A5066803991- Perovskite Materials and Applications
- CAR-T cell therapy research
- Advanced Battery Technologies Research
- Catalytic Processes in Materials Science
- Nuclear and radioactivity studies
- Graphite, nuclear technology, radiation studies
- Extraction and Separation Processes
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Battery Materials and Technologies
- Engineering Education and Curriculum Development
- Hybrid Renewable Energy Systems
- Musculoskeletal pain and rehabilitation
- Global Energy and Sustainability Research
- Genetics, Bioinformatics, and Biomedical Research
- Recycling and Waste Management Techniques
- Nanotechnology research and applications
- Nanoparticles: synthesis and applications
- solar cell performance optimization
- Advancements in Battery Materials
- Advancements in Semiconductor Devices and Circuit Design
- Green IT and Sustainability
- COVID-19 and healthcare impacts
- Machine Learning in Materials Science
- Silk-based biomaterials and applications
- Solar-Powered Water Purification Methods
Houston Methodist
2024-2025
Centers for Disease Control and Prevention
2020-2025
Methodist Hospital
2024-2025
CACI International (United States)
2025
Northwestern University
2024
Shreemati Nathibai Damodar Thackersey Women's University
2024
University of Connecticut
2024
Rajarshee Chhatrapati Shahu Maharaj Government Medical College and CPR Hospital Kolhapur
2022-2023
Khyber Medical College
2023
Institute of Medical Sciences
2023
Successful tumor eradication by chimeric antigen receptor-expressing (CAR-expressing) T lymphocytes depends on CAR cell persistence and effector function. We hypothesized that CD4+ CD8+ cells may exhibit distinct phenotypes, depending the identity of specific intracellular signaling domains (ICDs) used to generate CAR. First, we demonstrate ICOS ICD dramatically enhanced in vivo CAR-expressing that, turn, increased expressing either CD28- or 4-1BB-based CARs. These data indicate was highly...
A chimeric antigen receptor redirects T cells to treat glioblastoma.
Abstract Objectives: To determine the impact of coronavirus disease 2019 (COVID-19) pandemic on healthcare-associated infection (HAI) incidence in US hospitals, national- and state-level standardized ratios (SIRs) were calculated for each quarter 2020 compared to those from 2019. Methods: Central–line–associated bloodstream infections (CLABSIs), catheter-associated urinary tract (CAUTIs), ventilator-associated events (VAEs), select surgical site infections, Clostridioides difficile...
The success of chimeric antigen receptor (CAR)-mediated immunotherapy in acute lymphoblastic leukemia (ALL) highlights the potential T-cell therapies with directed cytotoxicity against specific tumor antigens. efficacy CAR therapy depends on engraftment and persistence T cells following adoptive transfer. Most protocols for engineering routinely expand
Data from the National Healthcare Safety Network were analyzed to assess impact of COVID-19 on incidence healthcare-associated infections (HAI) during 2021. Standardized infection ratios significantly higher than those prepandemic period, particularly 2021-Q1 and 2021-Q3. The HAI was elevated periods high hospitalizations.
The increasing risk of incidental exposure to nanomaterials has led mounting concerns regarding nanotoxicity. Zinc oxide nanoparticles (ZnO NPs) are produced in large quantities and have come under scrutiny due their capacity cause cytotoxicity vitro potential harm vivo. Recent evidence indicated that ZnO NPs promote autophagy cells; however, the signaling pathways role ion release inducing toxicity remain unclear. In this study, we report immunotoxic primary immortalized immune cells....
Abstract Data reported to the Centers for Disease Control and Prevention’s National Healthcare Safety Network (CDC NHSN) were analyzed understand potential impact of COVID-19 pandemic on central-line–associated bloodstream infections (CLABSIs) in acute-care hospitals. Descriptive analysis standardized infection ratio (SIR) was conducted by location, location type, geographic area, bed size.
Quality water is used for various daily chores like drainage, drinking, sanitation, agricultural, and other industrial applications, thus being the need of hour. Water a dominant raw material in manufacturing pharmaceuticals chemicals; reliable superior sources are needed many processes, including cooling, refining, extraction. The purpose urban wastewater treatment to eliminate contaminants, destroy toxicants, neutralise coarse particles, bacteria increase consistency discharged maintain...
Abstract Objective: Resilience of the healthcare system has been described as ability to absorb, adapt, and respond stress while maintaining provision safe patient care. We quantified impact that stressors associated with COVID-19 pandemic had on safety, measured by central line-associated bloodstream infections (CLABSIs) reported Centers for Disease Control Prevention’s National Healthcare Safety Network. Design: Acute care hospitals were mandated report markers resource availability...
Patients can develop human anti mouse immune responses against CD19- specific CAR T cells (CARTs) due to the use of a murine scFv redirect cells. To mitigate immunogenicity, humanization process FMC63- based binder was undertaken that resulted in (119) when introduced into showed improved activity humanized model. further characterize how binding domains affect CART function, we screened yeast display library identify an array fully CD19 binders. We saw significant differences ability CARs...
Sepsis, life-threatening organ dysfunction secondary to infection, contributes at least 1.7 million adult hospitalizations and 350,000 deaths annually in the United States. Sepsis care is complex, requiring coordination of multiple hospital departments disciplines. programs can coordinate these efforts optimize patient outcomes. The 2022 National Healthcare Safety Network (NHSN) annual survey evaluated prevalence characteristics sepsis acute hospitals. Among 5,221 hospitals, 3,787 (73%)...