A5102718945- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Virtual Reality Applications and Impacts
- Advanced Optical Imaging Technologies
- Advanced X-ray and CT Imaging
- Gastrointestinal disorders and treatments
- Particle accelerators and beam dynamics
- Diabetes Treatment and Management
- Peptidase Inhibition and Analysis
- Superconducting Materials and Applications
- Visual perception and processing mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Physics of Superconductivity and Magnetism
- Gallbladder and Bile Duct Disorders
- Prostate Cancer Diagnosis and Treatment
- Computer Graphics and Visualization Techniques
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Polyomavirus and related diseases
- Complement system in diseases
- Metastasis and carcinoma case studies
- Digital Filter Design and Implementation
Kawasaki Medical School
2025
Gunma Chuo Hospital
2021-2024
Nakamura Memorial Hospital
2023
Tenri Hospital
2022
University of California, Berkeley
2022
National Institute of Technology, Kagawa College
2022
Ritsumeikan University
2019-2021
Meijo University
2020
Kyoto University
2006-2018
Tohoku University
2018
Nerve conduction studies (NCS) are the standard method for diagnosing diabetic polyneuropathy. Because a clear association between handgrip strength and neuropathy can serve as screening tool, present study evaluated NCS diabetes-related complications. A total of 436 patients with type 2 diabetes (T2D) who were admitted to our hospital April 1, 2018 March 31, 2023, using Baba's classification (BDC) included. The participants grouped by sex grip tertile assess correlations prevalence...
Growth arrest-specific gene (Gas) 6 is a γ-carboxyglutamic acid domain-containing protein, which shares 43% amino identity with protein S. Gas6 has been shown to enhance cancer cell proliferation in vitro . On the other hand, recent studies have demonstrated that inhibits toll-like receptor-mediated immune reactions. Immune reactions are known affect intestinal tumorigenesis. In this study, we investigated how contributes tumorigenesis intestine. Administration of recombinant weakly, but...
The aims of this study were to assess the incidence pancreatic cancer and contributing factors for diagnosis tumors in patients with acute pancreatitis gain insight into how should be followed up.Using electronic medical database Shizuoka General Hospital, 177 admitted past 6 years evaluated retrospectively cancer.Twelve (6.8%) newly diagnosed cancer. During first hospitalization, 5 (41.7%) a detected mass underwent surgical treatment: final tumor stages IA, IIA, IIB 1, 2, 2 patients,...
Chemical synthesis of natural products is typically inspired by the structure and function a target molecule. When both factors are interest, such as in case taxane diterpenoids, can serve platform for synthetic strategy development enable new biological exploration. Guided this paradigm, we present here unified enantiospecific approach to diverse cores from feedstock monoterpenoid (S)-carvone. Key success our was use skeletal remodeling which began with divergent reorganization convergent...
Nonalcoholic steatohepatitis (NASH) is an inflammatory form of nonalcoholic fatty liver disease that progresses to cirrhosis. It still unknown how only limited patients with develop NASH. Tumor necrosis factor (TNF)-α one the key molecules in initiating vicious circle inflammations. Nardilysin (N-arginine dibasic convertase; Nrd1), a zinc metalloendopeptidase M16 family, enhances ectodomain shedding TNF-α, resulting activation responses. In this study, we aimed examine role Nrd1 development...
Deep learning-based virtual patient-specific quality assurance (QA) is a novel technique that enables patient QA without measurement. However, this method could be improved by further evaluating the optimal data to used as input. Therefore, deep model uses multileaf collimator (MLC) information per control point and dose distribution in patient's CT inputs was developed.Overall, 96 volumetric-modulated arc therapy plans generated for prostate cancer treatment were used. We developed (Model...
Abstract This study aims to evaluate the dosimetric accuracy of a deep learning (DL)-based deliverable volumetric arc radiation therapy (VMAT) plan generated using DL-based automated planning assistant system (AIVOT, prototype version) for patients with prostate cancer. The VMAT data (cliDose) 68 cancer treated treatment (70–74 Gy/28–37 fr) at our hospital were used (n = 55 training and n 13 testing). First, HD-U-net-based 3D dose prediction model implemented in AIVOT was customized data....
Chronic inflammation contributes to a wide variety of human disorders. In the stomach, longstanding gastritis often results in structural alterations gastric mucosa, including metaplastic changes and cancers. Therefore, it is important elucidate factors that are involved inflammation. Nardilysin (N-arginine dibasic convertase; Nrdc) metalloendopeptidase M16 family promotes ectodomain shedding precursor forms various growth cytokines by enhancing protease activities disintegrin...
Colon cancer is a complex disease affected by combination of genetic and epigenetic factors. Here we demonstrate that nardilysin (N-arginine dibasic convertase; NRDC), metalloendopeptidase the M16 family, regulates intestinal tumorigenesis via its nuclear functions. NRDC highly expressed in human colorectal cancers. Deletion Nrdc gene ApcMin mice crucially suppressed tumor development. In mice, epithelial cell-specific deletion recapitulated suppression observed Nrdc-null mice. Moreover,...
Objective Nardilysin (NRDC), a zinc peptidase, exhibits multiple localisation-dependent functions including as an enhancer of ectodomain shedding in the extracellular space and transcriptional coregulator nucleus. In this study, we investigated its functional role exocrine pancreatic development, homeostasis formation ductal adenocarcinoma (PDA). Design We analysed Ptf1a-Cre; Nrdc flox/flox mice to investigate impact deletion. Pancreatic acinar cells were isolated from infected with...
症例1は66歳女性.左葉外側区に65 mmの高輝度腫瘤を認めた.ダイナミックCT早期相で淡い高吸収を示し,内部及び辺縁に拡張した血管と考えられる強い線状高吸収を認め,それに連続して左肝静脈が描出された.症例2は33歳女性.S6に35 mmの高輝度腫瘤を認めた.ダイナミックCT早期相で著明な高吸収を呈し,腫瘤と連続した線状高吸収として副肝静脈が描出された.症例3は59歳女性.S2に27 mmの低輝度腫瘤を認めた.ダイナミックCT早期相で淡い高吸収を示し,内部及び辺縁部に拡張した血管と思われる線状高吸収を認め,それに連続して左肝静脈が描出された.症例4は72歳男性.S1に24 mmの内部低輝度領域を伴う高輝度腫瘤を認めた.ダイナミックCT早期相でリング状に造影され,CTHAで腫瘤は強い高吸収を示した.辺縁に腫瘤と連続して下大静脈へ連続する線状高吸収が描出され,副肝静脈と考えられた.4症例とも生検にて肝血管筋脂肪腫(HAML)と診断し外来経過観察中である.流出静脈である肝静脈の早期描出はHAMLの診断に有用である.
It is often challenging to discriminate between intrahepatic cholangiocarcinoma (ICC) and metastatic liver tumors, especially when the hepatic tumor small of a mass-forming type.We report 69-year-old woman presented at our hospital with solid in head pancreas that was previously discovered during medical checkup.The patient diagnosed synchronous pancreatic cancer ICC.The underwent clinical, histological, immunohistological, KRAS mutational analysis.Computed tomography revealed poorly...
In mixed reality using video see-through displays, various optical effects can be simulated for representing a transparent object. However, consumer-available OST-HMDs not reproduce some of their correctly because its mechanism. There has been little discussion concerning to what extent such objects represented realistically. this demonstration, we will show how effective each combination existing methods is.
The feasibility of marker-less stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC) has not yet been established, and, thus, was examined in the present study.We retrospectively investigated patients who received SBRT locally untreated HCC tumors between July 2005 and December 2018. Radiotherapy planning CT performed under fixation with vacuum cushions abdominal compression. clinical target volume (CTV) equivalent to gross tumor (GTV). internal (ITV) margin CTV determined...
A 57-year-old male patient with unresectable pancreatic head cancer was treated chemotherapy, 5 courses of gemcitabine plus nab paclitaxel therapy, and 9 monotherapy. After 12 months treatment, he admitted to our hospital headache dyspnea. He diagnosed gemcitabine-induced thrombotic microangiopathy (TMA) due acute kidney dysfunction, hemolytic anemia, thrombocytopenia. Gemcitabine discontinued, symptoms were improved without using hemodialysis plasma exchange. his renal function recovered,...
We represent virtual transparent objects on OST-HMDs, considering the defocus by accommodation and binocular disparity vergence. In augmented reality with conventional stereoscopic displays, it is difficult to reproduce between images, surface, reflection, refraction, of a object different depths. The reason why that focal always fixed display screen, furthermore, reflection refraction images do not exist in real-time, as they require ray-tracing method for each eye. this study, we...
PURPOSE Clear evidence indicating whether surgery or stereotactic body radiation therapy (SBRT) is best for non–small-cell lung cancer (NSCLC) lacking. SBRT has many advantages. We used artificial neural networks (NNs) to predict treatment outcomes patients with NSCLC receiving SBRT, aiming aid in decision making. PATIENTS AND METHODS Among consecutive between 2005 and 2019 our institution, we retrospectively identified those Tis–T4N0M0 NSCLC. constructed two NNs prediction of overall...