A growing amount of evidence has indicated that PSAT1 is an oncogene plays important role in cancer progression and metastasis. In this study, we explored the expression function estrogen receptor (ER)-negative breast cancer. The level tissues cells was analyzed using real-time-PCR (RT-PCR), TCGA datasets or immunohistochemistry (IHC). overall survival patients with ER-negative stratified by levels evaluated Kaplan-Meier analysis. a series vitro assays. Moreover, nude mouse model used to...

Eosinophil granule ontogeny transcript (EGOT) is a long noncoding RNA involved in the regulation of eosinophil protein expression. However, little known about role EGOT malignant disease. This study aimed to assess potential pathogenesis breast cancer. Quantitative real-time polymerase chain reaction was performed detect expression levels 250 cancerous tissues and 50 adjacent noncancerous tissues. The correlation with clinicopathological features prognosis also analyzed. lower cancer...

Understanding the causes of tumorigenesis and progression in triple-receptor negative breast cancer (TNBC) can help design novel personalized therapies prognostic assessments. Abnormal RNA modification is a recently discovered process TNBC development. samples from The Cancer Genome Atlas database were categorized according to expression level NAT10, which drives acetylation cytidine N(4)-acetylcytidine (ac4C) affects mRNA stability. A total 703 differentially expressed long non-coding RNAs...

Stem cell factor (SCF) and hypoxia-inducible factor-1α (HIF-1α) both have important functions in pancreatic ductal adenocarcinoma (PDAC). This study aims to analyze the expression clinicopathological significance of SCF HIF-1α PDAC specimens explore molecular mechanism at cells vitro vivo. We showed that was significantly correlated with via Western blot, PCR, chromatin immunoprecipitation (ChIP) assay, luciferase assay analysis. The level also lymph node metastasis pathological tumor (pTNM)...

Background: Accumulating evidence indicates that PSAT1 not only reprogrammed metabolic function but also exhibits “moonlighting” functions in promoting tumor malignancy. However, the underlying molecular mechanisms of ER-negative breast cancer cell migration need further investigation. Methods: Briefly, and ITGA2 expression cells tissues was detected using qRT-PCR, immunofluorescence staining western blot assay. The effect verified both vitro vivo. RNA-seq analysis explored a series...

Complement 1q binding protein (C1QBP/HABP1/p32/gC1qR) has been found to be overexpressed in triple-negative breast cancer (TNBC). However, the underlying mechanisms of high C1QBP expression and its role TNBC remain largely unclear. Hypoxia is a tumor-associated microenvironment that promotes metastasis paclitaxel (PTX) chemoresistance tumor cells. In this study, we aimed assess explore hypoxia-related TNBC.RNA-sequencing cells under hypoxia was performed identify C1QBP. The effect inducible...

Electronic Skin In article number 2202622, by integrating the triboelectric effect with supercapacitive iontronic effect, Yang Li, Guozhen Shen, and co-workers report an artificial intelligence (AI)-motivated full-skin bionic (FSB) e-skin based on vellus hair epidermis–dermis–hypodermis double interlocked microcone structures demonstrate its smart application prospects from tactile perception to advanced intelligent cognition.

Abstract The discovery of nanozymes has opened new possibilities for tumor therapy. However, their reliance on the microenvironment and limited catalytic efficiency hinder broader applications. In this study, ruthenium‐phenanthroline nanoparticles (Ru‐Phs) are synthesized by combining ruthenium with phenanthroline subsequently coloaded proton pump inhibitor (PPI) pantoprazole into sodium alginate (ALG) to form a Ru‐Phs‐PPI‐ALG hydrogel in situ This demonstrates excellent chemodynamic...

Abstract Background Studies have shown that abnormal changes of specific-gene DNA methylation in leukocytes may be associated with an elevated risk cancer. However, associations between the zinc-related genes, WT1 and CA10 , breast cancer remain unknown. Methods The was analyzed by methylation-sensitive high-resolution-melting (MS-HRM) a case-control study female subjects ( N = 959). Logistic regression used to analyze associations, propensity score (PS) method adjust confounders. Results...

Objectives: Breast malignancy is a serious threat to women's health around the world. Following rapid progress in field of cancer diagnostics and identification pathological markers, breast tumor treatment methods have been greatly improved. However, for invasive, ductal carcinomas mammary fibroadenoma, there an urgent demand better tumor-linked biomarkers. The current study was designed identify diagnostic and/or therapeutic protein biomarkers tumors. Methods: A total 140 individuals were...

To date, breast cancer remains the most common malignant tumor in women. In recent years, a growing number of studies on polycomb proteins have been conducted. The Ring finger protein1 (RING1), an essential component family proteins, plays vital roles tumorigenesis various types. However, further research is required determining RING1 expression and prognostic value cancer.RING1 level multiple types was evaluated using XENA UALCAN databases. Real-time quantitative PCR (real-time qPCR)...

Introduction: Breast cancer is a commonly diagnosed cancer, in which most patients' metastases (about 75%) occurred 5 years after the initial diagnosis, especially 3 years. Recrudescence exceeding 20 rarely reported past several decades. Case information: A 68-year-old female patient presented with breast focal increased 18F-fluorodeoxyglucose uptake right supraclavicular lymph node, mediastinum and sternum were found on positron emission tomography computed tomography. Then we learned that...

Standardized methods for the detection and assessment of circulating tumor DNA (ctDNA) in breast cancer are not sufficient. In present study, method potential application ctDNA diagnosis were explored. was extracted from tissues, plasma peripheral blood cells 11 patients with early-stage invasive cancer. Primers designed against exons phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit α, p53, epidermal growth factor receptor, Akt phosphatase tensin homolog. The amplicon-based...

Background: Primary triple-negative breast cancer (TNBC) is influenced by hypoxic microenvironments that promote metastasis and paclitaxel (PTX) resistance. However, few studies have attempted to understand how hypoxia promotes drug resistance provide a solution these problems, especially in TNBC. Methods: Transcriptome sequencing of TNBC cells under conditions was performed identify C1QBP. The mechanism HIF-1α induced C1QBP both normoxia were investigated ChIP-qPCR. Next the role mediating...

Objective To investigate the apoptosis of pancreatic cancer xenograft after irreversible electroporation (IRE) treatment, and observe antitumor effect safety IRE technique. Methods Twelve New Zealand white rabbits with were randomly divided into treatment group (n=10) control (n=2). The received IRE; no treatment. Two sacrificed at 1st, 3rd, 5th, 7th, 14th day blood plasma or serum was separated to detect liver renal function, amylase, creatine kinase, caspase-3, TNF-α, VEGF, CTnI....

In order to improve the construction of shield, an intelligent and integrated information system for shield is designed. Ground Penetrating Radar(GPR) installed in cutter disc first time explore frontal geology real continuously. Based on route deviation influence geological conditions construction, a compound control with double structure designed shield. The published be shared by all authorized users. This scheme important intelligence infomationization which innovative valuable...

Objective To study the correlation of MGMT gene promoter methylation and protein expression their regional variation in different specimens obtained from regions within tumor patients with newly diagnosed glioblastoma. Methods Two to four samples same were collected 30 glioblastoma patients. In five among them,mutispecimens under assistance neuronavigation system during operation. all samples,MGMT profile analyzed by Methylation - specific polymerase Chain reaction analysis, MSP ,while was...

Abstract MicroRNAs (miRs) have potential as non-invasive biomarkers, but their relevance biomarkers is limited by inconsistent results, and regulatory mechanisms remain elusive. In the present study, our results show that levels of miR-200c 141 in tumor cells circulation differ for mice humans between cases with metastatic breast cancer, localized healthy female controls. The are low primary high patients cancer. Further, we suggest cell origin circulating describe transcriptional regulation...