A5091616121- Systemic Sclerosis and Related Diseases
- Vascular Tumors and Angiosarcomas
- Dermatologic Treatments and Research
- Cancer and Skin Lesions
- Sarcoma Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Cardiac tumors and thrombi
- Immunotherapy and Immune Responses
- Dermatological and Skeletal Disorders
- Nonmelanoma Skin Cancer Studies
- Inflammatory Myopathies and Dermatomyositis
- Psoriasis: Treatment and Pathogenesis
- Cancer Genomics and Diagnostics
- Skin and Cellular Biology Research
- Eosinophilic Disorders and Syndromes
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Melanoma and MAPK Pathways
- Connective Tissue Growth Factor Research
- CAR-T cell therapy research
- Polyomavirus and related diseases
- Cutaneous Melanoma Detection and Management
- Skin Diseases and Diabetes
- Cutaneous lymphoproliferative disorders research
- Autoimmune and Inflammatory Disorders
Kumamoto University
2016-2025
Kumamoto University Hospital
2020-2024
Fundación Juan March
2021
Kumamoto City Hospital
2013
Among IL-17 families, IL-17A and IL-17F share amino acid sequence similarity bind to IL-17R type A. signaling is implicated in the pathogenesis of various autoimmune diseases, but its role regulatory mechanism extracellular matrix expression contribution phenotype systemic sclerosis (SSc) both remain be elucidated. This study revealed that was significantly increased involved skin sera SSc patients, whereas levels did not increase. In contrast, A fibroblasts decreased comparison with normal...
Abstract Systemic and localized scleroderma (SSc LSc) is characterized by excessive deposition of collagen tissue fibrosis in the skin. Although they have fundamental common characteristics including autoimmunity, little known about exact mechanism that mediates expression these disorders. In current study, we tried to evaluate possibility microRNAs (miRNAs) play some roles pathogenesis seen diseases. miRNA patterns were evaluated array analysis, real-time PCR, situ hybridization. The...
Abstract Previous reports indicated the significance of TGF-β signaling in pathogenesis systemic sclerosis. We tried to evaluate possibility that microRNAs (miRNAs) play a part type I collagen upregulation seen normal fibroblasts stimulated with exogenous and sclerosis (SSc) fibroblasts. miRNA expression profile was evaluated by PCR array real-time PCR. The protein determined immunoblotting. In vivo detection paraffin section performed situ hybridization. Several miRNAs were found be...
Aberrant immune responses to viral pathogens contribute pathogenesis, but our understanding of pathological caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019...
Objectives. microRNAs (miRNAs) play a part in various cellular activities. However, the role of miRNA SSc is not fully understood. This study investigated expression and miR-92a patients evaluated possibility that involved pathogenesis this disease. Methods. Serum samples were obtained from 61 patients. mRNAs purified serum levels miR-135 measured with quantitative real-time PCR. dermal fibroblasts was also determined by Immunoblotting performed to detect MMP-1 protein. Results. The median...
Recently, increased evidence has shown that serum micro (mi)RNA levels are a useful biomarker for the diagnosis, prognosis and therapeutic value of various diseases. However, miRNA not been investigated in patients with systemic sclerosis (SSc), to our knowledge.To investigate possibility Homo sapiens miR-142 stem-loop (hsa-miR-142-3p), one miRNAs regulating expression integrin αV, could be specific disease marker SSc.Serum samples were obtained from 61 SSc 20 healthy controls. Patients...
In this study, we investigated whether circulating S100A7 and S100A15 DNA copies in cell-free (cfDNA) are elevated patients with psoriasis atopic dermatitis (AD) their levels correlated clinical findings. Serum cfDNA was obtained from 124 45 AD patients. Circulating were significantly higher than healthy controls. Although showed a significant positive correlation the Psoriasis Severity Area Index (PASI) scores severe (PASI ≥ 10), there no between disease severity. Furthermore, patients,...
Angiosarcoma is a malignant vascular tumor originating from endothelial cells of blood vessels or lymphatic vessels. The specific driver mutations in angiosarcoma remain unknown. In this study, we investigated issue by transcriptome sequencing patient-derived (ISO-HAS), identifying novel fusion gene NUP160-SLC43A3 found to be expressed 9 25 human specimens that were examined. tumors harboring the gene, duration between onset symptoms and first hospital visit was significantly shorter,...
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Expression of microRNA (miRNA) in the skin dermatomyositis has not previously been studied detail. In this study, we performed miRNA array analysis using miRNAs purified from dermatomyositis-involved and normal skin, found that several were up- or down-regulated skin. Among them, focused on miR-7, one most Total serum, hsa-miR-7 levels measured with quantitative real-time PCR specific primer. Serum miR-7 significantly decreased patients compared subjects other autoimmune diseases. Thus,...
Localized scleroderma (LSc) exhibits fibrosis of the skin and subcutaneous tissue. LSc shows an excessive deposition type 1 collagen. To elucidate mechanism collagen overexpression in LSc, we investigated epigenetics, focusing on microRNA (miRNA). miRNA expression profile was determined by PCR array analysis. The microRNA-196a (miR-196a) tissue examined situ hybridization or real-time PCR. serum levels miR-196a were measured analysis demonstrated that level markedly decreased vivo....
To investigate the relationship between M2 macrophages and disease activity in SLE. The expression of CD163, an macrophage marker, skin specimens was evaluated by immunohistochemistry. Quantitative real-time polymerase chain reaction performed to determine mRNA CD163 section. Serum levels soluble were measured 20 SLE patients 12 healthy controls with specific enzyme-linked immunosorbent assays. number CD163-positive significantly increased. had higher serum sCD163 than controls. By analysis...
Dermatomyositis (DM) is characterized by skin manifestations accompanying and preceding muscle weakness. Gottron's papules, one of the manifestations, are great diagnostic value because they specific to DM. However, pathogenesis papules remains unclear. We investigated expression pattern miRNAs in DM patients evaluated possibility that play a role its pathogenesis. were extracted from tissues sera with DM, clinically amyopathic (CADM) healthy controls. To identify pathogenic miRNAs, we...