A5101542220- Cancer-related molecular mechanisms research
- Laser Applications in Dentistry and Medicine
- MicroRNA in disease regulation
- Cardiac Valve Diseases and Treatments
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Cardiac Fibrosis and Remodeling
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Photodynamic Therapy Research Studies
- Infrared Thermography in Medicine
- Calpain Protease Function and Regulation
- Gene Regulatory Network Analysis
- Bacterial Genetics and Biotechnology
- Medical and Biological Ozone Research
- Epigenetics and DNA Methylation
- Spaceflight effects on biology
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- RNA regulation and disease
- Cancer, Hypoxia, and Metabolism
- Hydrogen's biological and therapeutic effects
- RNA and protein synthesis mechanisms
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Shanghai Ninth People's Hospital
2025
Shanghai Jiao Tong University
2020-2025
Harbin Medical University
2015-2024
Affiliated Hospital of Nantong University
2020-2024
Nantong University
2020-2024
Heilongjiang Academy of Sciences
2022-2023
First People's Hospital of Yunnan Province
2021
Tongren Hospital
2020
Ischemic cardiac disease is the leading cause of morbidity and mortality in world. Despite great efforts progress research, current treatment ischemia reperfusion injury (I/RI) still far from being satisfactory. This study was performed to investigate role long non-coding RNA (lncRNA) H19 regulating myocardial I/RI. We found that expression downregulated I/R hearts mice cardiomyocytes treated with H2O2. Overexpression alleviated I/RI cardiomyocyte induced by functioned as a competing...
Ku70 participates in several pathological processes through mediating repair of DNA double-strand breaks. Our previous study has identified a highly conserved long noncoding RNA cardiac ischemia reperfusion associated interacting lncRNA (CIRKIL) that was upregulated myocardial infarction. The aims to investigate whether CIRKIL regulates ischemia/reperfusion (I/R) binding Ku70. transgenic and knockout mice were subjected 45-minute 24-hour establish I/R model. pull-down immunoprecipitation...
Abstract Cardiac ischemia–reperfusion (I/R) injury is a pathological process resulting in cardiomyocyte death. The present study aims to evaluate the role of long noncoding RNA Injury-Related Bclaf1-Inhibiting LncRNA (lncCIRBIL) on cardiac I/R and delineate its mechanism action. level lncCIRBIL reduced hearts. Cardiomyocyte-specific transgenic overexpression reduces infarct area following injury. Knockout mice exacerbates Qualitatively, same results are observed vitro. LncCIRBIL directly...
Abstract Cardiomyocyte apoptosis is an important process occurred during cardiac ischaemia‐reperfusion injury. Long non‐coding RNAs (lncRNA) participate in the regulation of various diseases including ischaemic reperfusion (I/R) In this study, we explored potential role lncRNA ACART (anti‐cardiomyocyte apoptosis‐related transcript) cardiomyocyte injury and underlying mechanism for first time. We found that was significantly down‐regulated tissue mice subjected to I/R or cultured...
Osteoporotic bone regeneration is challenging due to impaired formation. Tetrahedral DNA nanostructures (TDN), promising nucleic acid nanomaterials, have garnered attention for their potential in osteoporotic mandibular owing ability enhance cellular activity and promote osteogenic differentiation. Osteoblasts play a critical role regeneration; however, intracellular delivery of TDN into osteoblasts remains difficult. In this study, novel osteoblast-targeted CH6 aptamer-functionalized...
Synthetic biologists have developed DNA/molecular modules that perform genetic logic operations in living cells to track key moments a cell's life or change the fate of cell. Increasing evidence has also revealed diverse gates capable generating Boolean function play critically important roles synthetic biology. Basic been designed combine biological science with digital logic. SynBioLGDB ( http://bioinformatics.ac.cn/synbiolgdb/ ) aims provide biology community useful resource for efficient...
Tongue cancer is one of the most common types cancer, but its molecular etiology and pathogenesis remain unclear. The aim present study was to elucidate tongue investigate novel potential diagnostic therapeutic targets. Four matched pairs paracancerous tissues were collected for RNA sequencing (RNA‑Seq), differentially expressed genes analyzed. RNA‑Seq data further analyzed using bioinformatics reverse transcription‑quantitative PCR analysis. sequenced reads quantified qualified in...
Abstract Background The present study aimed to explore the biological role and underlying mechanism of long non‐coding RNA actin filament‐associated protein 1‐antisense RNA1 (lncRNA AFAP1‐AS1) in progression tongue squamous cell carcinoma (TSCC). Methods A quantitative reverse transcriptase‐PCR (RT‐qPCR) was conducted assess relative levels miR‐133a‐5p, lncRNAs AFAP1‐AS1 zinc finger family member 2 (ZIC2) TSCC lines specimens, whereas ZIC2 were measured using western blotting. After...
Background: Sepsis-induced acute lung injury (ALI) is a clinical syndrome characterized by excessive uncontrolled inflammation. Photobiomodulation such as light-emitting diode (LED) irradiation has been used to attenuate inflammatory disease. Objective: The protective effect of 630 nm LED on sepsis-induced ALI remains unknown. purpose this study was investigate the role in and its underlying mechanism. Methods results: C57BL/6 mice were performed cecal ligation puncture (CLP) for 12 h...
Background: Photobiomodulation (PBM) is praised as a promising physical therapy, which has many advantages, such being noninvasive and painless. However, the mechanisms are not fully elucidated. Methods: Using web crawling, mRNA sequence, bioinformatics analysis, we selected genes, functional annotation, mechanisms. The expressions of inflammatory cytokines were measured using quantitative real-time PCR (RT-qPCR). Results: A total 146 human genes 57 pathways identified about PBM. 630 nm...
Background: Inflammatory cytokine secretion from fibroblast-like synoviocytes (FLS) plays a vital role in the pathological process of rheumatoid arthritis (RA). Photobiomodulation (PBM) has been widely used treatment RA. However, mechanism PBM RA not clarified. Objective: In this study, we investigated underlying 630 nm light-emitting diode (LED) irradiation on anti-inflammation using mRNA sequencing analysis. Methods and results: Reverse transcription (RT)-quantitative polymerase chain...
Background: Primary triple-negative breast cancer (TNBC) is influenced by hypoxic microenvironments that promote metastasis and paclitaxel (PTX) resistance. However, few studies have attempted to understand how hypoxia promotes drug resistance provide a solution these problems, especially in TNBC. Methods: Transcriptome sequencing of TNBC cells under conditions was performed identify C1QBP. The mechanism HIF-1α induced C1QBP both normoxia were investigated ChIP-qPCR. Next the role mediating...