A5112840459- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cardiac electrophysiology and arrhythmias
- Cardiac Fibrosis and Remodeling
- RNA regulation and disease
- Fuel Cells and Related Materials
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Signaling Pathways in Disease
- Atrial Fibrillation Management and Outcomes
- Receptor Mechanisms and Signaling
- Ubiquitin and proteasome pathways
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Peptidase Inhibition and Analysis
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Heat shock proteins research
- Cell death mechanisms and regulation
- Autonomous Vehicle Technology and Safety
- Maritime Navigation and Safety
- Tissue Engineering and Regenerative Medicine
- Medical Imaging and Analysis
- Cardiac Arrhythmias and Treatments
- Connective tissue disorders research
Harbin Medical University
2017-2025
Dalian Medical University
2022-2025
First Affiliated Hospital of Dalian Medical University
2022-2025
Wenzhou University of Technology
2025
Wenzhou University
2025
Shandong Normal University
2024
China Ocean Shipping (China)
2016
Ministry of Education
2016
Sun Yat-sen University
1990
Abstract Interleukin 6 (IL-6) has been shown to be an important regulator of cardiac interstitial fibrosis. In this study, we explored the role interleukin-6 in development diabetic cardiomyopathy and underlying mechanisms. Cardiac function IL-6 knockout mice was significantly improved fibrosis apparently alleviated comparison with wildtype (WT) induced by streptozotocin (STZ). Treatment promoted proliferation collagen production cultured fibroblasts (CFs). High glucose treatment increased...
Heart failure (HF) is a major cause of morbidity and mortality in patients with various cardiovascular diseases. Restoration cardiac function critical improving the clinical outcomes HF. Long noncoding RNAs are widely involved development multiple diseases, whereas their role regulating remains unclear. In this study, we found that expression long RNA-DACH1 (dachshund homolog 1) was upregulated failing hearts mice human. We tested hypothesis intronic RNA DACH1 (LncDACH1) can participate...
Abstract Cardiac ischemia–reperfusion (I/R) injury is a pathological process resulting in cardiomyocyte death. The present study aims to evaluate the role of long noncoding RNA Injury-Related Bclaf1-Inhibiting LncRNA (lncCIRBIL) on cardiac I/R and delineate its mechanism action. level lncCIRBIL reduced hearts. Cardiomyocyte-specific transgenic overexpression reduces infarct area following injury. Knockout mice exacerbates Qualitatively, same results are observed vitro. LncCIRBIL directly...
ASPP1 (apoptosis stimulating of p53 protein 1) is critical in regulating cell apoptosis as a cofactor to promote its transcriptional activity the nucleus. However, whether cytoplasmic affects nuclear trafficking and role cardiac diseases remains unknown. This study aims explore mechanism by which modulates subsequent contribution ischemia/reperfusion (I/R) injury.The immunofluorescent staining showed that under normal condition colocalized cytoplasm neonatal mouse ventricular cardiomyocytes,...
G protein-coupled receptors play a critical role in atrial fibrillation (AF). Spexin is novel ligand of galanin (GALRs). In this study, we investigated the regulation spexin and GALRs on AF underlying mechanisms.
Dystrophin is a critical interacting protein of Nav1.5 that determines its membrane anchoring in cardiomyocytes. Long noncoding RNAs (lncRNAs) are involved the regulation cardiac ion channels, while their influence on sodium channels remains unexplored. Our preliminary data showed lncRNA- Dachshund homolog 1 ( lncDach1 ) can bind to dystrophin, which drove us investigate if regulate by interfering with dystrophin. Western blot and immunofluorescent staining cardiomyocyte-specific transgenic...
Abstract Myocardial ischemia/reperfusion (MI/R) injury is a pathological process that seriously affects the health of patients with coronary artery disease. Long non-coding RNAs (lncRNAs) represents new class regulators diverse biological processes and disease conditions, study aims to discover pivotal lncRNA in MI/R injury. The microarray screening identifies down-regulated heart-enriched lncRNA-CIRPIL (Cardiac ischemia reperfusion associated p53 interacting lncRNA, lncCIRPIL) from hearts...
Background: Recent clinical trials indicate that sodium–glucose cotransporter 2 (SGLT2) inhibitors improve cardiovascular outcomes in myocardial infarction (MI) patients, but the underlying mechanisms remain unknown. As arrhythmia often occurs during infarction, it is main cause of death. Objective: The purpose this study was to investigate influence empagliflozin (EMPA), an SGLT2 inhibitor, on cardiac electrophysiological remodeling and susceptibility mice. Methods: ECG obtained from mice 1...
Abstract Introduction: Deficiency of testosterone was associated with the susceptibility atrial fibrillation (AF). Angiotensin‐II (AngII) receptor antagonists were shown to reduce AF by improving electrical remodeling. This study investigated effects and mechanism valsartan, an AngII antagonist, on deficiency. Methods Results: Five‐week‐old male ICR mice castrated valsartan administered orally (50 mg/kg/d). High‐frequency stimulation method used induce arrhythmia. Patch‐clamp technique for...
The principal voltage-gated Na+ channel, NaV1.5 governs heart excitability and conduction. dysregulation is responsible for ventricular arrhythmias subsequent sudden cardiac death (SCD) in post-infarct hearts. transcription factor Meis1 performs a significant role determining differentiation fate regenerative capability of cardiomyocytes. However, the functions ischemic following myocardial infarction (MI) are still largely undefined.Here we aimed to study whether could act as key regulator...
<title>Abstract</title> Dystrophin is a critical interacting protein of Nav1.5 that determines its membrane anchoring in cardiomyocytes. Long noncoding RNAs (lncRNAs) are involved the regulation cardiac ion channels, while their influence on sodium channel remains unexplored. Our preliminary data showed lncRNA-Dachshund homolog 1 (lncDACH1) can bind to dystrophin, which drove us investigate if lncDACH1 regulate by interfering with dystrophin. Western blot and immunofluorescent staining...
Dystrophin is a critical interacting protein of Nav1.5 that determines its membrane anchoring in cardiomyocytes. Long noncoding RNAs (lncRNAs) are involved the regulation cardiac ion channels, while their influence on sodium channel remains unexplored. Our preliminary data showed lncRNA-Dachshund homolog 1 (lncDACH1) can bind to dystrophin, which drove us investigate if lncDACH1 regulate by interfering with dystrophin. Western blot and immunofluorescent staining cardiomyocyte-specific...