A5055024652- Periodontal Regeneration and Treatments
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Bone and Dental Protein Studies
- Tissue Engineering and Regenerative Medicine
- Proteoglycans and glycosaminoglycans research
- Advanced biosensing and bioanalysis techniques
- Tendon Structure and Treatment
- RNA Interference and Gene Delivery
- Bee Products Chemical Analysis
- Wnt/β-catenin signaling in development and cancer
- Graphene and Nanomaterials Applications
- Cancer-related gene regulation
- Plasmonic and Surface Plasmon Research
- Bone Metabolism and Diseases
- Hippo pathway signaling and YAP/TAZ
- Electrospun Nanofibers in Biomedical Applications
- Connective tissue disorders research
- Cellular Mechanics and Interactions
- Collagen: Extraction and Characterization
- Advanced Nanomaterials in Catalysis
- Quantum Dots Synthesis And Properties
- Cell Adhesion Molecules Research
Rice University
2025
University of Illinois Urbana-Champaign
2021-2024
The Ohio State University
2016-2021
Molecular self-assembly has become a well-established technique to design complex nanostructures and hierarchical mesoscale assemblies. The typical approach is binding complementarity into nucleotide or amino acid sequences achieve the desired final geometry. However, with an increasing interest in dynamic nanodevices, need structures motion necessitated development of multi-component structures. While this been achieved through assembly similar structural units, here we focus on...
Craniomaxillofacial (CMF) bone injuries represent particularly challenging environments for regenerative healing due to their large sizes, irregular and unique defect shapes, angiogenic requirements, mechanical stabilization needs. These defects also exhibit a heightened inflammatory environment that can complicate the process. This study investigates influence of initial stance human mesenchymal stem cells (hMSCs) on key osteogenic, angiogenic, immunomodulatory criteria when cultured in...
Contemporary tissue engineering efforts often seek to use mesenchymal stem cells (MSCs) due their potential differentiate various tissue-specific and generate a pro-regenerative secretome. While MSC differentiation therapeutic can differ as function of matrix environment, it may also be widely influenced donor-to-donor variability. Further, effects passage number donor sex further convolute the identification clinically effective MSC-mediated regeneration technologies. We report adapt...
Abstract Contemporary tissue engineering efforts often seek to use mesenchymal stem cells (MSCs) due their multi‐potent potential and ability generate a pro‐regenerative secretome. While many have reported the influence of matrix environment on MSC osteogenic response, few investigated effects donor sex. Here, well‐defined mineralized collagen scaffold is used study passage number donor‐reported sex proliferation potential. A library bone marrow adipose tissue‐derived from eight donors...
Targeted refinement of regenerative materials requires mechanistic understanding cell-material interactions. The nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) scaffold is shown to promote skull regeneration in vivo without additive exogenous growth factors or progenitor cells, suggesting potential for clinical translation. This work evaluates modulation MC-GAG stiffness on canonical Wnt (cWnt) signaling. Primary human bone marrow-derived mesenchymal stem cells (hMSCs) are...
The temporospatial equilibrium of phosphate contributes to physiological bone development and fracture healing, yet optimal control content has not been explored in skeletal regenerative materials. Nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) is a synthetic, tunable material that promotes vivo skull regeneration. In this work, the effects MC-GAG on surrounding microenvironment osteoprogenitor differentiation are investigated. This study finds exhibits temporal relationship...
Craniomaxillofacial (CMF) bone injuries present a major surgical challenge and cannot heal naturally due to their large size complex topography. We are developing mineralized collagen scaffold that mimics extracellular matrix (ECM) features of bone. These scaffolds induce in vitro human mesenchymal stem cell (hMSC) osteogenic differentiation vivo formation without the need for exogenous supplements. Here, we seek enhance pro-regenerative potential via inclusion placental-derived products...
Simultaneous self-assembly of two distinct DNA origami nanostructures folded with the same scaffold strand was achieved in a single pot. Relative yields were tuned by adjusting concentrations competing strands, correlating well folding kinetics individual structures. These results can faciliate efficient fabrication multi-structure systems and materials.
Abstract Precision material design directed by cell biological processes represents a frontier in developing clinically translatable regenerative technologies. While understanding cell‐material interactions on multipotent progenitor cells yields insights target tissue differentiation, equally if not more important is the quantification of indirect multicellular interactions. In this work, relationship two properties, phosphate content and stiffness, nanoparticulate mineralized collagen...
PURPOSE: Fabrication of biomaterials that emulate properties tissue-specific extracellular matrix (ECM) and consequently regulate progenitor cell fate are particular interest in the development a "materials-only" regenerative application for osseous defects. Nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) is synthetic material promotes vitro osteogenic differentiation vivo skull regeneration without exogenous growth factors ex-vivo seeding. The mineral content MC-GAG critical...
ABSTRACT The design of biomaterials to regenerate bone is likely increasingly require modifications that reduce bacterial attachment and biofilm formation as infection during wound regeneration can significantly impede tissue repair typically requires surgical intervention restart the healing process. Here, we investigate ability a mineralized collagen biomaterial natively resist well how addition manuka honey affects colonization mesenchymal stem cell osteogenesis. We incorporate into these...
ABSTRACT Craniomaxillofacial (CMF) bone injuries present a major surgical challenge and cannot heal naturally due to their large size complex topography. Approximately 26% of injured Iraq war veterans sustained CMF in the form blast wounds, 0.1% births involve defects like cleft palate. We previously developed class mineralized collagen scaffolds designed mimic native extracellular matrix (ECM) features bone. These induce vitro human mesenchymal stem cell (hMSC) osteogenic differentiation...
Craniomaxillofacial (CMF) bone injuries present a major surgical challenge and cannot heal naturally due to their large size complex topography. Approximately 26% of injured Iraq war veterans sustained CMF in the form blast wounds, 0.1% births involve defects like cleft palate. We previously developed class mineralized collagen scaffolds designed mimic native extracellular matrix (ECM) features bone. These induce vitro human mesenchymal stem cell (hMSC) osteogenic differentiation vivo...
ABSTRACT Effective design of biomaterials to aid regenerative repair craniomaxillofacial (CMF) bone defects requires approaches that modulate the complex interplay between exogenously added progenitor cells and in wound microenvironment, such as osteoblasts, osteoclasts, endothelial cells, immune cells. We are exploring role glycosaminoglycan (GAG) content a class mineralized collagen scaffolds recently shown promote osteogenesis healing craniofacial defects. previously showed incorporating...
Abstract Targeted refinement of regenerative materials requires mechanistic understanding cell-material interactions. The nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) scaffold is a porous biomaterial that promotes healing calvaria defects in vivo without addition exogenous growth factors or progenitor cells, suggesting its potential as an off-the-shelf implant for reconstructing skull defects. In this work, we evaluate the relationship between material stiffness, tunable...