A5089379376- Nanoplatforms for cancer theranostics
- Bone fractures and treatments
- Foot and Ankle Surgery
- Photodynamic Therapy Research Studies
- Orthopedic Surgery and Rehabilitation
- Musculoskeletal Disorders and Rehabilitation
- Chemokine receptors and signaling
- Pharmacogenetics and Drug Metabolism
- Antibiotic Use and Resistance
- Photoacoustic and Ultrasonic Imaging
- HIV/AIDS drug development and treatment
- Advanced Biosensing Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Total Knee Arthroplasty Outcomes
- Antibiotic Resistance in Bacteria
- Knee injuries and reconstruction techniques
- Orthopaedic implants and arthroplasty
- Tuberculosis Research and Epidemiology
- Tea Polyphenols and Effects
- Dysphagia Assessment and Management
- CAR-T cell therapy research
- Spinal Cord Injury Research
- Nosocomial Infections in ICU
- Nerve injury and regeneration
- Medical Research and Practices
First Affiliated Hospital Zhejiang University
2024
Xiamen University
2021-2024
Ministry of Agriculture and Rural Affairs
2023
Anhui Agricultural University
2023
Second Hospital of Shanxi Medical University
2019-2022
Shanxi Medical University
2019-2022
Peking Union Medical College Hospital
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
University of Technology Sydney
2020
Intraoperative surgical margin assessment remains a challenge during breast-conserving surgery. Here, we report combined strategy of immuno–positron emission tomography (PET) for preoperative detection breast cancer and guided margins in surgery through second near-infrared (NIR-II) fluorescence imaging trophoblastic cell surface antigen 2 (TROP2). We demonstrated that the intensity PET signals tumors was nearly five times higher than normal tissue with zirconium-89 tracer conjugated to...
Obtaining tumour-free margins is critical for avoiding re-excision and reducing local recurrence following breast-conserving surgery; however, it remains challenging. Imaging-guided surgery provides precise detection of residual lesions assists surgical resection. Herein, we described water-soluble melanin nanoparticles (MNPs) conjugated with cyclic Arg-Gly-Asp (cRGD) peptides breast cancer photoacoustic imaging (PAI) navigation.The cRGD-MNPs were synthesised characterized morphology,...
Sentinel lymph node (SLN) biopsy plays a critical role in axillary staging of breast cancer. However, traditional SLN mapping does not accurately discern the presence or absence metastatic disease. Detection metastasis largely hinges on examination frozen sections paraffin-embedded tissues post-SLN biopsy. To improve detection metastasis, we developed second near-infrared (NIR-II) vivo fluorescence imaging system, pairing erbium-based rare-earth nanoparticles (ErNP) with bright...
Background: Durable responses to immune-checkpoint blocking therapy (ICT) targeting programmed cell death protein-1/ligand-1 (PD-1/PD-L1) have improved outcomes for patients with triple negative breast cancer (TNBC). Unfortunately, only 19– 23% of benefit from ICT. Hence, non-invasive strategies evaluating and selecting who will ICT are critical issues TNBC immunotherapy. Methods: We developed a novel nanoparticle-Atezolizumab (NPs-Ate) consisting indocyanine green (ICG),...
<p>All Supplementary Data</p>
<div>Abstract<p>Sentinel lymph node (SLN) biopsy plays a critical role in axillary staging of breast cancer. However, traditional SLN mapping does not accurately discern the presence or absence metastatic disease. Detection metastasis largely hinges on examination frozen sections paraffin-embedded tissues post-SLN biopsy. To improve detection metastasis, we developed second near-infrared (NIR-II) vivo fluorescence imaging system, pairing erbium-based rare-earth nanoparticles...
<p>All Supplementary Data</p>
Abstract Background Management of Rüedi-Allgöwer III or AO/OTA type C3 pilon fracture presents numerous challenges to the orthopaedic surgeon. A joint preservation technique using a large autologous ilium with periosteum in combination internal implant fixation was reported improve outcome reconstruction . Methods Twenty-five patients according Tscherne/Oestern FxCO-I closed and FxOI open fractures classification after received for tibiotalar reduction (ORIF), between March 2015 September...
Objective: To verify the efficacy and safety of daily oral minodronate in postmenopausal women with established osteoporosis. Methods: In this randomized, double-blinded, placebo-controlled trial, 262 were enrolled. Patients randomized to receive 1 mg supplements 500 calcium 200 U vitamin D3 (n=130) or placebo (n=132) D3, for 48 weeks. The primary endpoint was average bone mineral density (BMD) change lumbar vertebrae weeks post-treatment. Secondary outcome measures incidence vertebral...
Abstract Purpose : Obtaining tumour-free margins is critical for avoiding re-excision and 35 reducing local recurrence following breast-conserving surgery (BCS); however, it 36 remains challenging. Imaging-guided provides precise detection of residual 37 lesions assists surgical resection. Herein, we describe water-soluble melanin 38 nanoparticles (MNPs) conjugated with cyclic Arg-Gly-Asp (cRGD) peptides breast 39 cancer photoacoustic imaging (PAI) navigation. 40 Methods cRGD-MNPs was...
Abstract Purpose Accurate evaluation of tumor boundaries in breast-conserving surgery is very important to reduce the second operation patients.Near-infrared fluorescence imaging using molecular agents has shown promise for situ during resection.However, there are effective probes that can be applied clinical trials up now. Here we developed a new technology quickly identify area both vivo and resected breast tissue distinguish boundary. Methods 1. Characterization biosafety probe SG-ICG...
<p>All Supplementary Data</p>
<div>Abstract<p>Sentinel lymph node (SLN) biopsy plays a critical role in axillary staging of breast cancer. However, traditional SLN mapping does not accurately discern the presence or absence metastatic disease. Detection metastasis largely hinges on examination frozen sections paraffin-embedded tissues post-SLN biopsy. To improve detection metastasis, we developed second near-infrared (NIR-II) vivo fluorescence imaging system, pairing erbium-based rare-earth nanoparticles...
<div>Abstract<p>Sentinel lymph node (SLN) biopsy plays a critical role in axillary staging of breast cancer. However, traditional SLN mapping does not accurately discern the presence or absence metastatic disease. Detection metastasis largely hinges on examination frozen sections paraffin-embedded tissues post-SLN biopsy. To improve detection metastasis, we developed second near-infrared (NIR-II) <i>in vivo</i> fluorescence imaging system, pairing erbium-based...
<p>All Supplementary Data</p>