A5101443047- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Retinal and Macular Surgery
- Connexins and lens biology
- Wound Healing and Treatments
- Anorectal Disease Treatments and Outcomes
- Traumatic Ocular and Foreign Body Injuries
- Ocular Infections and Treatments
- Ocular Oncology and Treatments
- Skin and Cellular Biology Research
- Connective tissue disorders research
- Orthopaedic implants and arthroplasty
- Inflammatory mediators and NSAID effects
- Surgical Sutures and Adhesives
- Hedgehog Signaling Pathway Studies
- Cell Adhesion Molecules Research
- TGF-β signaling in diseases
- Bone and Dental Protein Studies
- Protease and Inhibitor Mechanisms
- Retinal Diseases and Treatments
- Vascular Malformations Diagnosis and Treatment
- Ocular and Laser Science Research
Kumamoto University
2020-2025
Tokushima Red Cross Hospital
2024
Kumamoto University Hospital
2020-2023
Wakayama Medical University
2007-2017
Kihoku hospital
2001-2017
Ministry of Education, Culture, Sports, Science and Technology
2014
Numazu City Hospital
2011
Kajima Corporation (Japan)
2011
Chiba University
2011
Kawasaki Medical School
2006-2011
The purpose of the present study was to examine roles signaling pathways potentially activated by TGFbeta (i.e., Smad and p38 mitogen-activated kinase [MAPK]) in regulation cell migration proliferation healing mouse corneal epithelium.Activation Smads or p38MAPK evaluated immunohistochemistry epithelium after debridement. role endogenous epithelial determined organ-cultured corneas with an defect, presence absence a TGFbeta-neutralizing antibody inhibitors, respectively. Cell incorporation...
To elucidate Japanese trends for perioperative disinfection and antibiotic selection during cataract surgeries.Perioperative iodine use prophylaxis surgery were surveyed in eight regions Japan by mail or through interviews from February 1 to March 1, 2014.We 572 surgeons, of whom 386 (67%) responded. Most the surgeons (94%) used compounds before periocular skin (povidone-iodine [PI]: 79%; polyvinyl alcohol-iodine [PAI]: 15%) conjunctival (85%; PI: 36%; PAI: 49%). Preoperative was primarily...
To examine the role of tumor necrosis factor alpha (TNFalpha) in stromal neovascularization injured cornea vivo and cytokine-enhanced vessel-like endothelial cell tube formation vitro.An vitro model angiogenesis was used to roles TNFalpha on by human umbilical vein cells (HUVECs) cocultured with fibroblasts induction transforming growth beta1 (TGFbeta1) vascular (VEGF). Central cauterization induce corneas wild-type (WT) TNFalpha-null (Tnfalpha(-/-)) mice. At 7, 14, or 21 days injury,...
To compare the wound-healing process in rabbit cornea after photorefractive keratectomy (PRK) and laser situ keratomileusis (LASIK) with same refractive correction.Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan.Adult albino rabbits (N = 24) were used. One eye each animal had PRK or LASIK correction. Each was killed an interval up to 6 months. The expression pattern corneal stromal injury-related molecules 2 treatments compared. Paraffin sections processed...
A single layer of corneal endothelial cells covers the posterior surface Descemet membrane. Normally, do not proliferate, suggesting that factors inhibit their undergoing mitosis. Fibroblastic transformation due to syphilitic interstitial keratitis or alkali burn may result in stromal opacification. Various growth such as fibroblast factor 2 and transforming β are involved "endothelial-mesenchymal transition (EnMT)." Endothelial wound-healing assay experiments revealed cell migration toward...
To investigate the effects of loss osteopontin (OPN) in development neovascularization corneal stroma mice. Cell culture study was also conducted to clarify OPN transforming growth factor (TGF) beta1-driven cell signaling and expression vascular endothelial (VEGF).Ocular fibroblasts from wild-type OPN-null mice were used role TGFbeta1 signal VEGF expression. The effect absence on evaluated mice.In ocular fibroblast culture, attenuated signals (Smad3 p38) reduced VEGF. Loss mice.OPN is...
We located immunohistochemically the matrix metalloproteinases (MMP) -1, -2, -3 and -9 tissue inhibitors of (TIMP) -1 -2 in fibrous capsule patients with intraocular lenses (IOLs).During vitreoretinal surgery 10 we obtained post-cataract lens capsules or without an IOL. The mean interval between previous cataract operation extraction specimens was 35.2 months (range: 2-120 months). Circular sections anterior epithelial cells (LECs) were also during surgery. Specimens processed for...
To evaluate the biocompatibility of various materials including a poly(2-hydroxyethyl methacrylate [HEMA])/(6-hydroxyhexyl [HOHEXMA]) hydrophilic hydrogel intraocular lens (IOL) (Hydroview, Bausch & Lomb). Department Ophthalmology, Wakayama Medical University, Wakayama, Japan. Ten opacified anterior capsules were extracted, 3 specimens with Hydroview IOL. They processed for light and electron microscopy. Immunohistochemistry alpha-smooth muscle actin (alpha SMA) collagen types was also done...
To examine the histology of preserved anterior lens capsule in vitrectomised and lensectomised rabbit eyes with without silicone oil tamponade.Forty adult Japanese albino rabbits received two port vitrectomy lensectomy or tamponade one eye under both general topical anaesthesia. Anterior was during operation. After healing intervals residual histologically observed light electron microscopy.Immediately after operation, cuboidal epithelial cells were on posterior surface capsule. During...
Contamination of the conjunctiva in association with nasolacrimal duct obstruction is by all accounts a risk factor for infectious endophthalmitis post-cataract surgery. All patients who underwent cataract day surgery routinely received syringing normal saline at Wakayama Medical University Hospital, Japan, from 2011 to 2013. The microorganisms isolated conjunctival swab samples occluded ducts and their susceptibility antibiotics, as well operation outcomes were retrospectively investigated....