A5000772564- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Muscle metabolism and nutrition
- Cardiovascular Function and Risk Factors
- Pharmacology and Obesity Treatment
- Fatty Acid Research and Health
- Cholesterol and Lipid Metabolism
- Diet and metabolism studies
- Mosquito-borne diseases and control
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Cardiovascular and exercise physiology
- Peroxisome Proliferator-Activated Receptors
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Disease and Adiposity
- Inflammatory mediators and NSAID effects
- Antioxidant Activity and Oxidative Stress
- Viral Infections and Vectors
- RNA and protein synthesis mechanisms
Umeå University
1974-2024
Vanderbilt University Medical Center
2024
Karolinska University Hospital
1976-2018
Karolinska Institutet
1994-2018
University of California, Berkeley
2014-2018
QB3
2014-2018
Berkeley College
2018
Hammersmith Hospital
2018
Max Planck Institute of Biochemistry
2008-2014
National Institutes of Health
2010-2012
Adjusted-dose warfarin is highly efficacious for prevention of ischaemic stroke in patients with atrial fibrillation (AF). However, this treatment carries a risk bleeding and the need frequent medical monitoring. We sought an alternative that would be safer easier to administer AF who are at high-risk thromboembolism.1044 least one thromboembolic factor (congestive heart failure or left ventricular fractional shortening < = 25%, previous thromboembolism, systolic blood pressure more than 160...
ABSTRACT. Consecutive survivors of a myocardial infarction from the Southern Hospital, below 70 years age, were randomized into Control group ( n =276) and Treatment =279). The latter was openly prescribed combination clofibrate nicotinic acid for serum lipid lowering. Each patient should remain in study 5 be seen regularly every 4 months at special IHD outpatient clinic within hospital. concentration cholesterol triglyceride lowered by 13% 19%, respectively, compared to group. Total...
Abstract Carlson LA, Hamsten A, Asplund A (King Gustaf V Research Institute and Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden). Pronounced lowering serum levels lipoprotein Lp(a) in hyperlipidaemic subjects treated with nicotinic acid. Thirty‐one consecutive unselected patients were daily 4 g acid for 6 weeks. The concentrations Lp(a), the major classes, determined before after treatment. Nicotinic significantly reduced whole patient group. Linear regression...
Membrane scission by ESCRTs The ESCRT protein complexes are essential for cell division, the release of HIV from infected cells via budding, and other processes involving narrow membrane necks their inner surface. unusual inside-directed cutting has made it hard to recapitulate this reaction understand its mechanism. Schöneberg et al. encapsulated inside lipid vesicles used optical tweezers pull out nanotubes. In presence adenosine triphosphate, clusters generated force constricted nanotube,...
The relations of high density lipoprotein (HDL) subclasses to severity and rate progression coronary atherosclerosis were investigated in 60 men who had survived a myocardial infarction before the age 45 years subsequently undergone two angiographies, with an intervening time interval 4-7 between angiographies. Five HDL different particle sizes determined by gradient gel electrophoresis, major serum classes separated preparative ultracentrifugation connection second angiography. Highly...
The metabolism of chylomicron remnants and VLDL was studied in healthy controls normo- (NTG) hypertriglyceridemic (HTG) patients with coronary artery disease after intake an oral fat load. Specific determination apo B-48 B-100 enabled separation the respective contribution two lipoprotein species. postprandial plasma levels small (Sf 20-60) large 60-400) increased NTG patients. In contrast, only HTG An increase seen response to load all groups, whereas were either unchanged patients, or...
Background —Apolipoprotein (apo) A-I is the major protein component of HDL, a cholesterol transport particle that protects against atherosclerosis. Apo believed to promote reverse transport, transferring from peripheral cells liver for subsequent elimination. To test this hypothesis in humans, we measured fecal steroid excretion before and after intravenous infusion human proapo (precursor apo A-I) liposome complexes. Methods Results —Four subjects with heterozygous familial...
ABSTRACT A 14‐year follow‐up of the Stockholm prospective study is reported. number 130 new myocardial infarctions (MI) were found in a group men ( n = 3189) and another 46, i.e. total 176 MI, =3 486). Different types multivariate statistical analyses show that age, blood pressure, smoking, fasting plasma concentrations cholesterol triglycerides, ESR Hb independent risk factors for while weight/height index was not. Elevated BP became an important factor only after age 50. When BP, smoking...
Palmitate-9, 10-H 3 has been infused intravenously at a constant rate together with various C 14 -labeled fatty acids in healthy subjects rest and during exercise. No significant differences the rates of fractional turnover were found between H palmitate or oleate. Retention considerably larger fraction linoleate blood plasma precluded accurate assessment its rate. The oxidation palmitate-I-C , palmitate-U-C oleate-I-C linoleate-I-C exercise similar. relative abundance palmitate, oleate,...
Abstract Prostaglandins E 1 , 2 3 and F 1α (PGE etc) were given intravenously to anesthetized dogs during continuous infusion of norepinephrine. PGE in doses 5 micrograms all significantly reduced the arterial concentration free fatty acids plasma (FFA) blood pressure, while same dose PGF had no significant effect. Continuous intraarterial infusions norepinephrine a more pronounced effect on FFA pressure than intravenous infusions. Infusion almost completely blocked usual increase caused by...
In this 19-year follow-up of the Stockholm Prospective Study (SPS), 321 male and 55 female deaths from myocardial infarction (MI) had occurred. Fasting levels plasma triglycerides acted as an independent risk factor for cause death in both sexes, which was primary question asked when SPS designed. Other factors MI were men women age, systolic blood pressure, smoking only, cholesterol, haemoglobin erythrocyte sedimentation rate.
Abstract The kinetics of the elimination from blood stream intravenously injected fat emulsion (Intralipid®) and chylo‐micrones have been studied in fasting dog. was estimated by determination arterial whole glyceride concentration subtraction basal concentration. same type found all dogs studied. consisted two phases operating above below a around 1.1 mM (increase level) respectively. Above linear, i.e. constant amount glycerides eliminated per unit time. mean value for this phase 0.05...