A5058763832- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- Cellular Mechanics and Interactions
- Mesenchymal stem cell research
- Connective tissue disorders research
- Bee Products Chemical Analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Hippo pathway signaling and YAP/TAZ
- Tendon Structure and Treatment
- Facial Trauma and Fracture Management
- 3D Printing in Biomedical Research
- CAR-T cell therapy research
- Osteoarthritis Treatment and Mechanisms
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Tissue Engineering and Regenerative Medicine
- Bone Metabolism and Diseases
- Molecular Biology Techniques and Applications
- Hemostasis and retained surgical items
- Orthopaedic implants and arthroplasty
- Peptidase Inhibition and Analysis
- Orthodontics and Dentofacial Orthopedics
- Bone and Dental Protein Studies
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
University of Illinois Urbana-Champaign
2018-2024
Urbana University
2020-2021
Center for Genomic Science
2020
University of Southern California
2018
Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen.
Glioblastoma (GBM) is a common and highly lethal type of primary brain tumor in adults. Therapeutic failure partly attributed to fraction Stem Cells (GSCs) that show high levels heterogeneity plasticity. GSCs exist transcriptional gradient between two states: Developmental (Dev) Injury Response (IR) which IR-GSCs exhibit more invasive behaviors. While previous studies have identified fitness genes GSCs, the required establish maintain Dev IR states remain poorly defined. To identify...
Abstract The ability of the extracellular matrix (ECM) to instruct progenitor cell differentiation has generated excitement for development materials‐based regenerative solutions. Described a nanoparticulate mineralized collagen glycosaminoglycan (MC‐GAG) material capable inducing in vivo skull regeneration without exogenous growth factors or ex cell‐priming is described previously. Here, contribution titrating stiffness osteogenicity evaluated by comparing noncrosslinked (NX‐MC) and...
We report the freeform printing of vessel structures and tumor aggregates within a granular suspension cells gelatin methacrylate microgels for modelling cancer progression metastasis.
Contemporary tissue engineering efforts often seek to use mesenchymal stem cells (MSCs) due their potential differentiate various tissue-specific and generate a pro-regenerative secretome. While MSC differentiation therapeutic can differ as function of matrix environment, it may also be widely influenced donor-to-donor variability. Further, effects passage number donor sex further convolute the identification clinically effective MSC-mediated regeneration technologies. We report adapt...
Abstract Contemporary tissue engineering efforts often seek to use mesenchymal stem cells (MSCs) due their multi‐potent potential and ability generate a pro‐regenerative secretome. While many have reported the influence of matrix environment on MSC osteogenic response, few investigated effects donor sex. Here, well‐defined mineralized collagen scaffold is used study passage number donor‐reported sex proliferation potential. A library bone marrow adipose tissue‐derived from eight donors...
Trauma induced injuries of the mouth, jaw, face, and related structures present unique clinical challenges due to their large size complex geometry.
The cancer-associated protein Anterior Gradient 2 (AGR2) has been described, predominantly in adenocarcinomas. Increased levels of extracellular AGR2 (eAGR2) have correlated with poor prognosis cancer patients, making it a potential biomarker. Additionally, neutralizing antibodies showed preclinical effectiveness murine models suggesting eAGR2 may be therapeutic target. We set out to identify peptide by mRNA display that would serve as theranostic tool targeting AGR2. This method enables the...
Abstract The ability of the extracellular matrix (ECM) to instruct progenitor cell differentiation has generated excitement for development materials-based regenerative solutions. We previously described a nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) material capable inducing in vivo skull regeneration approaching 60% biomechanical properties native calvarium without exogenous growth factors or ex cell-priming, suggesting promise as first-generation regeneration. Here, we...
Abstract Osteosarcoma (OS) is the most common primary tumor of bone and characterized by rapid remodeling accompanied structural mechanical heterogeneity across tumor. Chemoresistance recurrence OS can be attributed to a subpopulation cells known as cancer stem-like (OS-CSCs). It hypothesized that niches possessing distinct properties could harboring different cell populations, certain might more conducive for OS-CSCs formation maintenance. To evaluate presence OS-CSCs, mineralized collagen...
ABSTRACT Trauma induced injuries of the mouth, jaw, face, and related structures present unique clinical challenges due to their large size complex geometry. Growth factor signaling coordinates behavior multiple cell types following an injury, effective coordination growth availability within a biomaterial can be critical for accelerating bone healing. Mineralized collagen scaffolds are class degradable whose biophysical compositional parameters adjusted facilitate invasion tissue...
Abstract The tissue microenvironment is comprised of a complex assortment multiple cell types, matrices, membranes and vessel structures. Emulating this often hierarchical organization in vitro has proved considerable challenge, typically involving segregation different types using layer-by-layer printing or lithographically patterned microfluidic devices. Bioprinting granular materials new methodology with tremendous potential for fabrication. Here, we demonstrate the first example tumor...
ABSTRACT The design of biomaterials to regenerate bone is likely increasingly require modifications that reduce bacterial attachment and biofilm formation as infection during wound regeneration can significantly impede tissue repair typically requires surgical intervention restart the healing process. Here, we investigate ability a mineralized collagen biomaterial natively resist well how addition manuka honey affects colonization mesenchymal stem cell osteogenesis. We incorporate into these...