A5011417669- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inhalation and Respiratory Drug Delivery
- Pulmonary Hypertension Research and Treatments
- Immune cells in cancer
- Lung Cancer Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Pediatric health and respiratory diseases
- Medical Imaging and Pathology Studies
- Hematological disorders and diagnostics
- Lung Cancer Research Studies
- Vascular Anomalies and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced X-ray and CT Imaging
- Head and Neck Cancer Studies
- Advanced Chemical Sensor Technologies
- Nuclear Physics and Applications
- Insect Pheromone Research and Control
- Spinal Hematomas and Complications
Tokai University
2016-2025
St. Paul's Hospital
2018-2021
University of British Columbia
2018-2021
BC Innovation Council
2019
St. Paul's Hospital
2019
National Defense Medical College Hospital
1993
Hirosaki University
1969
Abstract The classical M1/M2 polarity of macrophages may not be applicable to inflammatory lung diseases including chronic obstructive pulmonary disease (COPD) due the complex microenvironment in lungs and plasticity macrophages. We examined macrophage sub-phenotypes bronchoalveolar lavage (BAL) fluid 25 participants with CD40 (a M1 marker) CD163 M2 marker). Of these, we performed RNA-sequencing on each subtype 10 patients using Illumina NextSeq 500. Approximately 25% did harbor or surface...
Background A subset of COPD patients have high levels eosinophils in the distal airways (“airway eosinophilia”). Objectives To compare gene expression type 2 inflammation airway epithelial brushings with and without eosinophilia to investigate changes after inhaled corticosteroids (ICS). Methods Post-hoc analyses DISARM randomised controlled trial investigated (type 1, 2, 17), IL-13, mast cell signatures at baseline 12-week ICS treatment. Gene were generated from RNA sequencing brushings....
Exhaled volatile organic compounds (VOC) are being considered as biomarkers for various lungs diseases, including cancer. However, the accurate measurement of extremely low concentrations VOC in expired air is technically challenging. We evaluated clinical contribution exhaled measured with a new, double cold-trap method diagnosis lung cancer.Breath samples were collected from 116 patients histologically confirmed cancer and 37 healthy volunteers (controls) after inspiration purified air,...
Rationale: Inhaled corticosteroids (ICS) are commonly prescribed with long-acting β2-agonists (LABA) in chronic obstructive pulmonary disease (COPD). To date, the effects of ICS therapy on airway microbiome COPD unknown. Objectives: determine ICS/LABA patients COPD. Methods: Clinically stable were enrolled into a 4-week run-in period during which was discontinued and all participants placed formoterol (Form) 12 μg twice daily (BID). The then randomized to budesonide/formoterol (Bud + Form;...
Lung macrophages are the key immune effector cells in pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). Several studies have shown an increase their numbers bronchoalveolar lavage fluid (BAL) subjects with COPD compared to controls, suggesting a pathogenic role disease initiation and progression. Although reduced lung macrophage phagocytic ability has been previously COPD, relationship between macrophages’ phenotypic characteristics functional properties is still unclear. (1)...
Abstract Background People with human immunodeficiency virus (PWH) have an increased risk of developing chronic obstructive pulmonary disease (COPD). Methods We phenotyped lung macrophages in 4 subgroups—M1 (CD40+CD163−), M2 (CD40−CD163+), double positives (CD40+CD163+), and negatives (CD40−CD163−)—and we determined their phagocytic capacity PWH without COPD. Results COPD more double-negative (84.1%) versus (54.3%) controls (23.9%) (P=.004) reduced phagocytosis (P=.012). Double-negative had...
Various volatile organic compounds (VOCs) are known to be toxic. Although exhaled VOC patterns change in obstructive sleep apnea (OSA) patients, individual profiles not fully determined. The primary outcome was characterizations; secondary outcomes included their relationships with and clinical parameters OSA patients. We prospectively examined 32 patients an apnea-hypopnea index (AHI) ≥ 15 by full polysomnography, 33 age- sex-matched controls without obvious symptoms. Nine severe were...
Although development of immune checkpoint inhibitors and various molecular target agents has extended overall survival time (OS) in advanced non-small cell lung cancer (NSCLC), a complete cure remains rare. We aimed to identify features treatment modalities remission (CR) cases stages III IV NSCLC by analyzing long-term survivors whose OS exceeded 3 years. From our hospital database, 1,699 patients, registered as between 1st Mar 2004 30th Apr 2011, were retrospectively examined. Stage or...
A 79-year-old woman presented with unexplained hypoxia that became exacerbated by an upright posture (platypnea-orthodeoxia syndrome). 99mTc-macroaggregated albumin pulmonary perfusion scan revealed a right to left shunt of 25.5% in the supine position and 32.3% sitting position. dynamic CT transoesophageal echocardiogram confirmed presence across atrial septal defect (ASD). percutaneous transcatheter closure significantly improved patient's blood oxygenation levels when she was An ASD...
A 64-year-old man presented with diplopia, muscle weakness, a pulmonary nodule and mediastinal widening on chest radiograph. He was diagnosed clinical stage IIIA (T2aN2M0) lung cancer. His neurological symptoms worsened following the initiation of thoracic radiation therapy (60 Gy) chemotherapy. diagnosis myasthenia gravis (MG) confirmed repetitive nerve stimulation test that showed waning pattern, positive edrophonium test, although neither anti-acetylcholine receptor antibodies nor...
Alveolar barrier dysfunction is one of the major pathophysiological changes in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). In ALI/ARDS, tumor necrosis factor-alpha (TNFα) disrupts barriers alveolar epithelium and endothelium. Glucocorticoids (GCs) exert anti-inflammatory effects ameliorate pulmonary edema ALI/ARDS. However, involvement GCs restoration epithelial has not been extensively studied. Here, we elucidated that dexamethasone (Dex) restored TNFα-induced vitro...
Effects of systemic corticosteroids on blood gene expression are largely unknown. This study determined signature associated with short-term oral prednisone therapy in patients chronic obstructive pulmonary disease (COPD) and its relationship to 1-year mortality following an acute exacerbation COPD (AECOPD). Gene whole was profiled using the Affymetrix Human 1.1 ST microarray chips from two cohorts: 1) a cohort 37 stable randomly assigned 30 mg/d + standard for 4 days or alone 2) Rapid...
Chronic obstructive pulmonary disease (COPD) mainly develops after long-term exposure to cigarette or biomass fuel smoke, but also occurs in non-smokers with without a history of asthma. We investigated the proportion and clinical characteristics among middle-aged elderly subjects airflow obstruction.We retrospectively analyzed 1,892 aged 40-89 years who underwent routine preoperative spirometry at tertiary university hospital Japan. Airflow obstruction was defined as forced expiratory...
A 44-year-old man developed coronavirus disease 2019 (COVID-19) pneumonia during immunochemotherapy consisting of carboplatin, paclitaxel, and pembrolizumab for non-small cell lung cancer. Low-grade fever, followed by mild hypoxemia, febrile neutropenia, were observed, granulocyte colony-stimulating factor (G-CSF) was administered until the recovery when he a high severe hypotension accompanied consolidation in bilateral lungs. His conditions promptly improved after treatment including...