A5100406505- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Metabolomics and Mass Spectrometry Studies
- Protein Structure and Dynamics
- Cell death mechanisms and regulation
- Ferroptosis and cancer prognosis
- Tea Polyphenols and Effects
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Protein Interaction Studies and Fluorescence Analysis
- Peroxisome Proliferator-Activated Receptors
- Nutrition and Health in Aging
- 14-3-3 protein interactions
- Genetics and Neurodevelopmental Disorders
- Cancer Cells and Metastasis
- Calpain Protease Function and Regulation
- Histone Deacetylase Inhibitors Research
- Pancreatic function and diabetes
- Lung Cancer Research Studies
- Ginseng Biological Effects and Applications
- Immunotherapy and Immune Responses
- Per- and polyfluoroalkyl substances research
Nanjing Drum Tower Hospital
2025
Nanjing University
2022-2025
Chengdu Medical College
2024
Guangxi University
2024
China Medical University
2021
Beijing Normal University
2019
Anhui Medical University
2019
81th Hospital of PLA
2017
Peking University
2000-2016
Peking University Third Hospital
2016
The plasmacytoma variant translocation 1 gene (PVT1) is a large non-coding locus at adjacent of c-Myc, and long RNA PVT1 now recognized as cancerous co-amplified with c-Myc in various cancers. But the expression functional role colorectal cancer are still unelucidated. In addition, all reported RNAs so far discovered either cells or tissues, but no research about detection extracellular vesicles has been yet. present study, we firstly investigated specimens its correlation other related...
Although personalized neoantigen cancer vaccines have emerged as a promising strategy for treatment, challenges remain to develop immune-stimulatory carriers which allow simultaneous transport of adjuvants and lymph nodes (LNs). With inherent immunogenicity, genetic plasticity, efficiency large-scale production, M13 phages represent an attractive platform vaccine delivery natural bionanomaterials. Here, we report the discovery anti-CD40 designed ankyrin repeat protein (DARPin) propose...
Val-->Ala mutations within the effective transmembrane segment of a model single-spanning membrane protein, 50-residue major coat (gene VIII) protein bacteriophage M13, are shown to have sequence-dependent impacts on stabilization membrane-embedded helical dimeric structures. Randomized mutagenesis performed hydrophobic 21-39 (YIGYAWAMV-VVIVGATIGI) produced library viable mutants which included those in each four valine residues was replaced by an alanine residue. Significant variations...
MicroRNA-106b (miR-106b) was recently identified as an oncogene participating in cancer progression. Transforming growth factor β1(TGF-β1) is indispensable cytokine regulating the local microenvironment, thereby promoting cervical However, roles of miR-106b carcinoma progression and TGF-β1-involvement tumorigenesis remain unknown. The expression human specimens detected by real-time PCR analysis situ hybridization assay. effect on cell migration analyzed scratch transwell assays. TGF-β1 used...
Dysregulated endocrine hormones (EHs) contribute to tumorigenesis, but how EHs affect the tumor immune microenvironment (TIM) and immunotherapy of non-small cell lung cancer (NSCLC) is still unclear. Here, endogenous ouabain (EO), an adrenergic hormone, elevated in patients with NSCLC closely related pathological stage, metastasis, survival. EO promotes suppression TIM vivo by modulating expression checkpoint proteins, which programmed death protein ligand 1 (PD-L1) plays a major role....
Abstract Background Multiple Sclerosis (MS) is a potentially devastating autoimmune neurological disorder, which characteristically induces demyelination of white matter in the brain and spinal cord. Methods In this study, three characteristics central nervous system (CNS) immune microenvironment occurring during MS onset were explored; cell proportion alteration, differential gene expression profile, related pathways. The raw data two independent datasets obtained from ArrayExpress...
To analyze the interaction between PML protein and TAB1 using bioinformatic approaches experimentally verify results.
The ubiquitin-proteasome system degrades most cellular proteins in eukaryotes. UCH37, also known as UCH-L5, is a deubiquitinase binding to Rpn13, receptor for ubiquitinated substrates the 26 S proteasome. But, it remains unclear how UCH37 influences proteasomal degradation of substrates. Because deletion embryonically lethal mice, this study aims investigate role by constructing UCH37-deficient cell lines using CRISPR/Cas9 technology. Our results demonstrated that decreased levels implying...
A more accurate prognosis is important for clinical treatment of lung adenocarcinoma. However, due to the limitation sample and technical bias, most prognostic signatures lacked reproducibility, few were applied practice. In addition, understanding molecular driving mechanism indispensable developing promising therapies Here, we built an unbiased significance model perform integrative analysis, including differentially expressed genes data with adenocarcinoma patients from TCGA....
Abstract Although transmembrane (TM) segments of integral membrane proteins are putatively alpha-helical in conformation, beta-sheet promoters (Val, Ile, Thr) often account for approximately 40% TM residue composition. We examining the conformational role(s) these residues, using as a model system major coat protein filamentous bacteriophage M13. This 50-residue protein, which is located at Escherichia coli host during phage reproduction, contains prototypic 19-residue hydrophobic midregion...
Ethnopharmacological relevance: Hyperlipidemia as a major health issue has attracted much public attention. As geographical indication product of China, Liupao tea (LPT) is typical representative traditional Chinese dark that shown good potential in regulating glucose and lipid metabolism. LPT important medicinal value hyperlipidemia prevention. However, the active ingredients metabolic mechanisms by which alleviates remain unclear.Aim study: This study aimed to systematically investigate...
Objective To investigate the use of parenteral nutrition in hospitalized patients and to examine process care receiving (PN) hospital, light EuropeanNutrition Daystudy, preliminarily explore possible main risk factors for complications. Methods We recruited 314 adult (≥18 years) requiring PN on a predetermined day(November 25, 2013)in 6 hospitals Beijing investigated their disease status, risk, venous infusion related complications using European Nutrition Day survey...
<p>Supplementary References. References for Supplementary Tables and Figures</p>
<div>Abstract<p>Cables1 is a candidate tumor suppressor that negatively regulates cell growth by inhibiting cyclin-dependent kinases. Cables1 expression lost frequently in human cancer but little known about its regulation. Here, we report levels are controlled phosphorylation and 14-3-3–dependent mechanism. Mutagenic analyses identified two residues, T44 T150, specifically critical for 14-3-3 binding serve as substrates the survival kinase Akt, which directly to recruits...