A5102958285- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Heme Oxygenase-1 and Carbon Monoxide
- Lung Cancer Treatments and Mutations
- Respiratory and Cough-Related Research
- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Cystic Fibrosis Research Advances
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Research Studies
- Influenza Virus Research Studies
- Neuroendocrine Tumor Research Advances
- Neutropenia and Cancer Infections
- Eosinophilic Disorders and Syndromes
- Mycobacterium research and diagnosis
- Lymphatic Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
- IgG4-Related and Inflammatory Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Colorectal Cancer Treatments and Studies
New Tokyo Hospital
2018-2024
Yokohama City University
2002-2021
Yokohama City University Medical Center
2012-2018
National Defense Medical College
2004-2017
Wake Forest University
2005
Epidermal growth factor receptor ( EGFR ) tyrosine kinase inhibitors TKI s) are the first‐line treatment for patients with mutant non‐small‐cell lung cancer NSCLC ). However, most become resistant to these drugs, so their disease progresses. Osimertinib, a third‐generation ‐ that can inhibit even when common resistance‐conferring Thr790Met (T790M) mutation is present, promising therapeutic option whose has progressed after treatment. AURA 3 was randomized (2:1), open‐label, phase III study...
The Guidelines for the Management of Cough and Sputum (2019) Japanese Respiratory Society (JRS) were first internationally published guidelines management sputum. However, data used to determine causative diseases bloody sputum hemoptysis in these not obtained Japan. A retrospective analysis was performed using clinical information patients with or who visited department respiratory medicine at a university core hospital Included study 556 (median age, 73 years; age range, 21–98 302 males...
Severe or life-threatening asthma exacerbation is one of the worst outcomes because risk death. To date, few studies have explored potential heterogeneity this condition.To examine clinical characteristics and patients with severe exacerbation.This was a multicentre, prospective study pulse oxygen saturation < 90% who were admitted to 17 institutions across Japan. Cluster analysis performed using variables from patient- physician-orientated structured questionnaires.Analysis data 175...
Abstract The clinically significant actions of oral azithromycin in modifying progressive cystic fibrosis (CF) lung disease have been well documented. In vitro and clinical data suggests that clarithromycin has immunomodulatory properties similar to other 14‐member macrolides, however two previously reported short term, open label trials clairthromycin small numbers patients with CF failed show benefits function or inflammation. We performed an international double blind, cross‐over trial...
Objective The arterial concentration of carboxyhemoglobin (CO-Hb) in subjects with inflammatory pulmonary disease is higher than that healthy individuals. We retrospectively analyzed the relationship between CO-Hb and established markers severity interstitial lung (ILD). Methods was measured newly diagnosed or untreated ILD relationships serum biomarker levels, function, high-resolution CT (HRCT) findings, uptake gallium-67 (67Ga) scintigraphy were evaluated. Results Eighty-one non-smoking...
Camostat mesilate is in widespread clinical use mainly to treat chronic pancreatitis, and drug-induced lung injury has not been previously reported. However, pulmonary infiltration with peripheral blood eosinophilia appeared after taking camostat for ten days. The histological findings showed eosinophilic into the alveolar space interstitum, drug lymphocyte stimulation test of was positive. Both involvements improved two weeks later cessation this drug. To best our knowledge, case first...
Some investigations have revealed an association between depression and physical measurements of COPD patients in North America Europe, but few related studies been performed Asia.In this cross-sectional study, 84 consecutive, stable out-patients with (mean ± SD age 72.0 9.0 y, percent-of-predicted FEV1 46 15%, 15 [17.9%] female) a Japanese community hospital were recruited. "Probable depression" was defined as score ≥ 6 on the short-form Geriatric Depression Scale (SF-GDS). Relationships...
Conflicting views exist at the present regarding influences of a deep saturation dive on liver function in divers. Therefore, we first reevaluated whether (400 msw) induces hepatic disturbance. As result, plasma activities both transaminases (aspartate aminotransferase [AST] and alanine [ALT]) increased significantly, whereas cholinesterase (Ch-E) activity decreased markedly, being highly suggestive dysfunction. Assuming that dysfunction was attributable to oxidative stress, next examined...
Influenza-related pneumonia, referred to as influenza was reported relatively more frequently during a recent pandemic in 2009. The validity of adapting routine pneumonia severity prediction models for various types is unclear.We conducted nationwide survey evaluate among adult patients Japan. Questionnaires were sent physicians working departments respiratory medicine at 2491 hospitals. Both the outcome and severity, using invasive positive pressure ventilation (IPPV) an indicator,...
There are some controversial reports that investigated the usefulness of exhaled nitric oxide (eNO) to predict efficacy inhaled corticosteroids (ICS) in chronic cough patients. Therefore, we retrospectively analysed eNO measurement with portable analyser requirement ICS therapy persistent (defined as lasting for 3 weeks or more) patients Japan and whether it might improve management at primary care practice.We reviewed clinical records adult who had been referred our hospital from 1 June...
Acute fibrinous and organizing pneumonia (AFOP) is a very rare pathological entity of lung injury characterized by intra-alveolar fibrin balls. Hemeoxygenase (HO) -1 cytoprotective enzyme against oxidative stress inflammation. It known to be expressed in the alveolar macrophages healthy adults overexpressed other various cells patients. We experienced two cases subacute form AFOP for these 10 years reviewed clinico-pathological characteristics. The average age was 62 old both were male....
Hemeoxygenase-1 (HO-1) is an essential enzyme in heme catabolism and has been proposed as a biomarker of lung disease prognosis. We modified commercial HO-1 enzyme-linked immunosorbent assay (ELISA) kit to achieve higher sensitivity evaluated if serum could be predict the prognosis acute respiratory distress syndrome (ARDS) patients.Serum samples were collected from 15 healthy volunteers validate ELISA. In 22 patients with ARDS who enrolled, was measured upon diagnosis (D0) at 7 days after...
Radiation pneumonitis is a critical pulmonary toxicity after irradiation of the lung. Macrolides including clarithromycin (CAM) are antibiotics. They also have immunomodulatory properties and used to treat respiratory inflammatory diseases. has similar pathology them. Adverse reactions macrolides few self-limited. We thus administered CAM patients with high-risk factors for radiation pneumonitis, retrospectively investigated whether mitigated following stereotactic body radiotherapy...
Serum hemeoxygenase-1 (HO-1) has been proposed to be a biomarker of lung disease activity and prognosis. The present study aimed at evaluating whether HO-1 could useful marker for predicting prognosis in patients with interstitial pneumonia (IP).Serum levels newly diagnosed or untreated IP were measured hospitalization. We evaluated the relationships between serum other biomarkers, high resolution CT (HRCT) findings, hospital mortality.Twenty-eight IP, including 14 having an acute...
A major cause of death in patients undergoing long-term domiciliary oxygen therapy (LTOT) is lung cancer progression. In our institution, we actively perform stereotactic body radiotherapy (SBRT) on with early-stage non-small-cell LTOT. this study, retrospectively analyzed the treatment efficacy and safety SBRT for T1-3N0M0 who had been prescribed LTOT chronic obstructive pulmonary disease (COPD). total 24 were studied. Their median age was 74 years (range, 63-87 years). The duration from...
No previous study clearly demonstrated the association between absolute neutrophil count (ANC) nadir and monocyte (AMC) among patients undergoing chemotherapy.We retrospectively reviewed with an incurable lung cancer in two university hospital who were treated platinum doublet or triplet. In this study, was defined as lowest value during days 1-22.We observed 75 patients: 61 men (81%) 14 women (19%), median age of 69 years. The number that elapsed first day chemotherapy ANC 12 longer than...
An 80-year-old woman was referred to our hospital due a persistent productive cough. Acid-fast staining and commercial Mycobacterium tuberculosis identification kit with TRC (TRC kit) were positive. However, false-positive result on the suspected because not detected in sputum culture. Finally, shinjukuense an analysis of rpoB hsp65 gene sequences. As diagnostic criteria proposed by American Thoracic Society met, diagnosis lung disease made. Following treatment isoniazid, rifampicin...
The Chronic Obstructive Pulmonary Disease (COPD) Assessment Test (CAT) is a quality-of-life (QOL) questionnaire that proved to correlate with St. George's Respiratory Questionnaire. Correlations between CAT scores and other COPD parameters have not been thoroughly evaluated in Japanese outpatients.Cross-sectional study of 85 outpatients at community-based hospital.We observed 70 men 15 women, whose average age was 72.0 ± 9.0 years. Mean forced expiratory volume 1 s (FEV1) (% predicted) 45.8...
Abstract: A 27‐year‐old man was admitted to hospital for investigation of haemoptysis. He a serving member the Japan Self‐Defense Forces. CXR showed absence right hilum, and hemithorax smaller than contralateral hemithorax. Pulmonary arteriography demonstrated complete pulmonary artery. Right heart catheterisation did not show any concomitant cardiovascular malformations, patient diagnosed as having isolated Bronchial arteriograms enlargement proliferation small branches bronchial...
The recent H1N1 influenza pandemic involved several cases of pneumonia. Although pneumonia may have occurred more frequently in fatal cases, the clinical characteristics Japan remain unclear. We conducted a retrospective cohort study adult patients with pneumonia, for which questionnaires were sent to respiratory physicians working 2,491 hospitals across Japan. Questionnaires returned by 994 (39.9%), providing data on 346 cases. case-fatality ratio was 8.2% (27 cases). Pure viral observed 94...