A5100760275- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Cardiac Ischemia and Reperfusion
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Immune cells in cancer
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Iron Metabolism and Disorders
- Lipoproteins and Cardiovascular Health
- Circular RNAs in diseases
- Alcohol Consumption and Health Effects
- Atrial Fibrillation Management and Outcomes
- Parathyroid Disorders and Treatments
- S100 Proteins and Annexins
- Cholesterol and Lipid Metabolism
- Immune Cell Function and Interaction
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Biomarkers in Disease Mechanisms
- Alcoholism and Thiamine Deficiency
Southern Medical University
2021-2024
Tianjin Chest Hospital
2015-2024
Tianjin University
2024
Nanfang Hospital
2021-2024
Tianjin Medical University
2015-2021
Xinxiang Medical University
2015
Oxidized low-density lipoprotein (ox-LDL)-induced endothelial cell dysfunction is a significant event in the progression of atherosclerosis. Even Myricetin (Myr) has been exhibited strong antioxidant potency, effect on atherosclerosis still elusive. HUVECs were subjected to ox-LDL, before which cells preconditioned with Myr. Cell Counting Kit-8 assay, flow cytometry, quantitative real-time polymerase chain reaction and Western blot carried out assess impacts ox-LDL Myr HUVECs. The expression...
MicroRNAs (miRNAs) are important gene regulators in both biological and pathological processes, including myocardial ischemia/reperfusion (I/R) injury. This study investigated the effect of miR-613 on I/R-induced cardiomyocyte apoptosis its molecular mechanism action. Hypoxia/reoxygenation (H/R) significantly increased release lactate dehydrogenase (LDH), levels malondialdehyde (MDA), apoptosis, but these effects were attenuated by an mimic. Programmed cell death 10 (PDCD10) was identified...
Vascular calcification is related to many diseases. Iron has a certain relationship with endothelial cells and vascular calcification. The purpose of this study was assess the effect iron overload on cell mechanisms through experiments.Human umbilical vein were treated different concentrations FeSO4 (50, 100, 150, 200 µM), deferoxamine (DFO) ferrostatin. Alkaline phosphatase activity, malondialdehyde (MDA) level, reactive oxygen species (ROS) lipid superoxidation after treatment assessed....
Atherosclerosis is a lipid-driven chronic inflammatory disease in which lipid-laden macrophage foam cells lead to inflamed lesions arteries. Previous studies have proven that sulfotransferase 2B1b (SULT2B1b) has several roles the regulation of lipid metabolism and response. However, little known about functions SULT2B1b ox-LDL-induced inflammation macrophages. In this study, after treatment with either ox-LDL alone or combined transfection siRNAs targeting SULT2B1b, IL-6, TNF-α, NF-κB, IKKβ...
Atherosclerosis (AS) is the most dangerous factor for human death, which a lipid-driven chronic inflammatory disorder of arteries. Growing evidence has showed that microRNAs play an important role in AS. However, mir-193b-3p atherosclerosis been poorly studied to date. Therefore, we focused on potential miR-193b-3p atherosclerosis. The expressions serum AS patients were detected. We also established oxidized low density lipoprotein (ox-LDL)-induced umbilical vein endothelial cells (HUVECs)...
Postoperative Atrial Fibrillation (POAF) frequently follows Coronary Artery Bypass Grafting (CABG) surgery. This prospective study investigates genes linked to POAF in CABG patients, aiming create a predictive model. Employing differential gene and methylation analyses, the identified four (WARS2, CKAP2, CHI3L1, HSD17B6) associated with POAF. Preoperative plasma samples clinical data were collected from 139 categorized into (+) (43) (-) (96). Real-time quantitative PCR assessed expression,...
The aim of this study was to observe the effect a formulation traditional Chinese medicine extracts known as Xingnaojia (XNJ) on liver function, learning ability and memory rats with chronic alcoholism verify mechanism by which it protects brain liver. A rat model used in study. spatial were tested. then sacrificed their brains hepatic tissues isolated. activity superoxide dismutase (SOD) levels glutamate (Glu), N‑methyl D‑aspartate receptor subtype 2B (NR2B), cyclin‑dependent kinase 5...
Abstract BackgroundOxidized low-density lipoprotein (ox-LDL)-induced an endothelial cell dysfunction is a significant event in the progression of atherosclerosis[1]. Even myricetin (Myr) has been exhibited strong antioxidant potency, effect on atherosclerosis still elusive. MethodsHUVECs were subjected to ox-LDL, before which cells preconditioned with Myr. Cell Counting Kit-8 (CCK-8) assay, flow cytometry, quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot carried...
Abstract Background Triglyceride and glucose index (TYG) triglyceride to high density lipoprotein cholesterol ratio (TG/HDL-c) not only were significant association with hypertension, but also related prehypertension. However, few of these studies have large subjects study the relationship between TyG ,TG/HDL prehypertension in same population. Therefore, We conducted a cross-sectional explore TG/HDL-c, hypertension normoglycemic from China, Tianjin . Methods A total 32,124 adults eligible...