A5100711971- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Plant tissue culture and regeneration
- Pineapple and bromelain studies
- Plant Gene Expression Analysis
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Extracellular vesicles in disease
- Plant-Microbe Interactions and Immunity
- Epigenetics and DNA Methylation
- 2D Materials and Applications
- Biomarkers in Disease Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- Amino Acid Enzymes and Metabolism
- Composting and Vermicomposting Techniques
- Neural dynamics and brain function
- Advanced Drug Delivery Systems
- Acute Kidney Injury Research
- MXene and MAX Phase Materials
- Drug Solubulity and Delivery Systems
- Advanced Neuroimaging Techniques and Applications
- Immune cells in cancer
University of Electronic Science and Technology of China
2025
Fujian Agriculture and Forestry University
2021-2024
Jinan University
2023
Guangxi University
2023
Xinjiang Academy of Agricultural Sciences
2023
Southern Medical University
2014-2022
Nanfang Hospital
2015-2022
Zhujiang Hospital
2022
Fujian University of Traditional Chinese Medicine
2022
Tianjin haihe hospital
2022
Abstract The co-infection of porcine reproductive respiratory syndrome virus (PRRSV) and circovirus type 2 (PCV2) is quite common in clinical settings no effective treatment to the available. In this study, we established alveolar macrophages (PAM) cells model co-infected with PRRSV/PCV2 modification vitro , investigated antiviral activity Matrine on cell further evaluated effect virus-induced TLR3,4/NF-κB/TNF-α pathway. results demonstrated PAM inoculated PRRSV followed by PCV2 h later...
Maladaptive inflammatory and immune responses are responsible for intestinal barrier integrity function dysregulation. Proline/serine-rich coiled-coil protein 1 (PSRC1) critically contributes to the system, but direct data on gut microbiota microbial metabolite trimethylamine N-oxide (TMAO) lacking. Here, we investigated impact of PSRC1 deletion TMAO generation atherosclerosis. We first found that in apoE−/− mice accelerated atherosclerotic plaque formation, then metabolites were detected...
Currently, stem cell transplantations in cardiac repair are limited owing to disadvantages, such as immunological rejection and poor viability. Although direct injection of exosomes can have a curative effect similar that transplantation, high clearance hinders its application clinical practice. Previous reports suggested induction coronary collateralization be desired method adjunctive therapy for someone who had missed the optimal operation time attenuate myocardial ischemia. In this...
<p indent="0mm">Pyroptosis is a regulated inflammatory cell death process that plays an essential role in various diseases. This study investigates the of proline/serine-rich coiled-coil protein 1 (PSRC1) pyroptosis and inflammation macrophages. reports PSRC1 expression decreased pyroptotic macrophages knockout <italic>PSRC1</italic> exacerbates inflammation. overexpression alleviates RNA-seq analysis reveals regulates genes involved extracellular matrix (ECM). Specifically, downregulates...
Hypoxia-induced cardiomyocyte apoptosis contributes significantly to the development of numerous cardiac diseases, such as ischemic heart disease, failure, etc. Promoting cell survival by inhibiting is one available strategies attenuate dysfunction caused loss. Previous studies have been demonstrated that miR-138 and lipocalin-2 (Lcn2) play important roles in survival. We presently determined whether Lcn2 a target gene involved hypoxia-induced apoptosis. Firstly, mimics were transfected into...
Unfavorable environmental cues severely affect crop productivity resulting in significant economic losses to farmers. In plants, multiple regulatory genes, such as the WRKY transcription factor (TF) family, modulate expression of defense genes. However, role pineapple genes is poorly understood. Here, we studied gene, AcWRKY28, by generating AcWRKY28 over-expressing transgenic plants. Overexpression enhanced salt stress resistance lines. Comparative transcriptome analysis and wild-type...
Recently, intercalation emerges as an effective way to manipulate ground-state properties and enrich quantum phase diagrams of layered transition metal dichalcogenides (TMDCs). In this work, we focus on fully Ta-intercalated bilayer $2H\text{\ensuremath{-}}{\mathrm{TaS}}_{2}$ with a stoichiometry ${\mathrm{Ta}}_{3}{\mathrm{S}}_{4}$, which has recently been experimentally synthesized. Based first-principles calculations, computationally show the suppression intrinsic...
Abstract Previously, we reported that heat shock protein (HSP)65 impairs the effects of high-density lipoprotein on macrophages. We also showed immune response activation adversely affects reverse cholesterol transport (RCT). In this study, investigated Src family kinase lymphocyte-specific tyrosine (Lck) and elucidated mechanism underlying HSP65-regulated efflux in T cells. evaluated cell proliferation, Lck expression, inflammatory cytokine production Jurkat cells CD4+ HSP65-mediated...
Atherosclerosis is a lipid-driven chronic inflammatory disease in which lipid-laden macrophage foam cells lead to inflamed lesions arteries. Previous studies have proven that sulfotransferase 2B1b (SULT2B1b) has several roles the regulation of lipid metabolism and response. However, little known about functions SULT2B1b ox-LDL-induced inflammation macrophages. In this study, after treatment with either ox-LDL alone or combined transfection siRNAs targeting SULT2B1b, IL-6, TNF-α, NF-κB, IKKβ...
Pineapple is a globally significant tropical fruit, but its cultivation faces numerous challenges due to abiotic and biotic stresses, affecting quality quantity. WRKY transcription factors are known regulators of stress responses, however, their specific functions in pineapple not fully understood. This study investigates the role AcWRKY31 by overexpressing it Arabidopsis. Transgenic lines were obtained using Agrobacterium-mediated transformation methods treatments. AcWRKY31-OE plants showed...
Abstract The current main treatment for coronary artery disease (CAD) is to reduce low-density lipoprotein cholesterol (LDL-C) by statins, which could decrease the incidence of major adverse cardiovascular events (MACEs) 30%. However, many residual risks still remain. To clarify mechanism involved, we studied patients with acute myocardial infarction (AMI) low LDL-C levels. Lymphocytes were isolated, and it was found that despite no difference in plasma level, lymphocyte content higher AMI...
The aim of the present study was to probe mechanism apoptosis induced by endoplasmic reticulum stress (ERS) in manganese‑induced rats. A total 60 Sprague‑Dawley rats were randomly divided into a Vehicle group, LoMag HiMag and + 4‑phenylbutyrate (PBA) group. Manganese content measured Inductively Coupled Plasma‑Atomic Emission Spectrometry. Pathogenic morphology, cellular structure striatum ER observed hematoxylin eosin staining electron microscopy. TUNEL method used examine neuronal rat...
Purpose: To prepare and characterize buccal transmucosal delivery system of enalapril maleate for overcoming its low bioavailability, hence provide improved therapeutic efficacy patient compliance.Methods: Transmucosal drug systems were formulated as films by solvent casting technique using polyvinylpyrrolidone K90, hydroxypropyl methylcellulose, sodium carboxymethylcellulose (high viscosity). The evaluated film weight, thickness, folding endurance, content uniformity, surface pH, in vitro...