A5081425490- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Gastrointestinal motility and disorders
- Probiotics and Fermented Foods
- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- Immune Response and Inflammation
- Helicobacter pylori-related gastroenterology studies
- Immune cells in cancer
- Pregnancy and Medication Impact
- Mast cells and histamine
- Galectins and Cancer Biology
- Phagocytosis and Immune Regulation
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- Force Microscopy Techniques and Applications
- Immunotherapy and Immune Responses
- Escherichia coli research studies
- Oral microbiology and periodontitis research
- Cellular Mechanics and Interactions
- Bioactive Compounds and Antitumor Agents
- Oral health in cancer treatment
- Herbal Medicine Research Studies
Osaka University
2015-2024
Osaka International University
2012-2021
Japan Agency for Medical Research and Development
2016-2019
Immune Regulation (United Kingdom)
2016
Japan Science and Technology Agency
2012-2015
Specific intestinal microbiota has been shown to induce Foxp3+ regulatory T cell development. However, it remains unclear how development of another subset, Tr1 cells, is regulated in the intestine. Here, we analyzed role two probiotic strains bacteria, Lactobacillus casei and Bifidobacterium breve B. breve, but not L. casei, induced IL-10-producing cells that express cMaf, IL-21, Ahr large Intestinal CD103+ dendritic (DCs) mediated breve-induced cells. DCs from Il10−/−, Tlr2−/−, Myd88−/−...
Objectives Prevotella copri is considered to be a contributing factor in rheumatoid arthritis (RA). However, some non-Westernised countries, healthy individuals also harbour an abundance of P. the intestine. This study investigated pathogenicity RA patient-derived ( ) compared with control-derived HC ). Methods We obtained 13 P . strains from faeces patients and controls. Following whole genome sequencing, sequences were compared. To analyse arthritis-inducing ability , we examined two...
Foxp3+ regulatory T (Treg) cells, which suppress immune responses, are highly proliferative in vivo. However, it remains unclear how the active replication of Treg cells is maintained Here, we show that branched-chain amino acids (BCAAs), including isoleucine, required for maintenance state via acid transporter Slc3a2-dependent metabolic reprogramming. Mice fed BCAA-reduced diets showed decreased numbers with defective vivo capacity. lacking Slc3a2 specifically impaired and cells....
Abstract The bacterial species living in the gut mediate many aspects of biological processes such as nutrition and activation adaptive immunity. In addition, commensal fungi residing intestine also influence host health. Although interaction bacterium fungus has been shown, its precise mechanism during colonization human remains largely unknown. Here, we show between fungal for utilization dietary components driving their efficient growth intestine. Next generation sequencing fecal samples...
Adequate activation of CD4 + T lymphocytes is essential for host defense against invading pathogens; however, exaggerated activity effector cells induces tissue damage, leading to inflammatory disorders such as bowel diseases. Several unique subsets intestinal innate immune have been identified. However, the direct involvement cell in suppression T-cell-dependent inflammation poorly understood. Here, we report that CX 3 C chemokine receptor 1 high (CX CR1 ) CD11b CD11c are responsible...
In the intestine, mucin 2 (Muc2) forms a network structure and prevents bacterial invasion. Glycans are indispensable for Muc2 barrier function. Among various glycosylation patterns of Muc2, sialylation inhibits bacteria-dependent degradation. However, mechanisms by which creates degradation remain unknown. Here, focusing on two glycosyltransferases, St6 N-acetylgalactosaminide α-2,6-sialyltransferase 6 (St6galnac6) β-1,3-galactosyltransferase 5 (B3galt5), mediating generation desialylated...
Extracellular ATP is released from live cells in controlled conditions, as well dying inflammatory and, thereby, regulates T cell responses, including Th17 induction. The level of extracellular closely regulated by hydrolyzing enzymes, such ecto-nucleoside triphosphate diphosphohydrolases (ENTPDases). ENTPDase1/CD39, which expressed immune cells, was shown to regulate responses downregulating the level. In this study, we analyzed immunomodulatory function ENTPDase7, preferentially epithelial...
Research suggests that heart failure with reduced ejection fraction (HFrEF) is a state of systemic inflammation may be triggered by microbial products passing into the bloodstream through compromised intestinal barrier. However, whether microbiota exhibits dysbiosis in HFrEF patients largely unknown.Methods and Results:Twenty eight non-ischemic 19 healthy controls were assessed 16S rRNA analysis bacterial DNA extracted from stool samples. After processing sequencing data, bacteria...
Goblet cells play a protective role against GVHD after allogeneic stem cell transplantation in Lypd8-dependent manner.
Significance Following hemorrhage in damaged tissues, hemoglobin induces macrophages (Mϕs) possessing ability to protect against tissue inflammation. Hemorrhage-appearing mucosa is observed patients with inflammatory bowel disease. However, heme-mediated modulation of intestinal Mϕ activity remains poorly understood. Here, we provide evidence that Spi-C induced by heme a key molecule for providing noninflammatory gene expression patterns CX 3 CR1 high Mϕs. We found the Spic deficiency Mϕs...
Nanoparticles, i.e., particles with a diameter of ≤100 nm regardless their composing material, are added to various foods as moisturizers, coloring agents, and preservatives. Silicon dioxide (SiO2, silica) nanoparticles in particular widely used food additives. However, the influence SiO2 nanoparticle oral consumption on intestinal homeostasis remains unclear. The daily intake 10-nm-sized exacerbates dextran sulfate sodium (DSS)-induced colitis, whereas 30-nm-sized has no inflammation....
Inappropriate activation of the IL-23 signaling pathway causes chronic inflammation through induction immunopathological Th17 cells in several tissues including intestine, whereas adequate responses are essential for host defense against harmful organisms. In intestinal lamina propria, is primarily produced by innate myeloid dendritic (DCs) and macrophages (Mϕs). However, molecular mechanisms underlying regulation production these remains poorly understood. this study, we demonstrated that...
Significance Intestinal bacteria produce extracellular ATP in the lumen during their growth, which drives host immune responses. To avoid excessive reactions intestinal mucosa, luminal is finely tuned. However, how concentration of controlled colon remains poorly understood. Here, we discovered that ATP-hydrolyzing enzyme E-NTPD8 acts as an immunomodulator colon. Entpd8 deficiency led to high sensitivity DSS-induced colitis mice, was due sustained survival colonic neutrophils. Extracellular...
Wilms' tumor 1 (WT1) is a promising tumor-associated antigen for cancer immunotherapy. We developed an oral protein vaccine platform composed of WT1-anchored, genetically engineered Bifidobacterium longum (B. longum) and conducted in vivo study mice to examine its anticancer activity. Mice were orally treated with phosphate-buffered saline, wild-type B. longum105-A, 2012 displaying only galacto-N-biose/lacto-N-biose I-binding (GLBP), WT1 protein- GLBP-expressing 420. Tumor size reduced...