Wei-Ling Chen

ORCID: 0000-0002-2261-4519
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About
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Research Areas
  • Nanoplatforms for cancer theranostics
  • Chemokine receptors and signaling
  • Advanced Biosensing Techniques and Applications
  • Asthma and respiratory diseases
  • Immune Cell Function and Interaction
  • Dermatology and Skin Diseases
  • Photodynamic Therapy Research Studies
  • Advanced Nanomaterials in Catalysis
  • Immunotherapy and Immune Responses
  • Urticaria and Related Conditions
  • Calcium signaling and nucleotide metabolism
  • Breast Cancer Treatment Studies
  • Medical Imaging Techniques and Applications
  • Autophagy in Disease and Therapy
  • CAR-T cell therapy research
  • Histone Deacetylase Inhibitors Research
  • Advanced biosensing and bioanalysis techniques

Xiamen University
2023-2025

Immunologie-Zentrum Zürich
2017

Technical University of Munich
2017

Toronto General Hospital
2013

Clinical features and basophil activation levels correlate with serum autoreactivity allergen sensitivity in patients chronic spontaneous urticaria (CSU).To explore the relationship of expression patterns plasma T-helper cell (Th) 1-, Th2-, Th17- Th22-related cytokines CSU.Twenty related were measured analysed 60 CSU, 15 acute urticaria, 10 atopic dermatitis (AD) healthy persons, respectively. Autologous skin testing (ASST) prick (SPT) performed to detect allergy sensitivity, The...

10.1111/jdv.14541 article EN Journal of the European Academy of Dermatology and Venereology 2017-08-28

Intraoperative surgical margin assessment remains a challenge during breast-conserving surgery. Here, we report combined strategy of immuno–positron emission tomography (PET) for preoperative detection breast cancer and guided margins in surgery through second near-infrared (NIR-II) fluorescence imaging trophoblastic cell surface antigen 2 (TROP2). We demonstrated that the intensity PET signals tumors was nearly five times higher than normal tissue with zirconium-89 tracer conjugated to...

10.1126/scitranslmed.ado2461 article EN Science Translational Medicine 2024-10-16

Abstract Breast‐conserving surgery (BCS) has become the standard care for early‐stage breast cancer. The accurate assessment of tumor margins is urgently required BCS because positive resection often lead to local recurrence. To address this clinical dilemma, a Hf(IV)‐coordinated NIR‐II fluorescence “turn‐on” nanoprobe based on clinically approved fluorescent dye indocyanine green (ICG) intraoperative visualization developed. Notably, ICG can be efficiently quenched by Hf(IV) and...

10.1002/advs.202413385 article EN cc-by Advanced Science 2025-02-14

Sentinel lymph node (SLN) biopsy plays a critical role in axillary staging of breast cancer. However, traditional SLN mapping does not accurately discern the presence or absence metastatic disease. Detection metastasis largely hinges on examination frozen sections paraffin-embedded tissues post-SLN biopsy. To improve detection metastasis, we developed second near-infrared (NIR-II) vivo fluorescence imaging system, pairing erbium-based rare-earth nanoparticles (ErNP) with bright...

10.1158/0008-5472.can-22-3432 article EN cc-by-nc-nd Cancer Research 2023-08-04

<div>Abstract<p>Sentinel lymph node (SLN) biopsy plays a critical role in axillary staging of breast cancer. However, traditional SLN mapping does not accurately discern the presence or absence metastatic disease. Detection metastasis largely hinges on examination frozen sections paraffin-embedded tissues post-SLN biopsy. To improve detection metastasis, we developed second near-infrared (NIR-II) vivo fluorescence imaging system, pairing erbium-based rare-earth nanoparticles...

10.1158/0008-5472.c.6879354.v2 preprint EN 2024-09-16

<div>Abstract<p>Sentinel lymph node (SLN) biopsy plays a critical role in axillary staging of breast cancer. However, traditional SLN mapping does not accurately discern the presence or absence metastatic disease. Detection metastasis largely hinges on examination frozen sections paraffin-embedded tissues post-SLN biopsy. To improve detection metastasis, we developed second near-infrared (NIR-II) vivo fluorescence imaging system, pairing erbium-based rare-earth nanoparticles...

10.1158/0008-5472.c.6879354 preprint EN 2023-10-13

<div>Abstract<p>Sentinel lymph node (SLN) biopsy plays a critical role in axillary staging of breast cancer. However, traditional SLN mapping does not accurately discern the presence or absence metastatic disease. Detection metastasis largely hinges on examination frozen sections paraffin-embedded tissues post-SLN biopsy. To improve detection metastasis, we developed second near-infrared (NIR-II) <i>in vivo</i> fluorescence imaging system, pairing erbium-based...

10.1158/0008-5472.c.6879354.v1 preprint EN 2023-10-13
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