A5051562294- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Pleural and Pulmonary Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Head and Neck Cancer Studies
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Meningioma and schwannoma management
- Effects of Radiation Exposure
- Sarcoidosis and Beryllium Toxicity Research
- Myasthenia Gravis and Thymoma
- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Pituitary Gland Disorders and Treatments
- Blood disorders and treatments
- Vascular Malformations and Hemangiomas
- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Ovarian cancer diagnosis and treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Peptidase Inhibition and Analysis
Gunma Chuo Hospital
2015-2024
Kyoto Prefectural University of Medicine
2021
Hokkaido University
2021
Tokyo Metropolitan Hiroo Hospital
2005-2013
Nippon Medical School
1995-2012
Osaka Rosai Hospital
2004-2006
Osaka Police Hospital
2006
Kansai Rosai Hospital
2006
Osaka University
2004
Chiba Hokusou Hospital
1999
The incidence of Pneumocystis jirovecii pneumonia (PCP) in patients with predisposing immunodeficiencies other than AIDS is growing. Knowing the different characteristics and outcomes PCP according to HIV status would help physicians manage treat PCP.The medical charts all a proven first episode PCP, diagnosed between 1997 2007 were retrospectively reviewed, clinical laboratory data abstracted.Of 35 18 HIV-positive 17 HIV-negative immunosuppressive conditions. significantly older patients....
The aim of this study was to investigate significant clinical, tumour-related and dosimetric factors among patients with grade 0-1, 2 3 radiation pneumonitis (RP) after stereotactic body radiotherapy (SBRT) for lung tumours.Patients (n=128) a total 133 tumours treated SBRT 50 Gy in 5 fractions were analysed. RP graded according the Common Terminology Criteria Adverse Events v.3.0. Significant identified by univariate multivariate analyses. Threshold dose-volume histograms (DVHs) constructed...
Key Clinical Message Even in the absence of other symptoms or pulmonary manifestations suggesting Sjögren's syndrome (SS), it is necessary to include SS differential diagnosis diffuse cystic lung disease (CLD). Abstract A case that presented initially with CLD reported. This considered rare because cysts were observed early stage few symptoms, only without lesions on imaging, cyst formation was histologically be alveolar loss, and airway not imaging suspected based function testing. The...
<h3>BACKGROUND</h3> Erythromycin has been reported to have an inhibitory effect on chronic inflammatory airway disease and infiltration of neutrophils into the airway. Bleomycin (BLM) often induces interstitial lung fibrosis following acute injury. A study was undertaken investigate effects erythromycin (EM) experimental bleomycin-induced injury in rats. <h3>METHODS</h3> Bleomycin-induced assessed by light microscopic examination, measurement neutrophil elastase activity interleukin 8 (IL-8)...
We evaluated toxicity and outcomes for patients with peripheral lung tumors treated stereotactic body radiation therapy (SBRT) in a dose-escalation dose-convergence study. A total of 15 were enrolled. SBRT was performed 60 Gy 5 fractions (fr.) prescribed to the 60% isodose line maximum dose, which 100 fr., covering planning target volume (PTV) surface (60 Gy/5 fr. − (60%-isodose)) using dynamic conformal multiple arc (DCMAT). The primary endpoint pneumonitis (RP) ≥ Grade 2 within 6 months....
Histiocytes of Langerhans cell type are recovered from the bronchoalveolar lavage fluid (BALF) patients with interstitial lung diseases in a nonspecific manner. cells (LCs) can be identified through immunostaining for S-100, CD1a, and, more specifically, langerin. To evaluate diagnostic value BALF pulmonary histiocytosis (PLCH), we performed retrospective clinicopathological study 5 biopsy-confirmed PLCH or Hand-Schüller-Christian disease involving lung. As control study, examined 23 various...
To evaluate the outcomes and feasibility of stereotactic body radiotherapy (SBRT) for cT3 cT4N0M0 non-small cell lung cancer (NSCLC), 25 patients with localized primary NSCLC diagnosed as or cT4N0M0, given SBRT between May 2005 July 2013, were analyzed. All had inoperable tumors. The major reasons tumors being unresectable insufficient respiratory function curative resection, advanced age (>80 years old) technically due to invasion into critical organs. median patient was 79 (range; 60-86)....
Radiation pneumonitis is a critical pulmonary toxicity after irradiation of the lung. Macrolides including clarithromycin (CAM) are antibiotics. They also have immunomodulatory properties and used to treat respiratory inflammatory diseases. has similar pathology them. Adverse reactions macrolides few self-limited. We thus administered CAM patients with high-risk factors for radiation pneumonitis, retrospectively investigated whether mitigated following stereotactic body radiotherapy...
A major cause of death in patients undergoing long-term domiciliary oxygen therapy (LTOT) is lung cancer progression. In our institution, we actively perform stereotactic body radiotherapy (SBRT) on with early-stage non-small-cell LTOT. this study, retrospectively analyzed the treatment efficacy and safety SBRT for T1-3N0M0 who had been prescribed LTOT chronic obstructive pulmonary disease (COPD). total 24 were studied. Their median age was 74 years (range, 63-87 years). The duration from...
Pneumocystis jiroveci pneumonia (PCP) is a potentially fatal complication in interstitial patients receiving glucocorticoid therapy. Prophylaxis of PCP during therapy an important issue the treatment pneumonia.We evaluated prophylactic effect sulfamethoxasole-trimethoprim (TMP-SMX) glucocorticoids.We retrospectively analyzed 74 who received therapy.Seven developed PCP. At time diagnosis PCP, mean duration was 71 days and daily dose prednisolone 37 mg. Among 7 patients, circulating CD4+...
The histological type of intraluminal fibrosis is an important prognostic factor for interstitial pneumonia. We therefore examined whether transbronchial lung biopsy (TBLB) specimens are useful predicting the clinical course and prognosis patients with pneumonia associated polymyositis dermatomyositis (PM/DM), particular attention to different types fibrosis.Twenty-five cases PM/DM were classified according pattern as assessed by TBLB, response treatment compared. Interstitial was evaluated...
Background.The value of bronchoalveolar lavage (BAL) still remains controversial, prompting a need for further improvement.The purpose this study was to develop and evaluate sequential analysis cell content in fractional BAL (FBAL) from the airways alveolar sacs with incorporation cellular morphologic features.Methods.Initially, 30 ml saline infused into subsegmental lobe lung recovered fluid assigned as FBAL-I being mainly originated whole airways.The second third lavages (FBAL-II FBAL-III)...