A5101640940- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Advanced Drug Delivery Systems
- Glycogen Storage Diseases and Myoclonus
- Moyamoya disease diagnosis and treatment
- Neurological diseases and metabolism
- MicroRNA in disease regulation
- Viral Infections and Immunology Research
- Eosinophilic Disorders and Syndromes
- Drug Solubulity and Delivery Systems
- Synthesis and biological activity
- Eosinophilic Esophagitis
- Ion Transport and Channel Regulation
- RNA regulation and disease
- Intracranial Aneurysms: Treatment and Complications
- Psoriasis: Treatment and Pathogenesis
- Immune Response and Inflammation
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Metalloenzymes and iron-sulfur proteins
- Synthesis and Characterization of Heterocyclic Compounds
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Cerebrovascular and genetic disorders
Second Affiliated Hospital of Zhejiang University
2016-2023
Sichuan University
2016
Shenyang Pharmaceutical University
2016
Southeast University
2016
Johns Hopkins University
2011-2013
Oral delivery of protein drugs based on nanoparticulate system requires permeation the nanoparticles through mucus layer and subsequent absorption via epithelial cells. However, overcoming these two barriers very different or even contradictory surface properties nanocarriers, which greatly limits oral bioavailability macromolecular drugs. Here we report a simple zwitterions-based nanoparticle (NP) platform, showed great potency in simultaneously both epithelium barriers. The dense...
The involvement of macrophages (MΦs) in Th17-cell responses is still poorly understood. While neutrophils are thought to be the predominant effector responses, IL-17 also known induce myelotropic chemokines and growth factors. Other T-cell-derived cytokines non-classical functions, suggesting that sigxnaling may similarly elicit unique MΦ functions. Here, we characterized expression subunits receptor on primary murine MΦs from different anatomical compartments. greatest receptors was...
CD4(+) T cells play a central role in inflammatory heart disease, implicating cytokine product associated with Th cell effector function as necessary mediator of this pathophysiology. IFN-γ-deficient mice developed severe experimental autoimmune myocarditis (EAM), which are immunized cardiac myosin peptide, whereas IL-17A-deficient were protected from progression to dilated cardiomyopathy. We generated IFN-γ(-/-)IL-17A(-/-) assess whether IL-17 signaling was responsible for the EAM...
Summary Aim To characterize clinical features and mutation spectrum in Chinese patients with CADASIL . Methods We collected 261 clinically suspected from three hospitals located different regions of China. Sanger sequencing is performed to screen the exons 2 24 NOTCH 3 gene. Clinical genetic data were retrospectively studied. Haplotype analyses carrying p.Arg544Cys p.Arg607Cys, respectively. Results A total 214 finally genetically diagnosed as , 45 known mutations a novel c.1817G>T...
Abstract Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS characterized by demyelination and axonal damage. Experimental autoimmune encephalomyelitis (EAE) well-established animal model for human MS. Although Th17 cells are important induction, Th2 inhibitory in this process. In article, we report effect cell product, extracellular matrix protein 1 (ECM1), on differentiation development EAE. Our results demonstrated that ECM1 administration from day to 7 following EAE...
We designed dual-peptide-functionalized fluorescence-SERS dual mode imaging nanoprobes possessing an improved cancer cell targeting efficiency.
Background: Multiple sclerosis (MS) is a common central nervous system autoimmune disorder. Increasing number of genome-wide association study (GWAS) analyses hint that MS strongly associated with genetics. Unfortunately, almost all the GWAS were Caucasian population based. Numbers risk loci might not be replicated in Chinese patients. Hence, we performed MassArray Assay to genotype previously reported variants located transcription regulation genes order elucidate their role Methods: One...
Andersen-Tawil syndrome (ATS) is a rare cause of periodic paralysis.The inheritance pattern ATS autosomal dominant.It characterized by paralysis, arrhythmias, and distinctive appearances. [1]ATS has been linked to mutations in the KCNJ2 gene that causes defective inward-rectifi er potassium channel Kir2.1, [2] which plays an important role stabilizing resting membrane potential both skeletal cardiac muscles. [3]There are few reports [4,5] concerning Chinese population.The potentially...