A5019240728- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Nuclear physics research studies
- High-Energy Particle Collisions Research
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Nuclear Physics and Applications
- Superconducting Materials and Applications
- Advanced NMR Techniques and Applications
- Quantum, superfluid, helium dynamics
- Particle Accelerators and Free-Electron Lasers
- Atomic and Molecular Physics
- Particle Detector Development and Performance
- Atomic and Subatomic Physics Research
- Cancer Cells and Metastasis
- Electrospun Nanofibers in Biomedical Applications
- Advanced Chemical Physics Studies
- Dark Matter and Cosmic Phenomena
- Silicon Nanostructures and Photoluminescence
- Particle accelerators and beam dynamics
- Nanowire Synthesis and Applications
- Bone Tissue Engineering Materials
- Hydrogels: synthesis, properties, applications
- Advanced biosensing and bioanalysis techniques
- X-ray Spectroscopy and Fluorescence Analysis
UNSW Sydney
2010-2025
Materials Science & Engineering
2019-2025
University of Illinois Urbana-Champaign
2012-2021
Cancer Institute of New South Wales
2021
Forschungszentrum Jülich
2008-2019
New South Wales Department of Health
2019
Urbana University
2015-2016
Center for Genomic Science
2014
University of Illinois System
1991-2014
Northwestern University
2012
Significant efforts have been directed to understanding the factors that influence lineage commitment of stem cells. This paper demonstrates cell shape, independent soluble factors, has a strong on differentiation human mesenchymal cells (MSCs) from bone marrow. When exposed competing signals, cultured in rectangles with increasing aspect ratio and shapes pentagonal symmetry but different subcellular curvature—and each occupying same area—display adipogenesis osteogenesis profiles. The...
Researchers report advances in materials and designs for skin-integrated devices capable of measuring acoustic signatures.
Abstract Silk fibroin hydrogels are extensively explored for tissue engineering and regenerative medicine as an artificial extracellular matrix (ECM) that can support growth. However, the nanometer pore size of limits adequate cell, tissue, vascular infiltration. Microgel scaffolds emerging class microporous biomaterials formed by annealing small microscale (microgels) into a 3D construct. In this work, silk microgels generated using microfluidic device allows tuning microgel diameter...
Here, we report on the first part of a two-part experimental series to elucidate spatiotemporal cytoskeletal remodeling, which underpins evolution stem cell shape and fate, emergence tissue structure function. In Part I these studies, develop protocols stabilize microtubules exogenously using paclitaxel (PAX) in standardized model murine embryonic line (C3H/10T1/2) maximize comparability with previously published studies. We then probe native microtubule-stabilized cells' capacity adapt...
Stem cells adapt to their local mechanical environment by rearranging cytoskeleton, which underpins the evolution of shape and fate as well emergence tissue structure function. Here, in second part a two-part experimental series, we aimed elucidate spatiotemporal cytoskeletal remodeling resulting changes morphology properties nuclei. Akin testing most basic living adapting unit life, i.e., cell, situ model templates, probed native microtubule-stabilized (via Paclitaxel, PAX, exposure) stem...
In this article, we report the functionalization of alkyne-terminated alkyl monolayers on Si(100) using "click" chemistry, specifically, Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction azides with surface-bound alkynes. Covalently immobilized, structurally well-defined acetylene-terminated organic were prepared from a commercially available terminal diyne species one-step hydrosilylation procedure. Subsequent derivatization in aqueous environments representative azide via...
A data anomaly was observed that affected the uniformity and reproducibility of fluorescent signal across DNA microarrays. Results from experimental sets designed to identify potential causes (from microarray production array scanning) indicated linked a batch process; further work allowed us localize effect posthybridization stringency washes. Ozone levels were monitored highly correlated with effect. Controlled exposures microarrays ozone confirmed this factor as root cause, we present...
Sticky situation: The differentiation of mesenchymal stem cells can be influenced by the affinity and density an immobilized ligand for integrin receptors. Cells adherent to monolayers that present high-affinity, cyclic-RGD peptide (left) show increased expression osteogenic markers, while on presenting lower-affinity, linear-RGD (right) express early markers myogenesis at a high neurogenesis low ligand. Detailed facts importance specialist readers are published as "Supporting Information"....
Significance The health benefits of ω-3 fatty acids are mediated, in part, through metabolic conversion to bioactive epoxides. Here we detail the discovery and initial characterization naturally occurring ω-3–derived endocannabinoid epoxides that formed via enzymatic oxidation endocannabinoids by cytochrome P450s. These dual functional anti-inflammatory vasodilatory reciprocally modulate platelet aggregation. By virtue their physiological properties, they expected play important roles...
The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in single step. A range geometric architectures are demonstrated, and the migration segregated tumor cells macrophages explored using drugs that inhibit heterotypic interactions. As service to our authors readers, this journal provides supporting information supplied by authors. Such materials peer reviewed may be re-organized for online delivery,...
The propensity of stem cells to specify and commit a particular lineage program is guided by dynamic biophysical biochemical signals that are temporally regulated. However, most in vitro studies rely on "snapshots" cell state under static conditions. Here we asked whether changing the aspects substrate could modulate degree mesenchymal (MSC) specification. We chose explore two diverse differentiation outcomes: MSC osteogenesis trans-differentiation neuron-like cells. MSCs were cultured soft...
The secretion of trophic factors that promote angiogenesis from mesenchymal stem cells (MSCs) is a promising cell-based therapeutic treatment. However, clinical efficacy has proved variable, likely on account ill-defined cell delivery formulations and the inherent complexity cellular secretion. Here we show how controlling mechanical properties protein composition extracellular matrix (ECM) surrounding MSCs can guide proangiogenic signaling. Conditioned media adherent to polyacrylamide...
Gallium (Ga) compounds, as the source of Ga ions (Ga3+), have been historically used anti-inflammatories. Currently, widely accepted mechanisms anti-inflammatory effects for Ga3+ are rationalized on basis their similarities to ferric (Fe3+), which permits bind with Fe-binding proteins and subsequently disturbs Fe homeostasis in immune cells. Here contrast classic views, our study presents by delivering nanodroplets (GNDs) into lipopolysaccharide-induced macrophages exploring processes. The...
The hadronic reaction pp→Σ+K0p was measured exclusively at a beam momentum of 2.95GeV/c using the TOF detector COSY storage ring. A narrow peak observed in invariant mass spectrum K0p-subsystem 1530±5MeV/c2 with significance 4–6 standard deviations, depending on background assumptions. upper limit 18±4MeV/c2 (FWHM) for its width is given by experimental resolution. corresponding total cross section estimated to be about 0.4±0.1(stat)±0.1(syst) μb. Since resonance this subsystem must have...