A5003664323- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Extracellular vesicles in disease
- Liver physiology and pathology
- Ubiquitin and proteasome pathways
- Tryptophan and brain disorders
- Liver Disease Diagnosis and Treatment
- Ion Channels and Receptors
- Liver Diseases and Immunity
- IL-33, ST2, and ILC Pathways
Chengdu Third People's Hospital
2022-2025
Southwest Jiaotong University
2022-2025
Chongqing Medical University
2022
Psychological stress disrupts the integrity of intestinal barrier and is strongly linked to emotional disorders, behavioral changes, gastrointestinal dysfunction. However, there are limited treatment options available for repairing damage barrier. As a natural plant-based health beverage, tea (Camellia sinensis) has been shown have various potentially advantageous effects on immune function. In this study, we extracted bioactive molecules from leaves, named exosome-like nanoparticles (ELNs),...
The activation of hepatic stellate cells (aHSCs) play a role for the occurrence and progression liver fibrosis. However, effective drugs that can prevent or reverse this pathological process remain unavailable. Zanthoxylum bungeanum Maxim. (Rutaceae) is an edible medicinal plant with diverse bioactivities, including antiparasitic, antimicrobial, anti-inflammatory effects. This study investigates therapeutic potential underlying mechanisms bungeanum-derived extracellular vesicles (ZEVs) in...
Recent research has increasingly focused on plant-derived products as potential alternatives to chemotherapeutic agents, aiming reduce side effects. Among these, nanovesicles (NVs) have garnered significant attention for their in treating colitis. In this study, we extracted NVs from the leaves (LNVs) and stems (SNVs) of Taxus, a well-known natural anti-cancer plant. The targeting ability these was evaluated mouse colon using an IVIS imaging system. Additionally, assessed therapeutic effects...
Activation of hepatic stellate cells (HSCs) is essential for the pathogenesis liver fibrosis, there no effective drug used to prevent or reverse fibrotic process.With human cell line LX-2 and mouse model CCl4-induced we investigated anti-fibrotic effect fibrosis extracellular vesicles (EVs) extracted from tea leaves through cytological tests such as proliferation, migration, marker.It was found that tea-derived EVs (TEVs) inhibited HSCs activation. In model, TEVs treatment can significantly...
Exosome-like nanoparticles (ELNs) have emerged as crucial mediators of intercellular communication, evaluated potential bioactive nutraceutical biomolecules. We hypothesized that oral ELNs some therapeutic effect on irritable bowel syndrome (IBS).