A5100367456- Pancreatic function and diabetes
- Orthopaedic implants and arthroplasty
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
- Metabolism, Diabetes, and Cancer
- Respiratory and Cough-Related Research
- Total Knee Arthroplasty Outcomes
- Immunotherapy and Immune Responses
- Diet, Metabolism, and Disease
- Transgenic Plants and Applications
- Coronary Interventions and Diagnostics
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Orthopedic Infections and Treatments
- Cardiac Imaging and Diagnostics
- CRISPR and Genetic Engineering
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Cardiac and Coronary Surgery Techniques
- Acute Myocardial Infarction Research
- Supramolecular Chemistry and Complexes
- Consumer Attitudes and Food Labeling
- Phytoestrogen effects and research
- Hemostasis and retained surgical items
- CAR-T cell therapy research
Sichuan University
2012-2025
Chengdu Women's and Children's Central Hospital
2025
Chengdu Medical College
2025
Nanjing Institute of Agricultural Mechanization
2024
Ministry of Agriculture and Rural Affairs
2024
West China Hospital of Sichuan University
2006-2024
First Affiliated Hospital of Harbin Medical University
2024
Harbin Medical University
2024
Bethune International Peace Hospital
2020-2023
Zhejiang University
2020
Abstract Our aim was to clarify the incidence and risk of acute symptomatic seizures in people with coronavirus disease 2019 (COVID‐19). This multicenter retrospective study enrolled COVID‐19 from January 18 February 18, 2020 at 42 government‐designated hospitals Hubei province, epicenter epidemic China; Sichuan province; Chongqing municipality. Data were collected medical records by 11 neurologists using a standard case report form. A total 304 enrolled, whom 108 had severe condition. None...
Collagen type I alpha 1 chain (COL1A1) is a key protein encoding fibrillar collagen, playing crucial role in the tumor microenvironment (TME) due to its complex functions and close association with invasiveness. This has made COL1A1 focal point cancer biology research. However, studies investigating relationship between expression levels clinical characteristics of ovarian (OC) remain limited. study integrated resources from publicly available online databases immunohistochemistry (IHC)...
Abstract Aim To achieve glucose‐activated transcriptional regulation of insulin analogue in skeletal muscle T1D mice, thereby controlling blood glucose levels and preventing or mitigating diabetes‐related complications. Materials Methods We developed the GANIT ( G lucose‐ A ctivated N FAT‐regulated I NSA‐F T ranscription) system, an innovative platform building upon previously established intramuscular plasmid DNA (pDNA) delivery expression system. In cells are genetically engineered to...
China’s livestock industry grapples with challenges posed by infectious diseases and the misuse of antibiotics, resulting in a heightened risk drug-resistant pathogens. This study explored immunomodulatory effects co-expressing porcine interleukin 3, 7, 15 Yarrowia lipolytica, denoted as Po1h-IL-3/7/15. A 42-day experiment involving mouse immunization pathogen challenge was conducted, during which vivo assessments antibodies, immune-related cells, gene expression were detected following oral...
The fabrication and drug delivery of novel polypseudorotaxane micelles with small molecule coumarin derivative as hydrophobic segment were reported. 7-Carboxymethoxy was immobilized on the terminal hydroxyl groups poly(ethylene glycol) (PEG). modified PEG chains threaded in α-cyclodextrins (α-CDs) to form polypseudorotaxanes. polypseudorotaxanes self-assembled into supramolecular driven by interaction crystallization. Anti-tumor doxorubicin (DOX) trapped micelles. structure, morphology,...
The aim of this retrospective study was to probe into clinicopathological features and prognosis early-onset gastric cancer (EOGC) patients aged ≤ 45 years old.This selected 154 young old 158 elderly > 50 admitted West China Hospital Sichuan University in 2009-2019 as the research object. These were further divided two groups according whether tumor can be resected radically. following parameters analyzed: age, gender, helicobacter pylori (HP) infection status, Her-2 pathological type stage,...
The role of phytoestrogens in asthma/wheeze and lung function remains controversial. Thus, we aimed to examine whether have beneficial effects on asthma/wheeze, for subgroups mortality.
To address the requirements of direct corn kernel harvesting in Huang-Huai-Hai region China, this study aimed to rectify issues related damage and low threshing rates observed operation existing machines. Initially, a novel device was designed, incorporating staggered rotary motions for cylinder concave grate. Subsequently, experimental factors such as speed drum, grate gap were considered on test bench, indexes grain crushing rate evaluated.Moreover, orthogonal testing indicated that...
Daily insulin injection is necessary for the treatment of insulin-dependent diabetes. However, process painful and inconvenient. Accordingly, we have made exploratory efforts to establish an alternative method continuous supply via intramuscular a designed plasmid encoding single-strand analogue (SIA), which provides safe, effective prolonged control To generate SIA, short flexible peptide was alternatively introduced into natural proinsulin replace its original long rigid C-peptide. Then,...
Introduction: As heterologous islets or islet-like stem cells become optional sources for islet transplantation, the subcutaneous site appears to be an acceptable replacement of intrahepatic due its graft retrievability.The device-less (DL) procedure improves feasibility; however, some limitations such as fibrotic overgrowth immunodeficiency still exist.Nanofibers could mimic extracellular matrix improve vitality transplanted islets.Therefore, we designed a vascular endothelial growth factor...
Genetic modification of non–β-cells to produce insulin is a promising therapeutic strategy for type 1 diabetes; however, it associated with issues, including biosafety and precise regulation supply. In this study, glucose-activated single-strand analog (SIA) switch (GAIS) was constructed achieve repeatable pulse activation SIA secretion in response hyperglycemia. the GAIS system, conditional aggregation domain–furin cleavage sequence–SIA fusion protein encoded by intramuscularly delivered...
Bo Peng, Lin Sun, Yan Shang, Yajuan Zhang, Xiwen Gao, Ling Ye, Meiling Jin, Wei He, Zhijun Jie, Chunling Du, Lei Zhou, Yang Liu, Xiaolian Song, Juan Fengying Yi Gong, Yuheng Shi, Wuping Bao, Haihua Chen, Jin Wang, Chijun Wen, Weihao Li, Dandan Zhao, Gang Xin Tang
Immune check inhibitors (ICIs) have moderate response rates (~20%–30%) in some malignancies clinically, and, when used combination with other immunotherapeutic strategies such as DNA tumor vaccines, there is evidence to suggest that they could optimize the efficacy of cancer treatment. In this study, we validated intramuscular injection plasmid (pDNA) encoding OVA combined pDNA α-PD-1 (abbreviated following treatment groups) may enhance therapeutic by means situ gene delivery and enhanced...