A5037233428- Anesthesia and Pain Management
- Nausea and vomiting management
- Anesthesia and Sedative Agents
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Cardiac Ischemia and Reperfusion
- Respiratory Support and Mechanisms
- Enhanced Recovery After Surgery
- Pain Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Nasolacrimal Duct Obstruction Treatments
- Sleep and related disorders
- Sirtuins and Resveratrol in Medicine
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Hemodynamic Monitoring and Therapy
- Thermal Regulation in Medicine
- Mesenchymal stem cell research
- Ginseng Biological Effects and Applications
- Mitochondrial Function and Pathology
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Beijing Hospital
2011-2024
Peking Union Medical College Hospital
2024
Cleveland Clinic Lerner College of Medicine
2016-2017
Affiliated Hospital of Qingdao University
2010-2011
Qingdao University
2010-2011
Abstract Transnasal humidified rapid insufflation ventilator exchange (THRIVE) may be effective in delaying hypoxia, but the efficacy of THRIVE for oxygenation elderly patients under general anaesthesia has not been assessed. This study assessed whether prolonged apnoea time after induction. was a single centre, two-group, randomized controlled trial. 60 (65 to 80 years age) with American Society Anesthesiologists (ASA) grades I ~ III who required tracheal intubation or application laryngeal...
Abstract More than 240 million opioid prescriptions are dispensed annually to treat pain in the US. The use of opioids is commonly associated with tolerance (OT) and opioid-induced hyperalgesia (OIH), which limit efficacy compromise safety. dearth effective way prevent or OT OIH a major medical challenge. We hypothesized that mesenchymal stem cells (MSCs) attenuate rats mice based on understanding MSCs possess remarkable anti-inflammatory properties both chronic neuroinflammation spinal...
Background This study investigated whether a novel multi-injection intertransverse process block could provide non-inferior analgesia and recovery quality following major breast cancer surgery compared with the thoracic paravertebral block. Methods Eighty-eight females who underwent mastectomy plus sentinel or axillary lymph node dissection were randomized to receive either block, both performed at T2–6 5 mL of 0.5% ropivacaine per level. The primary outcome was worst resting pain score...
Objectives: The current treatment options for neuropathic pain due to nerve injuries are limited and largely unsatisfactory. Mesenchymal stem cell transplantation (MSC) has shown promise as an emerging therapy pain. However, a number of critical parameters, including the sources cells, routes transplantation, need be elucidated before it can tested clinically. Methods: MSCs were isolated from rat bone marrow (rBM-MSCs) adipose tissue (rAD-MSCs) characterized by flow cytometry functional...
Although interscalene nerve block is the standard for shoulder analgesia, risk of hemidiaphragmatic paralysis restricts its use in patients with compromised pulmonary function. We hypothesized that a novel subparaneural upper trunk would provide noninferior postoperative analgesia but superior diaphragmatic sparing effect compared to block.This randomized controlled trial comprised 96 who underwent arthroscopic surgery under either (5 mL 0.5% ropivacaine) or (15 ropivacaine), followed by...
Background A brachial plexus block plays an important role in providing perioperative analgesia for shoulder surgery; however, the inherent risk of phrenic nerve and resulting hemidiaphragmatic paralysis may limit its use patients with compromised pulmonary function. This study aimed to evaluate safety, efficacy, maximum tolerated volume, optimal biologic volume 0.5% ropivacaine used a single-injection retroclavicular arthroscopic surgery. Methods In this seamless single-arm exploratory...
Morphine tolerance is one of the most common complications in patients with chronic pain. Many morphine have poor efficacy treatment primary pain, and are accompanied by side effects. Previous studies found that many mechanisms involved tolerance, but few researches could fully explain no effective for has been found. One expression profiling data set was downloaded from Gene Expression Omnibus (GEO) database. The probes would be transformed into homologous gene symbol means platform's...
Following the gastrectomy, reduction in pulmonary function is partly attributed to postoperative pain. Subcostal quadratus lumborum block (QLB) has recently emerged as a promising component multimodal analgesia. We aimed assess impact of intermittent boluses subcostal QLB on recovery and analgesic efficacy after gastrectomy. Sixty patients scheduled for gastrectomy were randomly assigned either control group (multimodal analgesia) or intervention (intermittent plus analgesia). Two primary...
BACKGROUND Clinical comparisons between intertransverse process block (ITPB) and erector spinae plane (ESPB) are lacking. OBJECTIVE This study aimed to compare their blocking profile clinical efficacy in breast cancer surgery. DESIGN Randomised, blinded, active-controlled superiority trial. SETTING A tertiary hospital China from 20 February 31 July 2023. PATIENTS Sixty-eight females undergoing unilateral INTERVENTION Patients were randomised receive either ITPB performed at T2–6 (5 ml of...
In recent years, with the popularity of laryngeal mask airway (LMA) for management clinical anesthesia, influence LMA on position and blood flow internal jugular vein (IJV) has attracted an increasing amount attention.To investigate effect placement different types (Supreme LMA, Guardian I-gel LMA) right IJV.This was a prospective randomized controlled trial. A total 102 patients aged 18-75 years who were scheduled to undergo laparoscopic abdominal surgery general anesthesia randomly...
Objective To validate the performance of model for predicting risk intraoperative hypothermia.Methods This observational prospective study enrolled adult patients who were American Society Anesthesiologists Ⅰ-Ⅲ and underwent elective surgery with general anesthesia in Peking Union Medical College Hospital,Beijing Hospital,and Xuanwu Hospital Capital University from October 2019 to August 2021.The prediction hypothermia was used calculate predictors score each patient.The body temperature...
Objective To investigate the side effect of absorbable hemostatic gauze in dacryocystorhinostomy.Methods 15 patients (15 eyes) with chronic dacryocystitis had undergone dacryocystorhinostomy,in which 4 cases(4 used randomly operation.Results cases gauze,satisfactory hemostasis was obtained operation,but lacrima tractus obstructed again 9-14 days after operation.The lacrimal passages other were unobstructed.Conclusion The using dacryocystorhinostomy may induce secondary nasolacrimal duct...
Objective To investigate the effect of different time administration parecoxib sodium on postoperative analgesic efficacy in patients undergoing thoracic surgery. Methods This was a prospective,randomized, double-blind, placebo-controlled study. Sixty ASA Ⅰ orⅡ aged 17-83 yr pulmonary lobectomy were randomly allocated to one 3 groups (n=20 each):A, B and C groups. Group A received normal saline 2 ml at 30 min before skin incision end operation. iv 40 mg All patient-controlled intravenous...
Objective To determine the target effect-site concentration ( EC50 and EC95 ) of sufentanil blunting responses to double-lumen endotracheal intubation when combined dexmedetomidine propofol by target-controlled infusion (TCI).Methods Thirty ASA Ⅰ or Ⅱ patients aged 40-64 yr with body mass index ＜ 30 kg/m2 undergoing thoracic surgery under general anesthesia.Dexmedetomidine 0.6 μtg/kg was infused iv over 10 min followed continuous at 0.3 μg· kg- 1 · h- until before end operation.The initial...
Objective To investigate the effect of nicorandil pretreatment on myocardial mitochondria in a rabbit model ischemia-reperfusion (I/R). Methods Tirty-two healthy male New Zealand white rabbits weighing 2.0-2.5 kg aged 4 months were randomly allocated into groups ( n = 8 each): Ⅰ group sham operation (group S); Ⅱ I/R; Ⅲ N) and Ⅳ + 5 hydroxydecanoic acid N 5-HD). Myocardial I/R was induced by 30 min occlusion left circumflex coronary artery followed 120 reperfusion. In 5-HD bolus 100 μg/kg...
Objective To compare the efficacy of laryngeal mask airway-Advance (ALMA) and airway-Supreme (S-LMA) in patients undergoing laparoscopic cholecystectomy.Methods Two hundred forty ASA Ⅰ or Ⅱ patients,aged 18-64 yr,weighing 50-70 kg,undergoing cholecystectomy,were randomly divided into2 groups (n=120 each):group S-LMA (group S) group A-LMA A).LMA was inserted after induction general anesthesia with propofol 2.0-2.5 mg/kg,sufentanil 0.2 μg/kg rocuronium 0.6 mg/kg.After LMA placed,the rim...
Abstract Background and Objective Postoperative gastrointestinal dysfunction (POGD) is a leading cause of delayed hospital stay after abdominal surgery. Goal-directed fluid therapy (GDFT) may improve (GI) function, but the evidence for beneficial effects GDFT recovery GI function remains controversial. The aim this study was to evaluate effect on postoperative length in patients undergoing major oncologic Methods In randomized, partly blinded, controlled trial, adult scheduled elective...