A5069392282- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Pleural and Pulmonary Diseases
- Immunotherapy and Immune Responses
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- CAR-T cell therapy research
- Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Research Studies
- Inflammatory mediators and NSAID effects
- T-cell and B-cell Immunology
- Pneumothorax, Barotrauma, Emphysema
- Peptidase Inhibition and Analysis
- Inflammatory Biomarkers in Disease Prognosis
- Tracheal and airway disorders
- Head and Neck Cancer Studies
- Congenital Diaphragmatic Hernia Studies
- Radiomics and Machine Learning in Medical Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Estrogen and related hormone effects
- Immune cells in cancer
National Sanyo Hospital
2018-2024
Okayama University
2022-2023
Kawasaki Medical School
2012-2021
Kawasaki Medical School Hospital
2012-2017
Karolinska Institutet
2010-2015
Hiroshima University Hospital
2008-2013
Hiroshima University
2005-2012
Gene Therapy Laboratory
2012
Shikoku Cancer Center
2002-2007
Nippon Kayaku (Japan)
2007
The immunological status, consisting of "inflammation status" and "nutritional condition," is important for the survival patients with various cancers, including non-small cell lung cancer (NSCLC). neutrophil/lymphocyte ratio (NLR) reflects inflammation prognostic nutritional index (PNI) condition. In present study, correlation between NLR PNI as well consistency magnitude impact were investigated. We conducted a retrospective review data from 334 who had undergone curative resection NSCLC....
Abstract Overexpression of the receptor tyrosine kinases HER2 and HER3 is associated with a poor prognosis in several types cancer. Presently, HER2- as well HER3-targeted therapies are clinical practice or evaluated within trials, including treatment mAbs mediating growth inhibition and/or activation Ab-induced innate adaptive cellular immunity. A better understanding how HER2/HER3 signaling tumors influences immune mechanisms therefore warranted. In this study, we demonstrate that regulates...
OBJECTIVESRecently, the prognosis of patients with non-small-cell lung cancer (NSCLC) has improved, thanks to standardization adjuvant chemotherapy and introduction molecular-targeted drugs, notably epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors other new anti-cancer agents. However, survival characteristics recurrent NSCLC after curative resection are not well understood.
Pneumatosis intestinalis (PI) is defined as the presence of gas in bowel wall and a relatively rare finding. PI has been associated with various pathological conditions medications. Although several chemotherapeutic agents molecular targeted therapy are reported to be PI, there have few reports describing association between anti-epidermal growth factor receptor agent gefitinib, tyrosine kinase inhibitor (TKI), PI. The present report describes case secondary gefitinib therapy.An 80-year-old...
The HER2 oncogene is frequently over-expressed in human cancers and a promising target for immune therapy. Previous studies have shown that over-expression of mouse or rat leads to markedly reduced levels major histocompatibility complex (MHC) class I molecules the antigen processing presentation machinery (APM), thus resulting phenotype promoting tumor escape from system. Our study focuses on analyzing effect MHC sensitivity tumor-antigen specific cytotoxic T lymphocytes (CTLs) HLA-A2.1(+)...
Introduction Several cytotoxic anticancer drugs inhibit DNA replication and/or mitosis, while EGFR tyrosine kinase inhibitors inactivate signalling in cancer cell. Both types of improve the overall survival patients with non-small-cell lung (NSCLC), although tumors often become refractory to this treatment. Despite several mechanisms by which resistant having been described effect these compounds on anti-tumor immunity remains largely unknown. Methods This study examines drug Gemcitabine and...
The maximal standardized uptake value (SUVmax) of pulmonary lesions on dual-time-point (DTP) fluorodeoxyglucose positron emission tomography (FDG-PET) has been shown to be useful for differentiation between malignant and non-malignant lesions, also intrathoracic nodal staging non-small cell lung cancer (NSCLC). However, a few NSCLC have found show decreased FDG delayed images, the significance this finding remains unknown.We conducted retrospective review data 284 patients with who underwent...
We performed an analysis to clarify differences in clinicopathological and molecular features of lung invasive mucinous adenocarcinoma (IMA) based on computed tomography (CT) findings their impact prognosis.On the basis CT findings, we divided IMA into three subtypes: solid, bubbling, pneumonic. then investigated characteristics, prognosis, expressions well-identified biomarkers, including cyclooxygenase-2 (Cox-2), excision repair cross-complementation group 1 (ERCC1), ribonucleotide...
There is no clear evidence in the literature regarding regulation of programmed cell death-ligand 1 (PD-L1) expression by cyclo-oxygenase-2 (COX2). In this study, whether PD-L1 was regulated COX2 activity examined vitro.Resected lung cancer specimens were analyzed for and immunohistochemical analysis. Next, co-localization double-fluorescence staining. Lastly, effect inhibition on using lines.PD-L1 significantly correlated with resected specimens. The majority cells that expressed also...
Vascular endothelial growth factor (VEGF) plays an important role in tumor angiogenesis. Several studies have reported that genomic VEGF polymorphisms may influence synthesis. To evaluate the of single nucleotide (SNPs), we examined expression several angiogenesis-related proteins [VEGF, hypoxia-inducible factor-1α (HIF-1α) and delta-like ligand 4 (Dll4)] spread microvessels resected non-small cell lung cancer (NSCLC). Blood tissue from 83 patients with NSCLC were for -460T/C (rs833061)...
Background: Adjuvant chemotherapy after the complete resection of non-small-cell lung cancer (NSCLC) is now standard care. To improve survival, it important to identify risk factors for continuation adjuvant chemotherapy. In this study, we analyzed compliance and magnitude prognostic impact nutritional index (PNI) before Methods: We conducted a retrospective review data from 106 patients who had received The consisted an oral tegafur agent (OT) or platinum-based (PB). correlations between...
Abstract We assessed the prognostic value of five complex inflammatory and nutritional parameters, namely neutrophil-to-lymphocyte ratio (NLR), index (PNI), C-reactive protein-to-NLR (C/NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR) using data from patients with malignant pleural mesothelioma (MPM) undergoing extrapleural pneumonectomy (EPP). Moreover, correlation between these parameters programmed cell death protein 1 ligand-1 (PD-L1) expression in tumor microenvironment...
Several biomarkers have been reported as predictors of survival and recurrence in non-small cell lung cancer. Recently, several groups demonstrated that the immune microenvironment primary tumors is a prognostic factor. These "immunological biomarkers" tumor are useful prognosis well promising targets for novel therapeutic approaches. Especially, tumor-infiltrating Treg cells powerful immunological biomarker, possible mechanisms involved induction expression Cox-2, IL-12Rβ2 or lack IL7R on...
EGFR/HER2 are frequently expressed in MPM tissues, however, no studies have shown the clinical benefit of using EGFR/HER2-targeting drugs patients with malignant pleural mesothelioma (MPM). It was reported that tyrosine kinase inhibitor (TKI) lapatinib enhanced trastuzumab-mediated antibody-dependent cellular cytotoxicity (ADCC) HER2-positive breast cancer, suggesting this combination is a promising strategy for treatment. The aim present study to explore possibility TKI combined trastuzumab...
Adjuvant chemotherapy after the resection of stage IB-IIIA non-small cell lung cancer (NSCLC) is now standard care based on large-scale phase III trials and a meta-analysis. However, has plateaued in terms its efficacy, search for treatment prediction biomarkers imperative further identification treatable subgroups. Therefore, we investigated significance cyclooxygenase-2 (Cox-2) expression applicability Cox-2 inhibitor patients who had received adjuvant chemotherapy. We conducted...
Programmed cell death-1 ligand 1 (PD-L1), tumor-infiltrating CD8-positive T lymphocytes (CD8-positive TILs), and cyclooxygenase-2 (Cox-2) have been used as prognostic tools in patients with lung adenocarcinoma. We conducted a retrospective review of data from 170 who had undergone pulmonary resection an initial treatment for clinical T1-2 N0 then investigated the expressions three biomarkers using immunohistochemical analyses compared expression levels clinicopathological characteristics...
The maximal standardized uptake value (SUVmax) on fluorodeoxyglucose-positron emission tomography (FDG-PET) for primary tumors is correlated with clinicopathological and prognostic factors in patients non-small cell lung cancer. However, previous investigations have discussed the role of SUVmax without distinguishing among histological subtypes Herein, we investigated correlations FDG-PET, or factors, expression tumor angiogenic biomarkers according to subtypes. We conducted a retrospective...