A5101895988- Stellar, planetary, and galactic studies
- Astronomy and Astrophysical Research
- Quantum Dots Synthesis And Properties
- Advanced biosensing and bioanalysis techniques
- Astrophysics and Star Formation Studies
- Astronomical Observations and Instrumentation
- Photocathodes and Microchannel Plates
- Nanocluster Synthesis and Applications
- Astro and Planetary Science
- Advanced Biosensing Techniques and Applications
- Galaxies: Formation, Evolution, Phenomena
- Gamma-ray bursts and supernovae
- Solar and Space Plasma Dynamics
- Atmospheric Ozone and Climate
- Adaptive optics and wavefront sensing
- Chalcogenide Semiconductor Thin Films
- Nanoplatforms for cancer theranostics
- Biosensors and Analytical Detection
- Astrophysical Phenomena and Observations
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Neuroscience and Neural Engineering
- Calibration and Measurement Techniques
- Carbon and Quantum Dots Applications
- Photoreceptor and optogenetics research
University of Illinois Urbana-Champaign
2015-2024
Illinois College
2014-2024
Fayetteville State University
2024
Emory University
2006-2023
Urbana University
2022-2023
University of Illinois System
2019-2023
University of Michigan–Ann Arbor
2020
Institute of Micro and Nanotechnology
2020
University of Kentucky HealthCare
2017
National Cancer Registration Service
2017
Semiconductor nanocrystals are tiny light-emitting particles on the nanometer scale. Researchers have studied these intensely and developed them for broad applications in solar energy conversion, optoelectronic devices, molecular cellular imaging, ultrasensitive detection. A major feature of semiconductor is quantum confinement effect, which leads to spatial enclosure electronic charge carriers within nanocrystal. Because this researchers can use size shape “artificial atoms” widely...
A number of procedures are currently available to encapsulate and solubilize hydrophobic semiconductor Quantum Dots (QDs) for biological applications. Most these based on the use small-molecule coordinating ligands, amphiphilic polymers, or lipids. However, it is still not clear how different surface coating molecules affect optical, colloidal, chemical properties solubilized QDs. Here we report a systematic study examine effects chemistry hydrodynamic size, fluorescence quantum yield,...
Nanoparticles have recently emerged as a promising class of carriers for the co-delivery multiple drugs. Combination therapies small-molecule drugs are common in clinical practice, and it is anticipated that packaging into single macromolecular will enable drug release precisely balanced ratios rates selectively targeted tissues cells. This vast level pharmacological control intriguing, especially from perspective tailoring personalized treatments with maximized therapeutic synergy...
We report quenching and chemical degradation of polymer-coated quantum dots by reactive oxygen species (ROS), a group oxygen-containing molecules that are produced cellular metabolism involved in both normal physiological disease processes such as oxidative signaling, cancer, atherosclerosis. A major new finding is hypochlorous acid (HOCl) its neutral form especially potent degrading encapsulated QDs, due to small size, charge, long half-life, fast reaction kinetics under physiologic...
While nanoscale quantum emitters are effective tags for measuring biomolecular interactions, their utilities applications that demand single-unit observations limited by the requirements large numerical aperture (NA) objectives, fluorescence intermittency, and poor photon collection efficiency resulted from omnidirectional emission. Here, we report a nearly 3000-fold signal enhancement achieved through multiplicative effects of enhanced excitation, highly directional extraction, improvement,...
Macrophage plasticity is critical for normal tissue repair following injury. In pathologic states such as diabetes, macrophage impaired, and macrophages remain in a persistent proinflammatory state; however, the reasons this are unknown. Here, using single-cell RNA sequencing of human diabetic wounds, we identified increased JMJD3 wound macrophages, resulting inflammatory gene expression. Mechanistically, report that healing, directs early macrophage-mediated inflammation via JAK1,3/STAT3...
We report a new strategy to minimize the hydrodynamic size of quantum dots (QDs) and overcome their colloidal stability photobleaching problems based on use multifunctional multidentate polymer ligands. A novel finding is that balanced composition thiol (-SH) amine (-NH 2) coordinating groups grafted linear chain leads highly compact nanocrystals with exceptional stability, strong resistance photobleaching, high fluorescence yields. In contrast standing brushlike conformation PEGylated...
We report a new strategy based on mercury cation exchange in nonpolar solvents to prepare bright and compact alloyed quantum dots (QDs) (HgxCd1−xE, where E = Te, Se, or S) with equalized particle size broadly tunable absorption fluorescence emission the near-infrared. The main rationale is that cubic CdE HgE have nearly identical lattice constants but very different band gap energies electron/hole masses. Thus, replacement of Cd2+ by Hg2+ CdTe nanocrystals does not change size, it greatly...
The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in single step. A range geometric architectures are demonstrated, and the migration segregated tumor cells macrophages explored using drugs that inhibit heterotypic interactions. As service to our authors readers, this journal provides supporting information supplied by authors. Such materials peer reviewed may be re-organized for online delivery,...
Abstract As molecular labels for cells and tissues, fluorescent probes have shaped our understanding of biological structures processes. However, their capacity quantitative analysis is limited because photon emission rates from multicolour fluorophores are dissimilar, unstable often unpredictable, which obscures correlations between measured fluorescence concentration. Here we introduce a new class light-emitting quantum dots with tunable equalized brightness across broad range colours. The...
Obesity leads to an increased risk for type 2 diabetes, heart disease, stroke, and cancer. The causal link between obesity these pathologies has recently been identified as chronic low-grade systemic inflammation initiated by pro-inflammatory macrophages in visceral adipose tissue. Current medications based on small-molecule drugs yield significant off-target side effects with long-term use, therefore there is a major need targeted therapies. Here we report that nanoscale polysaccharides...
B-Type natriuretic peptide (BNP) is released from the left ventricle of heart into circulation in response to ventricular stretching and volume overload. Increased BNP concentrations are associated with failure (HF).We evaluated analytical clinical performance Bayer ADVIA Centaur assay. Studies included precision, correlation (against Shionogi ShionoRIA Biosite Triage assays), results for blood collected plastic tubes containing EDTA vs other collection tubes, high-dose hook effect,...