A5001910203- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Climate Change and Health Impacts
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Neonatal Respiratory Health Research
- Immune cells in cancer
- Energy and Environment Impacts
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Biomarkers in Disease Mechanisms
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Obstructive Sleep Apnea Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Air Quality Monitoring and Forecasting
- Neuroscience of respiration and sleep
- Systemic Sclerosis and Related Diseases
- Respiratory and Cough-Related Research
- Cytokine Signaling Pathways and Interactions
- Chemokine receptors and signaling
- Pesticide Exposure and Toxicity
- Heart Rate Variability and Autonomic Control
- Pulmonary Hypertension Research and Treatments
- Noise Effects and Management
University of British Columbia
2016-2025
St. Paul's Hospital
2008-2024
St. Paul's Hospital
1999-2022
University of British Columbia Hospital
1996-2021
Providence Health Care
2008-2018
St. Paul's Co-educational College
2012
Lung Institute
2008-2010
Health Canada
2002-2009
Nagasaki University
2009
Simon Fraser University
2005
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Background —Glucocorticoid-induced granulocytosis has been attributed to enhanced release of polymorphonuclear leukocytes (PMNs) from bone marrow, delayed apoptosis, and reduced egress PMNs into tissues. This study was designed determine the relative contributions released marrow those entering circulation marginated pool produced by a single dose dexamethasone (2.0 mg/kg) in rabbits. Methods Results —PMN transit through mitotic postmitotic pools rate were measured use thymidine analogue...
Organophosphate insecticides may cause serious poisoning either accidentally or by deliberate ingestion. Toxic symptoms are produced acetylcholine accumulation at cholinergic receptors. Diagnosis is based on history of exposure ingestion, and signs overactivity a decrease in serum pseudocholinesterase levels. Following diagnosis, grading disease severity identify patients with who should receive treatment intensive care using adequate doses anticholinergic drugs. Complications, particularly...
Section:ChooseTop of pageAbstract <<Materials And MethodsResultsDiscussionReferencesCITING ARTICLES
Epidemiologic and animal studies have shown that exposure to particulate matter air pollution (PM) is a risk factor for the development of atherosclerosis. Whether PM-induced lung systemic inflammation involved in this process not clear. We hypothesized PM causes inflammation, which turn leads vascular endothelial dysfunction, key step initiation progression New Zealand White rabbits were exposed 5 days (acute, total dose 8 mg) 4 wk (chronic, 16 either smaller than 10 mum (PM(10)) or saline...
Section:ChooseTop of pageAbstract <<MATERIALS AND METHODSRESULTSDISCUSSIONReferencesCITING ARTICLES
Recombinant human interleukin-6 (IL-6) causes both a thrombocytosis and leukocytosis. The is caused by an accelerating thrombocytopoiesis, but the mechanism of leukocytosis unknown. This study was designed to determine relative contributions marrow stimulation intravascular demargination IL-6 induced neutrophilia. (2 μg/kg), administered intravenously rabbits, biphasic neutrophilia with initial peak at 3 h second 9 h. Using thymidine analog 5′-bromo-2′-deoxyuridine (BrdU) label dividing...
Abstract Background Studies from our laboratory have shown that human alveolar macrophages (AM) and bronchial epithelial cells (HBEC) exposed to ambient particles (PM 10 ) in vitro increase their production of inflammatory mediators supernatants PM -exposed shorten the transit time monocytes through bone marrow promote release into circulation. Methods The present study concerns co-culture AM HBEC (EHC-93) involved monocyte kinetics measured at both mRNA protein levels. experiments were also...
Recent studies have shown that an increased concentration of ambient particulate matter (PM10) is related to decreased pulmonary function and respiratory cardiovascular mortality. The mechanisms responsible for this excess mortality are unknown the relationship between level PM10 circulating leukocyte counts has not been previously investigated. We postulated deposition in peripheral lung stimulates alveolar macrophages (AM), which results polymorphonuclear (PMN) release from bone marrow...
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the leading reason for hospitalization in Canada and a significant financial burden on hospital resources. Identifying factors that influence time patient spends readmission rates will allow better use scarce resources.To determine length stay (LOS) patients with AECOPD an inner-city hospital.Using Providence Health Records, retrospective review admitted to St Paul's Hospital (Vancouver, British Columbia) during winter...