day fluctuations longitudinal changes that frequently affect patients across different therapeutic areas.The aim of this study was to collect evaluate data from multiple devices, including wearable sensors, compare them standard lab-based instruments domains daily tasks.Healthy volunteers aged 18-65 years were recruited for a 1-h assess sensors. They performed...
Background . Xuanwei City in Yunnan province has been one of the towns with highest lung cancer mortality China. The high content amorphous silica bituminous coal from is mainly present as irregular and spherical nanoparticles (SiNPs). It reported that correlated incidence Xuanwei. To explore role mechanism SiNPs tumorigenesis Xuanwei, human mononuclear cells (THP-1) bronchial epithelial (BEAS-2B) were cocultured a transwell chamber. Combined Benzo[ ]pyrene-7, 8-dihydrodiol-9, 10-epoxide...
<h3>Objective:</h3> To assess the validity of gait speed derived using a sternum-worn accelerometer, thus supporting deployment single device to measure multiple biosignals, e.g., and ECG. <h3>Background:</h3> Gait assessment is essential understand, diagnose, monitor numerous neurological disorders. In contrast conventional clinical evaluations, wearable sensors used in free-living environments grant more objective measurements. While wearing widespread lumbar-worn accelerometers may be...
Genetic factors have been found to be associated with the efficacy and adverse reactions of antiseizure medications. BCL11A is an important regulator development neuronal networks. However, role in epilepsy remains unclear. This study aimed evaluate genetic association susceptibility develop epileptic seizures therapeutic response patients Han Chinese. We matched 450 cases 550 healthy controls 131 drug-resistant 319 drug-responsive from two different centers. analysis, interaction expression...
Abstract Background Recombinant factor VIIa (rFVIIa) may be used for rapid hemostasis in life-threatening hemorrhage. In warfarin-associated intracerebral hemorrhage (wICH), FVIIa use is controversial and carry significant thromboembolic risks. We compared incidence of baseline risk factors thromboembolism rates wICH patients treated with additional rFVIIa to those standard therapy fresh frozen plasma (FFP) vitamin K alone. Methods identified 45 consecutive over 5-year period, 34 alone as...