A5030836933- Microtubule and mitosis dynamics
- Cellular Mechanics and Interactions
- Gold and Silver Nanoparticles Synthesis and Applications
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Immune cells in cancer
- nanoparticles nucleation surface interactions
- Copper-based nanomaterials and applications
- Ubiquitin and proteasome pathways
- Nanoparticle-Based Drug Delivery
- Neuroscience and Neuropharmacology Research
- 3D Printing in Biomedical Research
University of Toronto
2022-2024
Glioblastoma (GBM) is a common and highly lethal type of primary brain tumor in adults. Therapeutic failure partly attributed to fraction Stem Cells (GSCs) that show high levels heterogeneity plasticity. GSCs exist transcriptional gradient between two states: Developmental (Dev) Injury Response (IR) which IR-GSCs exhibit more invasive behaviors. While previous studies have identified fitness genes GSCs, the required establish maintain Dev IR states remain poorly defined. To identify...
Abstract Engineered biomaterial scaffolds are becoming more prominent in research laboratories to study drug efficacy for oncological applications vitro, but do they have a place pharmaceutical screening pipelines? The low of cancer drugs phase II/III clinical trials suggests that there critical mechanisms not properly accounted the pre‐clinical evaluation candidates. Immune cells associated with tumor may account some these failures given recent successes immunotherapies; however, few...
Glioblastoma stem cells (GSCs) play an important role in the invasive nature of glioblastoma (GBM); yet, mechanisms driving this behavior are poorly understood. To recapitulate tumor invasion vitro, we developed a GBM tumor-mimetic hydrogel using extracellular matrix components upregulated patients. We show that our facilitates infiltration subset patient-derived GSCs, differentiating samples based on phenotypic invasion. Invasive GSCs enriched for injury-responsive pathways while...
Crystals are known to grow nonclassically or via four classical modes (the layer-by-layer, dislocation-driven, dendritic, and normal modes, which generally involve minimal interfacet surface diffusion). The field of nanoscience considers this framework interpret how nanocrystals grow; yet, the growth many anisotropic remains enigmatic, suggesting that may be incomplete. Here, we study solution-phase pentatwinned Au nanorods without Br, Ag, surfactants. Lower supersaturation conditions...