A5071173334- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Lung Cancer Treatments and Mutations
- Heart Rate Variability and Autonomic Control
- Lung Cancer Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Receptor Mechanisms and Signaling
- Diet, Metabolism, and Disease
- Digestive system and related health
- Diabetes Management and Research
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- Estrogen and related hormone effects
- Diabetic Foot Ulcer Assessment and Management
- Muscle metabolism and nutrition
- Diabetes and associated disorders
- Radiomics and Machine Learning in Medical Imaging
- Muscle Physiology and Disorders
- Hematological disorders and diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
University of California, Los Angeles
2025
Saiseikai Ibaraki Hospital
2012-2023
Denso (Japan)
2019
Graduate School for the Creation of New Photonics Industries
2019
Kawasaki Medical School
2011-2015
Okayama Saiseikai General Hospital
2008-2015
Kawasaki Medical School Hospital
2012-2013
Kyoto University
1999-2008
Kindai University
2001-2006
Mie University
2006
The allele frequencies for a Pro12-->Ala substitution in peroxisome proliferator-activated receptor-gamma differ among ethnic groups, and its relationship with diabetes associated diseases is controversial. prevalence of this polymorphism effects on clinical characteristics have now been evaluated large number Japanese individuals type 2 (n = 2,201) normal control subjects 1,212) recruited by 10 institutions located seven different cities Japan. frequency the Ala12 variant was significantly...
The Trp 64 Arg mutation in the β3-adrenergic receptor (β3AR) gene was investigated 350 Japanese subjects. This not associated with non-insulin-dependent diabetes mellitus (NIDDM). In 191 subjects without NIDDM, body mass index (BMI) significantly higher homozygous for this than those normal allele (24.7±1.4 vs 22.1±0.2 kg/m2, p=0.009). Moreover, frequency of mutant obese (BMI>26.4) that non-obese (BMI<22) (0.37 0.15, presence also accompanied by fasting (p=0.000) and 2 hrs (p=0.018) serum...
The small intestine plays an important role in the digestion and absorption of many nutrients. To investigate contribution carbohydrate to diabetes mellitus, we examined morphological changes intestine, expression sucrase-isomaltase, which is one intestinal disaccharidases, diabetic model rat, that streptozotocin-induced (STZ) rat (insulin-deficient model), Otsuka Long-Evans Tokushima Fatty (OLETF) rats Goto-Kakizaki (GK) (type 2 models). Intestinal hyperplasia was observed STZ, OLETF, GK...
Tocotrienols, members of the vitamin E family, have been shown to possess anti-inflammatory properties and display activity against a variety chronic diseases, such as cancer, cardiovascular neurological diseases. However, whether tocotrienols contribute prevention inflammatory responses in adipose tissue remains be elucidated. In this study, we examined effects γ-tocotrienol, most common tocotrienol isomer, on tumor necrosis factor-α (TNF-α)-induced by measuring expression adipokines,...
OBJECTIVESRecently, the prognosis of patients with non-small-cell lung cancer (NSCLC) has improved, thanks to standardization adjuvant chemotherapy and introduction molecular-targeted drugs, notably epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors other new anti-cancer agents. However, survival characteristics recurrent NSCLC after curative resection are not well understood.
Introduction Several cytotoxic anticancer drugs inhibit DNA replication and/or mitosis, while EGFR tyrosine kinase inhibitors inactivate signalling in cancer cell. Both types of improve the overall survival patients with non-small-cell lung (NSCLC), although tumors often become refractory to this treatment. Despite several mechanisms by which resistant having been described effect these compounds on anti-tumor immunity remains largely unknown. Methods This study examines drug Gemcitabine and...
Summary 1. Fibre type distributions of the slow soleus and fast plantaris muscles were investigated in 5‐, 9‐ 20‐week‐old male Goto‐Kakizaki (GK) rats, as an animal model non‐obese diabetes, compared with those age‐matched non‐diabetic Wistar rats. 2. Bodyweight both muscle weights lower GK rats than regardless age. In addition, relative per bodyweight 3. muscle, a higher percentage I fibres IIA observed 5‐ 9‐week‐old there no 4. differences fibre distribution 5‐week‐old However, IIB 5....
OBJECTIVE—Isolated postchallenge hyperglycemia (IPH), defined as fasting plasma glucose (FPG) level &lt;7.0 mmol/l and 2-h (PG) ≥11.1 mmol/l, is a subtype of early-stage diabetes. This study evaluates the metabolic profiles insulin secretion sensitivity in IPH to clarify factors responsible for development this form type 2 RESEARCH DESIGN AND METHODS—We conducted cross-sectional analysis 231 Japanese men aged 20–70 years. The subjects were classified into following three groups, based on...
Gastric inhibitory polypeptide (GIP) potently stimulates insulin secretion from pancreatic islets in the presence of glucose as an incretin. Because insulinotropic effect GIP is reduced NIDDM, it should be clarified whether defects receptor gene contribute to impaired NIDDM. Using genomic DNA samples Japanese NIDDM and non-NIDDM subjects, we have investigated entire coding region by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP). We identified two missense...
Previous studies revealed that rat islets express the GLUT2-liver facilitative glucose transporter isoform, a carrier with low affinity for but high capacity transport. These indicated presence of second in islets; however, they did not indicate to which five known transporters it corresponded. In this study, we isolated RNA from Langerhans and confirmed GLUT2 mRNA. addition, present dataindicating isoform expressed is GLUT1-erythrocyte isoform.The effect culturing 5.5, 8.3, or 11.1 mM on...
Several polymorphisms of genes involved in autonomic nervous system (ANS) function have been reported to affect metabolic regulation. We investigated the association an alpha(2B)-adrenergic receptor (alpha(2B)AR) three-amino acid deletion polymorphism with ANS activity young healthy subjects by means electrocardiogram R-R interval power spectral analysis. Three hundred eighty-one Japanese males (mean +/- SE, 20.6 0.1 yr) were studied. One sixty-eight (44.1%) homozygotes Long allele...
Objective. To investigate the characteristics of isolated impaired glucose tolerance (IGT) and fasting (IFG), we analyzed factors responsible for elevation 2-hour postchallenge plasma (2 h PG) (FPG) levels. Methods. We investigated relationship between 2 PG FPG levels who underwent 75 g OGTT in 5620 Japanese subjects at initial examination medical check-up. compared clinical IGT IFG relationships with characteristics, indices insulin secretory capacity, sensitivity. Results. In a comparison...
The effects of hyperbaric exposure with high oxygen concentration on glucose and insulin levels skeletal muscle-fiber properties were investigated in type 2 diabetic Goto-Kakizaki rats. Five-week-old rats exposed to a environment (1.25 atmospheric pressure) (36%) for 6 h daily. Glucose including fiber-type distribution, cross-sectional area, oxidative enzyme activity the soleus muscle examined after 4 weeks. growth-related increase level was inhibited by exposure, also showed lower compared...
SUMMARY Dipeptidyl peptidase IV (DPP‐IV) is a new drug target in the treatment of Type 2 diabetes. enzyme activity significantly altered diabetic patients with hyperglycaemia, but underlying molecular mechanisms remain unclear. The first aim present study was to clarify whether glucose regulates DPP‐IV activity. To address this, gene expression and were measured Caco2 cells cultured presence low (2.5 mmol/L) or high (16.7 concentrations glucose. We observed that inhibited second investigate...