A5102733414- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Folate and B Vitamins Research
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Diabetes Management and Education
- Nutrition and Health in Aging
- Consumer Attitudes and Food Labeling
- Fatty Acid Research and Health
- Alcohol Consumption and Health Effects
- Pain Mechanisms and Treatments
- Body Composition Measurement Techniques
- Vitamin D Research Studies
- Iron Metabolism and Disorders
- Heart Rate Variability and Autonomic Control
- COVID-19 Clinical Research Studies
- Obesity and Health Practices
- Diet, Metabolism, and Disease
- Ion Channels and Receptors
- Diabetes Treatment and Management
National Center for Global Health and Medicine
2015-2024
Center for Global Health
2011-2022
Ehime University
2019-2021
Tottori University
2018-2021
Yamaguchi University
2021
Shujitsu University
2016
National Institute of Public Health
2005-2011
Saitama International Medical Center
2007-2010
Okayama University
2009
National Institute of Health Sciences
2004-2006
Abstract Objective : To describe the 25‐year changes in BMI (measured kilograms per meters squared) and prevalence of obesity Japanese children with special reference to urban‐rural differences. Research Methods Procedures We used data sets from cross‐sectional annual nationwide surveys (National Nutrition Survey, Japan) conducted 1976 2000 comprising 29, 052 boys 27, 552 girls between 6 14 years age. carried out trend analyses on sex age groups residential areas according size municipality...
Abstract Amino acids have emerged as novel biomarkers for predicting type 2 diabetes (T2D), but the epidemiologic data linking circulating amino acid profiles with T2D are sparse in Asian populations. We conducted a nested case-control study within cohort of 4,754 nondiabetic Japanese employees who attended comprehensive health checkup 2008–2009 and agreed to provide blood samples. During 5-year follow-up, incident cases were ascertained based on plasma glucose, glycated hemoglobin,...
Although abdominal obesity and related metabolic abnormalities are hypothesized to promote colorectal carcinogenesis, direct confirmation of this effect is required. Here, we examined the relation early-stage neoplasia visceral fat area markers insulin resistance.Subjects were participants in a comprehensive health screening conducted at Hitachi Health Care Center, Ibaraki, Japan. During 3-year period (2004-2007), total 108 patients with neoplasia, including 22 early cancer, identified among...
Adiponectin has anti-inflammatory and insulin-sensitizing properties. Prospective studies have consistently shown a lower risk of type 2 diabetes among those with higher circulating adiponectin levels.We examined prospectively the association between serum levels Japanese workers, taking visceral fat mass into account.Subjects were 4591 employees who attended comprehensive health screening in 2008; had biochemical data including adiponectin; free at baseline; received 2011. Multiple logistic...
OBJECTIVE We examined the relationships of visceral fat area (VFA), subcutaneous area, and waist circumference, determined using computed tomography (CT), BMI with metabolic risk factors in a large Japanese population. RESEARCH DESIGN AND METHODS Study subjects comprised 6,292 men women who participated Hitachi Health received CT examinations 2007 2008. RESULTS Regarding clustering factors, odds ratios (ORs) for VFA quintiles were 1.0 (ref.), 2.4, 3.4, 5.0, 9.7 1.5, 2.6, 4.6, 10.0 (P...
The effect of smoking cessation on the risk diabetes has been reported previously. However, it is unknown whether association influenced by weight gain and other potential factors.The Japan Public Health Center-Based Prospective Study established in 1990 for Cohort I 1993 II provided data, 25,875 men 33,959 women were analyzed. response rate to baseline questionnaire was 80.9%, 68.4% respondents participated both 5- 10-year follow-up surveys. Smoking noted during initial five years...
The relationship between different types of meat intake and the risk type 2 diabetes remains unclear. We prospectively examined association total meat, red unprocessed processed poultry incidence diabetes. Subjects were 27 425 men 36 424 women aged 45–75 years who participated in second survey Japan Public Health Center-based Prospective Study, had no history diabetes, cancer, stroke, IHD, chronic liver disease or kidney disease. Meat was estimated using a validated 147-item FFQ. OR...
While iron plays an important role in many cellular functions, excess storage induces DNA damage by generating hydroxyl radicals and thus promotes carcinogenesis. However, it remains unclear whether body levels that are commonly observed a general population related to oxidative damage. We examined the association between serum ferritin concentrations of urinary 8‐hydroxydeoxyguanosine (8‐OHdG), biomarker systemic repair, 528 Japanese men women aged 21–67 years. Men had much higher than...
Background: Several lines of evidence indicate an important role for vitamin D in the prevention a range diseases. Blood levels show clear seasonal variation; however, data on determinants status each season are limited. We investigated association between lifestyle and serum concentration by Japanese workers.Methods: Subjects were 312 men 217 women aged 21 to 67 years who worked municipal offices Northern Kyushu, Japan participated periodic checkup July or November. Multiple linear...
The prevalence of metabolic syndrome (MS) has been remarkably increasing worldwide. However, few studies have examined the effect lifestyle intervention among subjects with MS. We investigated a six-month modification program on MS and its associated biomarkers Japanese men MS.Subjects were randomly assigned to either (n=53) or control (n=54) group. Subjects in group received focused exercise diet behavior from trained occupational health nurse at baseline one three months. was assessed by...
<h3>Background</h3> Few studies have examined the impact of weight change in different periods lifetime on type 2 diabetes risk, and association loss with is unclear. We prospectively investigated since age 20 y that during middle-to-late adulthood incidence diabetes. <h3>Methods</h3> Subjects were 52 014 men women aged 45–75 who participated Japan Public Health Center-Based Prospective Study had no history ORs self-reported physician-diagnosed for between baseline survey (mean 50.6 y) 5...
Weight gain after smoking cessation may deteriorate metabolic risk profiles, including that for syndrome. How profiles change according to the duration of and whether visceral fat area (VFA) or subcutaneous (SFA) contributes these changes remains uncertain. The subjects comprised 5,697 Japanese men who underwent an abdominal computed-tomography examination during a health check-up. Using never smokers as reference group, odds ratios having syndrome its components, defined using National...
Higher iron storage has been linked to an increased risk of type 2 diabetes, but little is known about the mediator this association. Here, we prospectively investigated association between circulating ferritin, a marker storage, and incidence diabetes among Japanese individuals.The participants were 4,754 employees who attended comprehensive health check-up in 2008-2009 donated blood for study. During 5 years follow up, was identified based on plasma glucose, glycated hemoglobin...
Data on the long-term risks of non-AIDS defining cancers (NADCs) are limited, especially in Asians. The incidence NADCs may correlate with epidemiological trend or oncogenic infection each country, and thus target would be different between Western Asian countries. We aimed to elucidate its predictive factors HIV-infected patients.