A5043498048- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Catalytic Cross-Coupling Reactions
- Marine Sponges and Natural Products
- Pharmacological Effects of Natural Compounds
- Radical Photochemical Reactions
- Plant biochemistry and biosynthesis
- Plant-based Medicinal Research
- Bioactive Natural Diterpenoids Research
- Cancer Treatment and Pharmacology
- Catalytic Alkyne Reactions
University of California, Berkeley
2017-2022
ConspectusThe preparation of complex molecules (e.g., biologically active secondary metabolites) remains an important pursuit in chemical synthesis. By virtue their sophisticated architectures, natural products inspire total synthesis campaigns that can lead to completely new ways building molecules. In the twentieth century, one such paradigm which emerged was use naturally occurring "chiral pool terpenes" as starting materials for These inexpensive and abundant provide easily accessed...
Chemical synthesis of natural products is typically inspired by the structure and function a target molecule. When both factors are interest, such as in case taxane diterpenoids, can serve platform for synthetic strategy development enable new biological exploration. Guided this paradigm, we present here unified enantiospecific approach to diverse cores from feedstock monoterpenoid (S)-carvone. Key success our was use skeletal remodeling which began with divergent reorganization convergent...
Abstract Eine übergangsmetallvermittelte Spaltung von C‐C‐Einfachbindungen kann eine völlig neue Retrosynthesestrategie in der Naturstoffsynthese ermöglichen. Da C‐C‐Bindungsspaltung das Kohlenstoffgerüst einer Verbindung stets ändert und unter Übergangsmetallkatalyse erzeugte metallorganische oder radikalische Intermediat für den Aufbau größerer Komplexität geeignet ist, eröffnen sich durch diese C‐C‐Bindungsspaltungen Möglichkeiten zum drastischen schnellen Umbau Gerüstsystemen. Die...
The synthesis of diverse N-fused heterocycles, including the pyrido[1,2-a]indole scaffold, using an efficient pyrone remodeling strategy is described. core was demonstrated to be a versatile scaffold that can site-selectively functionalized. utility this novel annulation showcased in concise formal three fascaplysin congeners.
A synthetic strategy to access the fused 6-7-6 tricyclic core of hetisine-type C