Chenghua Shao
A5048277979- Enzyme Structure and Function
- Protein Structure and Dynamics
- Computational Drug Discovery Methods
- Genetics, Bioinformatics, and Biomedical Research
- Bioinformatics and Genomic Networks
- Advanced Proteomics Techniques and Applications
- Advanced Electron Microscopy Techniques and Applications
- Machine Learning in Materials Science
- Genomics and Phylogenetic Studies
- Protein Kinase Regulation and GTPase Signaling
- Mass Spectrometry Techniques and Applications
- RNA and protein synthesis mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Crystallization and Solubility Studies
- Scientific Computing and Data Management
- Microbial Natural Products and Biosynthesis
- S100 Proteins and Annexins
- Gene expression and cancer classification
- Protease and Inhibitor Mechanisms
- Bone Tissue Engineering Materials
- Glycosylation and Glycoproteins Research
- Erythrocyte Function and Pathophysiology
- Cellular transport and secretion
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
Rutgers, The State University of New Jersey
2016-2025
Rutgers Sexual and Reproductive Health and Rights
2025
Worldwide Protein Data Bank
2020-2022
San Diego Supercomputer Center
2019
University of California, San Diego
2013-2019
European Bioinformatics Institute
2014
Wellcome Trust
2014
Donghua University
2013-2014
University of Montana
2013
Nanjing Tech University
2010
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), the US data center global PDB archive and a founding member of Worldwide partnership, serves tens thousands depositors in Americas Oceania makes 3D macromolecular structure available at no charge without restrictions to millions RCSB.org users around world, including >660 000 educators, students members curious public using PDB101.RCSB.org. include structural biologists crystallography,...
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB, rcsb.org), the US data center global PDB archive, serves thousands of Depositors in Americas and Oceania makes 3D macromolecular structure available at no charge without usage restrictions to more than 1 million rcsb.org Users worldwide 600 000 pdb101.rcsb.org education-focused around globe. include structural biologists using crystallography, nuclear magnetic resonance spectroscopy electron microscopy....
The Protein Data Bank (PDB) is the single global archive of experimentally determined three-dimensional (3D) structure data biological macromolecules. Since 2003, PDB has been managed by Worldwide (wwPDB; wwpdb.org), an international consortium that collaboratively oversees deposition, validation, biocuration, and open access dissemination 3D macromolecular data. Core Archive houses atomic coordinates more than 144 000 structural models proteins, DNA/RNA, their complexes with metals small...
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB, http://rcsb.org), the US data center global PDB archive, makes freely available to all users, from structural biologists computational and beyond. New tools resources have been added RCSB web portal in support of a 'Structural View Biology.' Recent developments improved User experience, including high-speed NGL Viewer that provides 3D molecular visualization any browser, file download enhanced organization...
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), founding member of the Worldwide (wwPDB), is US data center open-access PDB archive. As wwPDB-designated Archive Keeper, RCSB also responsible security. Annually, serves >10 000 depositors three-dimensional (3D) biostructures working on all permanently inhabited continents. delivers from its research-focused RCSB.org web portal to many millions consumers based in virtually every United Nations-recognized...
Abstract Analyses of publicly available structural data reveal interesting insights into the impact three‐dimensional (3D) structures protein targets important for discovery new drugs (e.g., G‐protein‐coupled receptors, voltage‐gated ion channels, ligand‐gated transporters, and E3 ubiquitin ligases). The Protein Data Bank (PDB) archive currently holds > 155,000 atomic‐level 3D biomolecules experimentally determined using crystallography, nuclear magnetic resonance spectroscopy, electron...
The Worldwide PDB recently launched a deposition, biocuration, and validation tool: OneDep. At various stages of OneDep data processing, reports for three-dimensional structures biological macromolecules are produced. These based on recommendations expert task forces representing crystallography, nuclear magnetic resonance, cryoelectron microscopy communities. provide useful metrics with which depositors can evaluate the quality experimental data, structural model, fit between them. module...
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), funded by the US National Science Foundation, Institutes of Health, and Department Energy, has served structural biologists (PDB) data consumers worldwide since 1999. RCSB PDB, a founding member Worldwide (wwPDB) partnership, is center global PDB archive housing biomolecular structure data. also responsible security data, as wwPDB-designated Archive Keeper. Annually, serves tens thousands three-dimensional...
Abstract Summary: The Chemical Component Dictionary (CCD) is a chemical reference data resource that describes all residue and small molecule components found in Protein Data Bank (PDB) entries. CCD contains detailed descriptions for standard modified amino acids/nucleotides, ligands solvent molecules. Each definition includes of properties such as stereochemical assignments, descriptors, systematic names idealized coordinates. content, preparation, validation distribution this dataset are...
Abstract Now in its 52nd year of continuous operations, the Protein Data Bank (PDB) is premiere open‐access global archive housing three‐dimensional (3D) biomolecular structure data. It jointly managed by Worldwide (wwPDB) partnership. The Research Collaboratory for Structural Bioinformatics (RCSB PDB) funded National Science Foundation, Institutes Health, and US Department Energy serves as data center wwPDB. RCSB PDB also responsible security role wwPDB‐designated Archive Keeper. Every...
Approximately 87% of the more than 190,000 atomic-level three-dimensional (3D) biostructures in PDB were determined using macromolecular crystallography (MX). Agreement between 3D atomic coordinates and experimental data for >100 million individual amino acid residues occurring within ∼150,000 MX structures was analyzed detail. The real-space correlation coefficient (RSCC) calculated each residue experimental-data-derived electron density enables outlier detection unreliable (particularly...
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB, RCSB.org), the US Worldwide (wwPDB, wwPDB.org) data center global PDB archive, provides access to via its RCSB.org research-focused web portal. We report substantial additions tools and visualization features available at RCSB.org, which now delivers more than 227000 experimentally determined atomic-level three-dimensional (3D) biostructures stored in archive alongside 1 million Computed Structure Models...
Lactadherin is a phosphatidyl-L-serine (Ptd-L-Ser)-binding protein that decorates membranes of milk fat globules. The major Ptd-l-Ser binding function lactadherin has been localized to its C2 domain, which shares homology with the domains blood coagulation factor VIII and V. Correlating this homology, purified competes efficiently factors V for Ptd-L-Ser sites, functioning as potent anticoagulant. We have determined crystal structure domain (Lact-C2) at 1.7A resolution. bovine Lact-C2...
The Protein Data Bank (PDB) is the single global repository for experimentally determined 3D structures of biological macromolecules and their complexes with ligands. worldwide PDB (wwPDB) international collaboration that manages archive according to FAIR principles: Findability, Accessibility, Interoperability Reusability. wwPDB recently developed OneDep, a unified tool deposition, validation biocuration macromolecules. All data deposited undergo critical review by Biocurators. This article...