A5103008672- Pancreatic and Hepatic Oncology Research
- Genetic Associations and Epidemiology
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Diabetes Management and Research
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Carbon Nanotubes in Composites
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Peroxisome Proliferator-Activated Receptors
- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- Nutrition, Genetics, and Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gastrointestinal disorders and treatments
- RNA Research and Splicing
- Gastrointestinal Tumor Research and Treatment
- Renal and Vascular Pathologies
- Vascular Tumors and Angiosarcomas
- Liver Disease Diagnosis and Treatment
Aichi Cancer Center
2010-2025
Jichi Medical University Saitama Medical Center
2017-2024
The University of Tokyo
2008-2024
Jichi Medical University
2017-2024
Tokyo Medical University Hospital
2018
Diabetes Australia
2016
Icahn School of Medicine at Mount Sinai
2015-2016
Tokyo Medical University
2015-2016
Shinshu University
2009-2014
Ōtani University
2010-2012
Abstract Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these by analysis variants HumanExome BeadChip in 60,564 non-diabetic individuals 16,491 T2D cases 81,877 controls. We identify a novel association low-frequency nonsynonymous SNV GLP1R (A316T; rs10305492; MAF=1.4%) with lower FG ( β =−0.09±0.01 mmol l −1 , P =3.4 × 10 −12 ), risk (OR[95%CI]=0.86[0.76–0.96], =0.010), early secretion (β =−0.07±0.035 pmol =0.048),...
The allele frequencies for a Pro12-->Ala substitution in peroxisome proliferator-activated receptor-gamma differ among ethnic groups, and its relationship with diabetes associated diseases is controversial. prevalence of this polymorphism effects on clinical characteristics have now been evaluated large number Japanese individuals type 2 (n = 2,201) normal control subjects 1,212) recruited by 10 institutions located seven different cities Japan. frequency the Ala12 variant was significantly...
We have purified S-100 protein from bovine brain using Ca2+-dependent affinity chromatography on
Multi-walled carbon nanotubes (MWCNTs) promote calcification during hydroxyapatite (HA) formation by osteoblasts. Primary cultured osteoblasts are incubated with MWCNTs or black. After culture for 3 weeks, the degree of is very high in 50 μg mL−1 MWCNT group. Transmission electron microscopy shows needle-like crystals around MWCNTs, and diffraction patterns reveal that peak almost coincides known HA.
The addition of carbon nanotubes (CNTs) remarkably improves the mechanical characteristics base materials. CNT/alumina ceramic composites are expected to be highly functional biomaterials useful in a variety medical fields. Biocompatibility and bone tissue compatibility were studied for application as biomaterials.Inflammation reactions response composite mild those alumina alone subcutaneous implantation study. In testing, showed good connected directly new bone. An vitro cell attachment...
To confirm the association between male pattern baldness and coronary heart disease (CHD).Meta-analysis of observational studies.Medline Cochrane Library were searched for articles published up to November 2012 using keywords that included both 'baldness' 'coronary disease' reference lists those studies identified also searched.Observational reported risk estimates CHD related baldness. Two observers independently assessed eligibility, extracted data possibility bias.The adjusted relative...
Abstract Background and Aim The aim of this study is to elucidate the natural history pancreatic cystic lesions (PCLs), including branch duct‐type intraductal papillary mucinous neoplasm (BD‐IPMN), via midterm follow‐up analysis a multicenter prospective observational (NSPINAL study). Methods From July 2011 October 2016, 881 patients with PCLs were enrolled in NSPINAL study, 664 > 12 months follow up analyzed. Every patient was asymptomatic, endoscopic ultrasound performed at initial...
Obesity prevalence has increased in Japan recent years. Given the strong association of obesity with poor glycemic control, and risk type 2 diabetes (T2D) central obesity, this study describes current trends relationships between glycated hemoglobin (HbA1c), body mass index (BMI), waist circumference Japanese people T2D. This was a retrospective, cross-sectional T2D who had at least one recorded HbA1c BMI (or circumference) value Medical Data Center Claims database. Five annual cohorts...
Objective: Although pancreatic ductal adenocarcinoma (PDAC) is still a devastating disease, the survival rate for surgically removed PDACs has significantly improved in recent years. Early detection essential managing PDAC. Summary Background Data: The presence of KRAS mutations PDAC leads to initial genetic abnormality and offers significant timeframe identifying resectable PDACs. A minimally invasive highly specific screening test necessary prevent need follow-up tests. Methods: Between...
Malignant lesions of the pancreatic head can cause obstructive jaundice requiring biliary drainage. However, effect post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and metal stents on surgical resection remains controversial. This study aimed to investigate efficacy primary endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) performed prior pancreatoduodenectomy, excluding patients with duct cancer. We retrospectively analyzed consecutive who underwent...