A5055040001- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Endometrial and Cervical Cancer Treatments
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- IgG4-Related and Inflammatory Diseases
- Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Sympathectomy and Hyperhidrosis Treatments
- Testicular diseases and treatments
- Neonatal and Maternal Infections
- Colorectal and Anal Carcinomas
Kagoshima University
2014-2024
Jichi Medical University
2021
Sendai Shakai Hoken Hospital
2020
Izumi City General Hospital
2020
Aichi Cancer Center
2017-2019
Kagoshima Medical Center
2017
Kagoshima City Hospital
2017
Kagoshima University Hospital
2017
Kitasato University
2000
Nippon Medical School
1967
Abstract Background and Aim Endoscopic ultrasound‐guided hepaticogastrostomy (EUS‐HGS) is performed as an alternative to the percutaneous or surgical approach. Despite high success rates, adverse events rate high. Recently, we used 6‐mm fully covered self‐expandable metal stents prevent allow easy re‐intervention. The purposes were evaluate safety, feasibility, clinical efficacy. Methods A prospective study confirm safety of EUS‐HGS was carried out in six patients, followed by a trial...
There is a paucity of data on the diagnostic efficacy liquid-based cytology (LBC) for pancreatic samples obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Using propensity score matching, we retrospectively analyzed additional value LBC compared to conventional Papanicolaou smear (CPS) solid lesions EUS-FNA.This cohort study included 126 matched patients who underwent initial EUS-FNA between January 2009 and August 2014. CPS was used until May 2012 (63 patients)....
This study evaluated the feasibility and clinical utility of liquid-based cytology (LBC) specimens via endoscopic ultrasound–guided fine-needle biopsy (EUS-FNB) for next-generation sequencing (NGS) pancreatic cancer (PC). We prospectively performance DNA extraction NGS using EUS-FNB samples obtained from PC. Thirty-three consecutive patients with PC who underwent at our hospital were enrolled. 96.8% patients. When stratified a variant allele frequency (VAF) > 10% tumor burden, success...
Abstract Background As liquid‐based cytology (LBC) specimens preserve high‐quality DNA, clinical sequencing of LBC using next‐generation (NGS) is becoming a common strategy. This study aimed to evaluate the feasibility NGS‐based custom‐made panels for evaluating MUC promoter methylation in specimens. Methods Thirty‐one patients with pancreatic cancer were enrolled study. Cancer tissue samples obtained endoscopic ultrasound‐guided fine‐needle aspiration/biopsy (EUS‐FNA/FNB). LBC,...
Abstract Background and study aims To investigate bleeding risk thromboembolic in patients receiving antithrombotic therapy who underwent endoscopic ultrasound-guided fine-needls aspiration (EUS-FNA). Patients methods A single-center retrospective of 908 consecutive undergoing EUS-FNA for pancreatic non-pancreatic lesions between March 2013 2017 was performed. Antithrombotic management classified into three groups: continuous, discontinuation, heparin replacement. Results total 114 (12.6 %)...
Helicobacter pylori (Hp) eradication is recommended for improving the quality of life (QOL) patients with epigastric symptoms, especially reflux and dyspepsia. However, no reports have investigated improvement QOL after Hp irrespective symptoms. The aim this study was to investigate in evaluate factors associated an improved Hp. This prospective cohort performed at 15 referral institutions from September 2013 December 2014. patients' symptoms were evaluated before using 8-item Short-Form...
Septal thickness (ST) can predict a malignant branch-duct (BD) and mixed-type intraductal papillary mucinous neoplasm (IPMN) of the pancreas, but its cut-off value has not been established. The aim present study was to determine optimal ST malignancy using endoscopic ultrasound (EUS).We retrospectively identified 200 patients with IPMN, including 132 BD- mixed-IPMN, who underwent surgical resection between 1989 2017. defined as septum or lesion wall maximum diameter in mixed-IPMN....
ABSTRACT Background and Objectives: In transpapillary biliary drainage, metal stents (MSs) exhibit a lower incidence of obstruction than plastic (PSs). However, few studies have compared recurrent (RBO) when MSs PSs are used in EUS-guided hepaticogastrostomy (EUS-HGS) choledochoduodenostomy (EUS-CDS). We retrospectively evaluated the RBO for both each procedure. Patients Methods: Between November 2012 December 2020, 85 53 patients who underwent EUS-HGS EUS-CDS unresectable malignant...
A 20-year old man was diagnosed with fibrolamellar hepatocellular carcinoma (FLHCC) multiple lung metastases, and chemotherapy FOLFOX administered. Contrast enhanced CT after 3 cycles of showed no disease progression. We therefore performed surgical resection radiofrequency ablation the liver lesions obtaining patient's informed consent. The metastases tested positive for DNAJB1-PRKACA. treatment FLHCC extrahepatic metastasis has not been established; however, in a few cases, good long-term...
Gallbladder neuroendocrine carcinoma (NEC) is a rare gallbladder tumor. The current report case of patient preoperatively diagnosed with NEC using somatostatin receptor scintigraphy (SRS). A 63‑year‑old man was admitted to our hospital by family doctor after abdominal ultrasonography revealed thickened walls the neck his gallbladder. At Kagoshima University Hospital, CT and MRI abdomen endoscopic confirmed thickening However, it did not resemble typical cancer or tumor, such as tumor...
<b><i>Background and Aims:</i></b> Hexanoyl (Hx:C6) group-modified alkaline-treated gelatin porous film (HAG) is a newly developed degradable hydrogel characterized by strong adhesiveness high affinity for vascular endothelial growth factor (VEGF). The aim of this study was to clarify the effect HAG sheets on healing process post-endoscopic submucosal dissection (ESD) porcine gastric artificial ulcers. <b><i>Methods:</i></b> (1) To evaluate...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unknown etiology. Recently, mucosal healing has emerged as an important therapeutic endpoint in UC. Linked color imaging (LCI) novel endoscopic system that enhances the differences of gastrointestinal mucosa. Our previous study emphasized redness and yellowness lesion using LCI observation, which was useful for evaluation histological activity In this study, we aimed to evaluate correlation between observation clinical...
Background . Bilateral biliary drainage decreases the risk of cholangitis, but bilateral endoscopic metallic stenting is technically challenging. Aim We retrospectively evaluated factors associated with successful self-expanding metal stent (SEMS) placement using partial stent-in-stent (PSIS) method for malignant hilar obstruction and also assessed safety efficacy this technique. Methods From April 2010 to February 2016, 47 consecutive patients (mean age, <mml:math...
An 87-year-old bedridden woman developed intestinal obstruction caused by an enterolith or bezoar. Since the patient refused surgery, we administered 1,000 mL/day of cola via ileus tube to dissolve stone. Occlusion small intestine disappeared on day 6. The excreted stones contained calcium phosphate, which is typical enteroliths. We later confirmed that retrieved could be dissolved in (Coca-Cola®, pH 1.9) as well 0.10 and 0.010 mol/L hydrochloric acid (pH 1.0 2.0, respectively) food-grade...
本論文は,転移を有する膵癌でgemcitabine(GEM)化学療法後に治癒切除ができた2例の報告である.症例1は69歳男性.CTで膵体部腫瘍を指摘され,EUS-FNAでadenocarcinomaの診断となった.開腹手術に臨んだが,腹膜播種結節を認め試験開腹術となった.GEM単剤化学療法を開始し,18か月間増大なく播種結節は同定し得なかった.再度開腹手術に臨み腹膜播種は認めず,膵体尾部切除術を施行した.症例2は73歳女性.CTで膵体部腫瘍と肝S4に低吸収域を認め,EUS-FNAでadenocarcinomaであり,膵癌肝転移の診断となった.GEM単剤化学療法を開始し,原発巣,肝転移巣は不明瞭化し,9か月間増悪なく,腹腔動脈合併膵体尾部切除術,肝部分切除術を施行した.切除不能膵癌に対するconversion surgeryの適応を検討する上で貴重な症例であり,文献的考察を加え報告する.
BACKGROUND: New immunotherapy using immune checkpoint inhibitors plays a critical role in cancer treatment. Immune inhibitor-related colitis (irAE-colitis) occurs approximately 1–20% of patients treated with inhibitors. There are limited data on the outcomes optimal treatment irAE-colitis. The aim this report was to clarify for irAE-colitis our facilities. METHODS: Of 676 who received at hospital and related facilities, nine developed were included. We defined effectiveness as follows:...
Disconnected pancreatic duct syndrome (DPDS) is characterized by extraductal leakage of juice and destruction tissue surrounding the pancreas [1]. Many DPDS cases need surgical treatment [2]. Transpapillary stenting endoscopic ultrasound (EUS)-guided transmural drainage PD walled-off necrosis (WON) are also reported to be effective for [2] [3] [4]. The EUS-guided rendezvous technique (EUS-RV) was shown as a salvage procedure connect disruption directly when procedures treat proved ineffective.