A5101808720- Renal Diseases and Glomerulopathies
- Diabetes Treatment and Management
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Pediatric Urology and Nephrology Studies
- Systemic Lupus Erythematosus Research
- Cancer, Hypoxia, and Metabolism
- Ovarian cancer diagnosis and treatment
- Cancer Cells and Metastasis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pancreatic and Hepatic Oncology Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chemokine receptors and signaling
- Traditional Chinese Medicine Studies
- Cardiovascular Health and Disease Prevention
- Lung Cancer Treatments and Mutations
- Ion Transport and Channel Regulation
- Lymphatic System and Diseases
- Radiation Therapy and Dosimetry
- Glaucoma and retinal disorders
- Histone Deacetylase Inhibitors Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Signaling Pathways in Disease
- Urticaria and Related Conditions
- RNA modifications and cancer
Wuhan University
2018-2025
Renmin Hospital of Wuhan University
2018-2025
Nanjing Medical University
2024
Fujian Provincial Cancer Hospital
2022-2024
Fujian Medical University
2022-2024
Zhejiang International Studies University
2023
Zhejiang University
2023
University of Copenhagen
2023
Tianjin Medical University Cancer Institute and Hospital
2012-2022
Sanofi (China)
2020-2022
Pancreatic cancer (PC) is the most lethal type of gastrointestinal cancer, and early detection monitoring an urgent problem. Circulating tumor cells (CTCs) are emerging as a non-invasive biomarker for detection. However, low sensitivity main problem in traditional CellSearch System detecting CTCs, especially patients with PC. In this study, we used negative enrichment (NE), immunofluorescence situ hybridization (FISH) chromosome 8 (NE-iFISH) to capture identify CTCs PC patients. We showed...
Objective To analyse retinal and choroidal microvascular alterations in patients with thyroid-associated ophthalmopathy (TAO) hyperthyroidism without signs of TAO using swept-source optical coherence tomography angiography (SS-OCTA) to investigate the potential reasons for ocular changes TAO.
CX3CR1 is an important chemokine receptor and regulates the chemotactic migration of pancreatic ductal adenocarcinoma (PDAC) cells. Up to now, its regulatory mechanism remains largely undefined. Here, we report that hypoxia upregulates expression in cancer When hypoxia-inducible factor (HIF)-1α was knocked down vitro vivo, significantly decreased. Chromatin immunoprecipitation assay demonstrated HIF-1α bound hypoxia-response element (HRE; 5'-A/GCGTG-3') promoter under normoxia, this binding...
Background. Since the identification of NPHS2 gene, various investigators have demonstrated that an mutation is a frequent cause sporadic steroid-resistant nephrotic syndrome (SRNS), and occurs in 10.5–28% children with syndrome. Idiopathic (INS) also most glomerular disease Chinese children, which ∼20% cases show steroid resistance. To our knowledge, however, whether or not causative gene SRNS has been established. This study aims to examine mutations SRNS. Methods. We examined 23 for...
Abstract In the field of content generation by machine, state-of-the-art text-to-image model, DALL⋅E, has advanced and diverse capacities for combinational image with specific textual prompts. The images generated DALL⋅E seem to exhibit an appreciable level creativity close that humans in terms visualizing a idea. Although there are several common metrics which can be applied assess quality generative models, such as IS, FID, GIQA, CLIP, it is unclear whether these equally applicable...
Hypoxia-inducible factor-1α (HIF-1α) is a highly important transcription factor involved in cell metabolism. HIF-1α promotes glycolysis and inhibits of mitochondrial respiration pancreatic ductal adenocarcinoma (PDAC). In response to tumor hypoxia, cyclophilin A (CypA) over-expressed various cancer types, associated with apoptosis, invasion, metastasis, chemoresistance PDAC. this study, we showed that both CypA expression were significantly lymph node metastasis stage. The was correlated...
Stem cell factor (SCF) and hypoxia-inducible factor-1α (HIF-1α) both have important functions in pancreatic ductal adenocarcinoma (PDAC). This study aims to analyze the expression clinicopathological significance of SCF HIF-1α PDAC specimens explore molecular mechanism at cells vitro vivo. We showed that was significantly correlated with via Western blot, PCR, chromatin immunoprecipitation (ChIP) assay, luciferase assay analysis. The level also lymph node metastasis pathological tumor (pTNM)...
To investigate the molecular mechanism of osteoclast-derived exosomes in osteoporosis.
To investigate the effect of acarbose therapy on long-term prognosis patients with acute coronary syndromes (ACS) complicating newly diagnosed impaired glucose tolerance (IGT).135 hospitalized for ACS who had been IGT were randomly assigned to group (150 mg/day, n = 67) or control (no acarbose, 68). All cases in each given same elementary treatment. Mean follow-up was 2.3 years. The incidence major adverse cardiovascular event (MACE) and carotid intima-middle thickness (CIMT) statistically...
One of the hallmarks cancer is revised glucose metabolism that promotes cell survival and proliferation. In pancreatic cancer, regulatory mechanism remains to be elucidated. this study, we found CX3CR1 expressed in cells lines. Exogenous or transfected CX3CL1 increased uptake lactate secretion. stimulated HIF-1 expression through PI3K/Akt MAPK pathways. Furthermore, knockdown blocked CX3CL1-modified adenocarcinoma cells. conclusion, CX3CL1/CX3CR1 reprograms pathway J. Cell. Biochem. 114:...
Over the past two decades, incidence of endometrial cancer (EC) is increasing, and there a need for molecular biomarkers to predict prognosis guide treatment. A recent study from The Cancer Genome Atlas suggested implement EC analysis by profile improving diagnosis, prognosis, therapeutic In this study, next-generation sequencing was performed on 70 cases G3 endometrioid ECs (EECs) using an 11-gene panel (TP53, MLH1, MSH2, MSH6, PMS2, EPCAM, PIK3CA, CTNNB1, KRAS, PTEN, POL) classification....
Abstract Aim To compare the efficacy and safety of basal insulin glargine 100 units/ml (Gla) + 2‐3 oral antihyperglycaemic drugs (OADs) with twice‐daily premixed aspart 70/30 (Asp30) metformin (MET) after short‐term intensive therapy in adults type 2 diabetes China. Materials Methods This open‐label trial enrolled insulin‐naïve an HbA1c 7.5%‐11.0% (58‐97 mmol/mol) despite treatment OADs. All participants stopped previous OADs except MET, then received during run‐in period, when those a...
Abstract Aim To determine the relationship between eNOS uncoupling and diabetic ischemic foot whether reversing by Dihydrofolate reductase (DHFR) transfection or folic acid (FA) supplementation can be beneficiary in foot. Methods The bilateral common iliac artery of rats were ligated to establish animal model. DHFR was implemented via femoral muscle injection vivo reagent mixture (GenEscortIII) every 4 days during 2 weeks intervention. color doppler flow imaging (CDFI) for RI measurement,...
Melanoma segmentation based on a convolutional neural network (CNN) has recently attracted extensive attention. However, the features captured by CNN are always local that result in discontinuous feature extraction. To solve this problem, we propose novel multiscale fusion (MSFA-Net). MSFA-Net can extract information at different scales through structure (MSF) and then calibrate restore extracted to achieve purpose of melanoma segmentation. Specifically, popular encoder-decoder structure,...
Tumor-associated lymph vessels and node involvement are critical staging criteria in several cancers. In skin squamous cell carcinoma, play a role cancer development metastatic spread. However, their relationship with the stem niche at early tumor stages remains unclear. To address this gap, we studied vessel localization observed an association from benign lesions to malignant of carcinoma. By co-culturing lymphatic endothelial cells lines representing initiation promotion stages,...
To investigate the impact of denoising on qualitative and quantitative parameters optical coherence tomography angiography (OCTA) images optic nerve macular area. OCTA area were obtained using a Canon-HS100 OCT device for 48 participants (48 eyes). Multiple image averaging (MIA) techniques used to improve quality images. The peak signal-to-noise ratio (PSNR) as an parameter vessel density (VD) from single-scan, MIA, denoised compared, correlation was analyzed between different imaging...